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Bioactive Peptides in Human Health and Disease 2.0
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Bioactive Peptides in Human Health and Disease 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 4325

Special Issue Editors

Dr. Davide Tagliazucchi

E-Mail Website
Guest Editor
Department of Life Sciences, University of Modena and Reggio Emilia, 42121 Reggio, Italy
Interests: biological activity of (poly)phenols and their corresponding metabolites produced in the body; study of the molecular mechanisms of interaction between (poly)phenols and enzymes; identification and bioactivity of peptides produced after digestion of dietary protein
Special Issues, Collections and Topics in MDPI journals
Dr. Serena Martini

E-Mail Website
Guest Editor
Department of Life Sciences, University of Modena and Reggio Emilia, Via Amendola 2, 42100 Reggio Emilia, Italy
Interests: polyphenols; digestion; bioactive peptides
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Poor dietary habits and a sedentary lifestyle are widely established to be the major risk factors for the development of long-term chronic conditions, such as cardiovascular diseases, type 2 diabetes and cancer. In this framework, where a consumer’s food choices are even more influenced by an ever-growing awareness of nutritional, environmental, and health factors, the presence and identification of natural bioactive compounds are gaining increasing attention in the scientific community.

In recent years, scientific interest in bioactive peptides and their potential health benefits are greatly increased within the framework of health-promoting functional foods. The search for bioactive peptides has expanded exponentially due to the increased incidence of metabolic and cardiovascular diseases. Bioactive peptides show different bio-functional properties, and they can be used as additional components in functional foods, nutraceuticals, food-grade bio-preservatives, cosmetics, and pharmaceuticals. They may have important physiological functions, such as anti-hypertensive, anti-microbial, anti-thrombotic, immunomodulatory, opioid, antioxidant, and mineral binding activities.

This Special Issue, entitled “Bioactive Peptides in Human Health and Disease”, aims to collect research and review papers focusing on several aspects that are related to bioactive peptides and human health, including their in vitro and in vivo role in the prevention and treatment of chronic diseases, bioaccessibility and bioavailability, release and biological characterization of novel bioactive peptides, and in vitro mechanistic studies.

Dr. Davide Tagliazucchi
Dr. Serena Martini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • diabetes
  • cardiovascular diseases
  • peptidomics
  • food digestion
  • protein hydrolysates
  • antihypertensive peptides

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Published Papers (3 papers)

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Research

17 pages, 2078 KiB  
Article
Bis(Disulfide)-Bridged Somatostatin-14 Analogs and Their [111In]In-Radioligands: Synthesis and Preclinical Profile
by Aikaterini Tatsi, Theodosia Maina, Beatrice Waser, Eric P. Krenning, Marion de Jong, Jean Claude Reubi, Paul Cordopatis and Berthold A. Nock
Int. J. Mol. Sci. 2024, 25(3), 1921; https://doi.org/10.3390/ijms25031921 - 5 Feb 2024
Viewed by 1218
Abstract
The overexpression of one or more somatostatin receptors (SST1–5R) in human tumors has provided an opportunity for diagnosis and therapy with somatostatin-like radionuclide carriers. The application of “pansomatostatin” analogs is expected to broaden the clinical indications and upgrade the diagnostic/therapeutic efficacy [...] Read more.
The overexpression of one or more somatostatin receptors (SST1–5R) in human tumors has provided an opportunity for diagnosis and therapy with somatostatin-like radionuclide carriers. The application of “pansomatostatin” analogs is expected to broaden the clinical indications and upgrade the diagnostic/therapeutic efficacy of currently applied SST2R-prefering radioligands. In pursuit of this goal, we now introduce two bicyclic somatostatin-14 (SS14) analogs, AT5S (DOTA-Ala1-Gly2-c[Cys3-Lys4-Asn5-c[Cys6-Phe7-DTrp8-Lys9-Thr10-Cys11]-Thr12-Ser13-Cys14]) and AT6S (DOTA-Ala1-Gly2-c[Cys3-Lys4-c[Cys5-Phe6-Phe7-DTrp8-Lys9-Thr10-Phe11-Cys12]-Ser13-Cys14]), suitable for labeling with trivalent radiometals and designed to sustain in vivo degradation. Both AT5S and AT6S and the respective [111In]In-AT5S and [111In]In-AT6S were evaluated in a series of in vitro assays, while radioligand stability and biodistribution were studied in mice. The 8/12-mer bicyclic AT6S showed expanded affinity for all SST1–5R and agonistic properties at the SST2R, whereas AT5S lost all affinity to SST1–5R. Both [111In]In-AT5S and [111In]In-AT6S remained stable in the peripheral blood of mice, while [111In]In-AT6S displayed low, but specific uptake in AR4-2J tumors and higher uptake in HEK293-SST3R tumors in mice. In summary, high radioligand stability was acquired by the two disulfide bridges introduced into the SS14 motif, but only the 8/12-mer ring AT6S retained a pansomatostatin profile. In consequence, [111In]In-AT6S targeted SST2R-/SST3R-positive xenografts in mice. These results call for further research on pansomatostatin-like radioligands for cancer theranostics. Full article
(This article belongs to the Special Issue Bioactive Peptides in Human Health and Disease 2.0)
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14 pages, 1354 KiB  
Article
Coexistence of Cardiovascular Risk Factors and Blood Renalase Concentration
by Aleksandra Żórawik, Wojciech Hajdusianek, Iwona Markiewicz-Górka, Aleksandra Jaremków, Krystyna Pawlas, Helena Martynowicz, Grzegorz Mazur, Rafał Poręba and Paweł Gać
Int. J. Mol. Sci. 2023, 24(23), 16666; https://doi.org/10.3390/ijms242316666 - 23 Nov 2023
Viewed by 1063
Abstract
Cardiovascular diseases (CVDs) are one of the biggest health challenges facing health systems around the world. There are certain risk factors (CVRFs) that contribute to CVD. Risk factors associated with lifestyle such as tobacco consumption are particularly essential. Renalase is a recently discovered [...] Read more.
Cardiovascular diseases (CVDs) are one of the biggest health challenges facing health systems around the world. There are certain risk factors (CVRFs) that contribute to CVD. Risk factors associated with lifestyle such as tobacco consumption are particularly essential. Renalase is a recently discovered flavoprotein that may be involved in the progression of cardiometabolic diseases. The aim of the study was to investigate the relation between CVRFs and blood renalase concentration (BRC). The study group consisted of 96 people (51% women) who were hospitalized in the internal medicine department. CVRFs were measured using the AHA Life 7 scale. The E3109Hu ELISA kit was used to assess BRC. We found higher BRC in groups with a lower number of CVRFs (p < 0.05). We found a negative correlation between BRC and the number of CVRFs (r = −0.41). With the regression analysis, obesity, smoking, and a lack of physical activity (LoPE) were independently associated with lower blood renalase concentration. ROC analysis indicated the highest accuracy of BRC < 38.98 ng/mL in patients with ≥5 CVRFs. In conclusion, patients with a higher number of CVRFs had lower BRCs. The CVRFs particularly associated with a lower BRC were obesity, smoking, and LoPE. Full article
(This article belongs to the Special Issue Bioactive Peptides in Human Health and Disease 2.0)
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13 pages, 14106 KiB  
Article
Novel Antimicrobial Peptide from the Hepatopancreas of the Red King Crab
by Vladislav Molchanov, Alexander Yegorov, Maxim Molchanov, Alexander Timchenko, Vitaly Novikov, Nikolay Novojilov and Maria Timchenko
Int. J. Mol. Sci. 2023, 24(21), 15607; https://doi.org/10.3390/ijms242115607 - 26 Oct 2023
Cited by 2 | Viewed by 1392
Abstract
Crustaceans have successfully adapted to survive in their natural habitat, rich in microorganisms, due to the presence of antimicrobial peptides (AMPs) in their organism. They achieve this adaptation despite lacking the highly specific adaptive immune system found in vertebrates. One valuable source of [...] Read more.
Crustaceans have successfully adapted to survive in their natural habitat, rich in microorganisms, due to the presence of antimicrobial peptides (AMPs) in their organism. They achieve this adaptation despite lacking the highly specific adaptive immune system found in vertebrates. One valuable source of AMPs is the hepatopancreas, a waste product from crab fishery and its processing. Applying zymographic and spectrophotometric techniques, we discovered a small peptide (approximately 5 kDa) within a low molecular weight protein fraction extracted from the acetone powder of the red king crab hepatopancreas. This peptide hydrolyzes both M. lysodeikticus cell wall and M. lysodeikticus cell wall polysaccharide, while showing no activity against gelatin. The found peptide may be of interest for application in medicine, biotechnology, and the food industry, for example as a bio-preservative. Full article
(This article belongs to the Special Issue Bioactive Peptides in Human Health and Disease 2.0)
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