Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Antitumor and Anti-infective Agents from Marine Organisms
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Antitumor and Anti-infective Agents from Marine Organisms

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 7793

Special Issue Editors

Dr. Chiara Lauritano

E-Mail Website
Guest Editor
Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via F. Acton 55, 80133 Naples, Italy
Interests: microalgae; drug discovery; gene mining; marine biotechnology; transcriptomics
Special Issues, Collections and Topics in MDPI journals
Dr. Assunta Saide

E-Mail Website
Guest Editor
Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
Interests: marine biotechnology; cellular biology; characterization of natural compounds; compound mechanism of action; cell cycle analysis; cell death; search bioactive molecules from microalgae; anti-cancer; anti-oxidant; anti-inflammatory
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oceans cover nearly 70% of the earth surface and host a huge biodiversity of species. Marine organisms have evolved the capability to survive in very hostile environments (such as extreme temperatures, changes in salinity and pressure, predation and attack by pathogens) which have also favoured the production of molecules that often have no terrestrial counterpart. The demand for new drugs for the treatment and prevention of human diseases has triggered a growing interest in marine sources for the discovery of new molecules. Actually, there are 14 marine drugs on the market and 23 marine derived compounds in clinical trials. Cancer treatment is the most frequent field of application, maybe because these compounds have often defensive roles in the natural environments. Recently, there is a renewed interest in exploring the marine habitat also thanks to the advancement in cultivation technologies and omics analyses (such as transcriptome and genome mining). Marine biotechnology studies have shown that several compounds from marine organisms can have pharmaceutical, nutraceutical and other industrial applications. We would like to encourage the submission in this special issue "Marine Natural Products" to collect recent original research and reviews in the field, highlighting bioactivities of natural products derived from marine organisms and their possible applications.

Importantly, the exact active ingredient of natural origin extract must be reported in the submitted research manuscript, since papers describing the effects of mixed extraction from natural origin are not acceptable.

Dr. Chiara Lauritano
Dr. Assunta Saide
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine organisms
  • antitumor compounds
  • bioactive molecules
  • marine biotechnology
  • drug discovery
  • cancer treatment
  • mechanism of action

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

17 pages, 13328 KiB  
Article
Crassolide Induces G2/M Cell Cycle Arrest, Apoptosis, and Autophagy in Human Lung Cancer Cells via ROS-Mediated ER Stress Pathways
by Kuan-Ming Lai, Jou-Hsuan Wang, Shih-Chao Lin, Ya Wen, Chao-Liang Wu, Jui-Hsin Su, Chien-Chin Chen and Chi-Chien Lin
Int. J. Mol. Sci. 2022, 23(10), 5624; https://doi.org/10.3390/ijms23105624 - 17 May 2022
Cited by 21 | Viewed by 4320
Abstract
Crassolide, a cembranoid diterpene extracted from the soft coral Lobophytum crissum, has been proven to possess antioxidant and immunomodulatory properties. In the present study, we assessed the anticancer effects of crassolide on human H460 non-small-cell lung cancer (NSCLC) cells. We found that [...] Read more.
Crassolide, a cembranoid diterpene extracted from the soft coral Lobophytum crissum, has been proven to possess antioxidant and immunomodulatory properties. In the present study, we assessed the anticancer effects of crassolide on human H460 non-small-cell lung cancer (NSCLC) cells. We found that crassolide exerted cytotoxic effects on H460 cancer cells in vitro, inducing G2/M phase arrest and apoptosis. In addition, in H460 cells exposed to crassolide, the expression of the autophagy-related proteins LC3-II and beclin was increased, while the expression of p62 was decreased. Moreover, inhibiting autophagy with chloroquine (CQ) suppressed the crassolide-induced G2/M arrest and apoptosis of H460 cells. Moreover, we also found that crassolide induced endoplasmic reticulum (ER) stress in lung cancer cells by increasing the expression of ER stress marker proteins and that the crassolide-induced G2/M arrest, apoptosis, and autophagy were markedly attenuated by the ER stress inhibitor 4-phenylbutyric acid (4-PBA). Furthermore, we found that crassolide promoted reactive oxygen species (ROS) production by H460 cells and that the ROS inhibitor N-acetylcysteine (NAC) decreased the crassolide-induced ER stress, G2/M arrest, apoptosis, and autophagy. In conclusion, our findings show that crassolide inhibits NSCLC cell malignant biological behaviors for the first time, suggesting that this effect may be mechanistically achieved by inducing G2/M arrest, apoptosis, and autophagy through ROS accumulation, which activates the ER stress pathway. As a result of our findings, we now have a better understanding of the molecular mechanism underlying the anticancer effect of crassolide, and we believe crassolide might be a candidate for targeted cancer therapy. Full article
(This article belongs to the Special Issue Antitumor and Anti-infective Agents from Marine Organisms)
►▼ Show Figures

Figure 1

Review

Jump to: Research

23 pages, 2022 KiB  
Review
Marine Compounds for Melanoma Treatment and Prevention
by Eleonora Montuori, Anita Capalbo and Chiara Lauritano
Int. J. Mol. Sci. 2022, 23(18), 10284; https://doi.org/10.3390/ijms231810284 - 7 Sep 2022
Cited by 6 | Viewed by 2606
Abstract
Melanoma is considered a multifactorial disease etiologically divided into melanomas related to sun exposure and those that are not, but also based on their mutational signatures, anatomic site, and epidemiology. The incidence of melanoma skin cancer has been increasing over the past decades [...] Read more.
Melanoma is considered a multifactorial disease etiologically divided into melanomas related to sun exposure and those that are not, but also based on their mutational signatures, anatomic site, and epidemiology. The incidence of melanoma skin cancer has been increasing over the past decades with 132,000 cases occurring globally each year. Marine organisms have been shown to be an excellent source of natural compounds with possible bioactivities for human health applications. In this review, we report marine compounds from micro- and macro-organisms with activities in vitro and in vivo against melanoma, including the compound Marizomib, isolated from a marine bacterium, currently in phase III clinical trials for melanoma. When available, we also report active concentrations, cellular targets and mechanisms of action of the mentioned molecules. In addition, compounds used for UV protection and melanoma prevention from marine sources are discussed. This paper gives an overview of promising marine molecules which can be studied more deeply before clinical trials in the near future. Full article
(This article belongs to the Special Issue Antitumor and Anti-infective Agents from Marine Organisms)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop