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Metabolic Dysfunction-Associated Steatotic Liver Disease: From Basic Science to Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 102

Special Issue Editor

Special Issue Information

Dear Colleagues,

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become an important healthcare issue. To reduce the potential associated complications, including liver cirrhosis and hepatocellular carcinoma, a rapid response to this issue is of utmost importance. In order to achieve such a goal, significant research efforts in the field of liver studies are necessary. With this in mind, we hereby invite you to contribute novel papers on the different mechanisms involved in the development of liver steatosis and its progression toward inflammation and carcinogenesis. A great addition to this Special Issue would be manuscripts on therapeutic approaches toward MASLD, both in vitro and in vivo. Finally, we also encourage the submission of papers in clinical settings showing the potential benefits of currently approved drugs that might find usage in MASLD treatment.

Dr. Łukasz Bułdak
Guest Editor

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Keywords

  • MASLD
  • liver steatosis
  • steatohepatitis
  • liver cirrhosis
  • hepatocellular carcinoma
  • in vivo
  • in vitro
  • therapy

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Published Papers (1 paper)

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Review

31 pages, 1225 KiB  
Review
Metabolomic Hallmarks of Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease
by Diren Beyoğlu, Yury V. Popov and Jeffrey R. Idle
Int. J. Mol. Sci. 2024, 25(23), 12809; https://doi.org/10.3390/ijms252312809 (registering DOI) - 28 Nov 2024
Abstract
From a detailed review of 90 experimental and clinical metabolomic investigations of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD), we have developed metabolomic hallmarks for both obesity and MASLD. Obesity studies were conducted in mice, rats, and humans, with consensus biomarker groups [...] Read more.
From a detailed review of 90 experimental and clinical metabolomic investigations of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD), we have developed metabolomic hallmarks for both obesity and MASLD. Obesity studies were conducted in mice, rats, and humans, with consensus biomarker groups in plasma/serum being essential and nonessential amino acids, energy metabolites, gut microbiota metabolites, acylcarnitines and lysophosphatidylcholines (LPC), which formed the basis of the six metabolomic hallmarks of obesity. Additionally, mice and rats shared elevated cholesterol, humans and rats shared elevated fatty acids, and humans and mice shared elevated VLDL/LDL, bile acids and phosphatidylcholines (PC). MASLD metabolomic studies had been performed in mice, rats, hamsters, cows, geese, blunt snout breams, zebrafish, and humans, with the biomarker groups in agreement between experimental and clinical investigations being energy metabolites, essential and nonessential amino acids, fatty acids, and bile acids, which lay the foundation of the five metabolomic hallmarks of MASLD. Furthermore, the experimental group had higher LPC/PC and cholesteryl esters, and the clinical group had elevated acylcarnitines, lysophosphatidylethanolamines/phosphatidylethanolamines (LPE/PE), triglycerides/diglycerides, and gut microbiota metabolites. These metabolomic hallmarks aid in the understanding of the metabolic role played by obesity in MASLD development, inform mechanistic studies into underlying disease pathogenesis, and are critical for new metabolite-inspired therapies. Full article
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