Oxidative Stress and Mitochondrial Dysfunction in Kidney Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 October 2023)
Special Issue Editors
Interests: renal diseases, oxidative stress, vitamins, glycemic response, mitochondrial function
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress and mitochondrial dysfunction play crucial roles in the pathogenesis of several diseases, wherein an imbalance occurs between the production of reactive oxygen species (ROS) and the cellular antioxidant defense mechanisms, leading to cellular damage. Kidneys are highly energy-demanding organs with abundant mitochondria, which are responsible for energy production through oxidative phosphorylation. However, in kidney diseases, various factors such as inflammation, ischemia-reperfusion injury, and metabolic disorders contribute to increased ROS production and impaired mitochondrial function. ROS can directly damage mitochondrial DNA, proteins, and lipids, resulting in mitochondrial dysfunction and exacerbating oxidative stress. Consequently, impaired mitochondrial function disrupts cellular metabolism, energy production, and cellular signaling pathways, ultimately driving the progression of kidney diseases, including chronic kidney disease, acute kidney injury, diabetic nephropathy, and other kidney disorders.
Understanding the interplay between oxidative stress and mitochondrial dysfunction is essential for identifying potential therapeutic targets and developing interventions to mitigate kidney disease progression. Strategies aimed at reducing oxidative stress and preserving mitochondrial function hold promise for the prevention and treatment of kidney diseases.
Therefore, we invite authors to contribute with high-quality original or review papers highlighting the role of mitochondria in modulating the pathophysiology of oxidative stress-related kidney diseases. Specifically, we encourage research on potential therapeutic agents and food-derived compounds that regulate molecular signaling of renal mitochondrial function.
Dr. Hsinjung Ho
Prof. Dr. Hitoshi Shirakawa
Guest Editors
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Keywords
- kidney diseases
- mitochondrial dynamics
- mitochondrial β-oxidation
- mitophagy
- oxidative phosphorylation
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