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Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 995

Special Issue Editors


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Guest Editor
Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15 A, 15-276 Białystok, Poland
Interests: carcinogenesis; cancer diagnostics; cancer markers; minerals; alcohol dehydrogenase isoenzymes; aldehyde dehydrogenase; nutrition; food safety
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. 2nd Clinical Department of General, Gastroenterological and Oncological Surgery, Medical University of Bialystok Clinical Hospital, M. Skłodowskiej-Curie 24 A, 15-276 Białystok, Poland
2. Department of Surgical Nursing, Medical University of Bialystok, Szpitalna 37, 15-274 Białystok, Poland
Interests: gastrointestinal tract cancers; oncology; cancer diagnostics; general surgery; gastroenterological surgery; apoptosis

Special Issue Information

Dear Colleagues,

Gastrointestinal tract cancers pose a significant public health challenge globally, and their incidence is constantly increasing. We suffer from colon cancer more often, but the number of liver cancer cases is also increasing. At the same time, three cancers of the gastrointestinal tract, pancreatic cancer, gallbladder cancer, and liver and intrahepatic bile duct cancer, were placed on the list of the ten most lethal cancers by the American Society of Oncology (ACS).

The molecular aspects of gastrointestinal cancers are the subject of intense research, which may lead to generating a better understanding of the genetic changes and molecular pathways associated with gastrointestinal cancers, facilitating the development of targeted therapies and personalized therapeutic approaches, contributing to improving patient outcomes, greater diagnostic accuracy, and a better overall survival rate. Continued research and innovation in these areas provide hope for making further progress in the prevention, diagnosis, and development of new therapeutic strategies for gastrointestinal cancers.

In this Special Issue, we present original research and literature reviews discussing various aspects of the pathology, diagnosis, and therapy of gastrointestinal cancer.

Dr. Karolina Orywal
Dr. Mariusz Gryko
Guest Editors

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Keywords

  • gastrointestinal cancer
  • esophageal cancer
  • gastric (stomach) cancer
  • colorectal cancer
  • liver cancer
  • pancreatic cancer
  • gallbladder and biliary tract cancer
  • genetic alterations
  • molecular subtyping
  • tumor microenvironment
  • innovative therapies
  • targeted therapies
  • tumor biomarkers

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Published Papers (1 paper)

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Review

11 pages, 585 KiB  
Review
Potential Utility of A Proliferation-Inducing Ligand (APRIL) in Colorectal Cancer
by Monika Zajkowska, Karolina Orywal and Mariusz Gryko
Int. J. Mol. Sci. 2024, 25(23), 12496; https://doi.org/10.3390/ijms252312496 - 21 Nov 2024
Viewed by 241
Abstract
APRIL (A proliferation-inducing ligand) is a member of the tumor necrosis factor superfamily that is overexpressed in a variety of malignant tumors, including colorectal cancer (CRC). Its key physiological roles include inducing the immunoglobulin switch and ensuring plasmocyte survival. In terms of pathological [...] Read more.
APRIL (A proliferation-inducing ligand) is a member of the tumor necrosis factor superfamily that is overexpressed in a variety of malignant tumors, including colorectal cancer (CRC). Its key physiological roles include inducing the immunoglobulin switch and ensuring plasmocyte survival. In terms of pathological roles, APRIL antagonism has been identified as a key target in autoimmune diseases and immunoglobulin disorders. As previously demonstrated, several inflammatory processes occur at the site of neoplastic initial stages, and their local symptoms are difficult to detect, particularly in the early stages. That is why we chose to study the current literature on APRIL’s role in the development of colorectal cancer. The main objective of our research was to investigate the role of APRIL in cancer initiation and its usefulness in the detection and therapy of CRC. Interestingly, the findings conducted so far show that the selected protein has a significant potential as a CRC biomarker and treatment target. Importantly, based on its concentration, it is possible to identify CRC patients, but whether the lesion has a benign or malignant nature, indicating the possibility of rapid detection of an ongoing disease process. Full article
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