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Food Science and Molecular Nutrition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 2411

Special Issue Editor

Special Issue Information

Dear Colleagues,

Nowadays, extending our healthy lifespan is considered an important issue. A metabolic disorder occurs when abnormal chemical reactions disrupt the body’s metabolism. Acquired metabolic disorders are tightly associated with our daily food intake, which contributes to our health and plays a crucial role in the onset of several diseases. This disruption may result in an imbalance of essential nutrients or impaired nutrient utilization for health maintenance. Metabolic disorders are divided into various conditions, including the breakdown of amino acids, carbohydrates, or lipids. Moreover, mitochondrial dysfunction, which impacts cellular energy production, can also lead to metabolic disorders. Therefore, regulation of amino acids, carbohydrates, lipids metabolism, and mitochondrial function may play an important role in health maintenance.

Research in Food Science and Molecular Nutrition focuses on the effects of nutrients or food-derived bioactive compounds on gene expression, protein function, enzyme activity, and metabolic pathways in various tissues or cells. Understanding the interaction between nutrients (or food-derived bioactive compounds) and metabolic pathways could provide potential therapeutic approaches for mitigating the progression of diseases related to metabolic disorders, including liver failure, renal injury, type 2 diabetes, cardiovascular complications, and cancers.

We invite authors to contribute high-quality original research or review papers that highlight the beneficial functions of food-derived bioactive compounds in disease prevention or health management. Studies on the effects of food-derived bioactive compounds on molecular signaling in metabolic disorder-related diseases or mitochondrial dysfunction are particularly encouraged.

Dr. Hsinjung Ho
Guest Editor

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Keywords

  • food science
  • antioxidants
  • bioactive compounds
  • mitochondria
  • nutrigenomics
  • metabolomics

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Published Papers (1 paper)

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Review

17 pages, 1601 KiB  
Review
Effect of Abelmoschus esculentus L. (Okra) on Dyslipidemia: Systematic Review and Meta-Analysis of Clinical Studies
by Kabelo Mokgalaboni, Wendy N. Phoswa, Tyson T. Mokgalabone, Sanele Dlamini, Ashwell R. Ndhlala, Perpetua Modjadji and Sogolo L. Lebelo
Int. J. Mol. Sci. 2024, 25(20), 10922; https://doi.org/10.3390/ijms252010922 - 10 Oct 2024
Cited by 1 | Viewed by 1817
Abstract
The global prevalence of cardiovascular diseases (CVDs), including dyslipidemia and atherosclerosis, is rising. While pharmacological treatments for dyslipidemia and associated CVDs exist, not all individuals can afford them, and those who do often experience adverse side effects. Preclinical studies have indicated the potential [...] Read more.
The global prevalence of cardiovascular diseases (CVDs), including dyslipidemia and atherosclerosis, is rising. While pharmacological treatments for dyslipidemia and associated CVDs exist, not all individuals can afford them, and those who do often experience adverse side effects. Preclinical studies have indicated the potential benefits of Abelmoschus esculentus and its active phytochemicals in addressing dyslipidemia in rodent models of diabetes. However, there is limited clinical evidence on lipid parameters. Thus, this study aimed to assess the potential impact of Abelmoschus esculentus on dyslipidemia. A literature search was performed on PubMed, Scopus, and Cochrane Library for relevant trials published from inception until 11 August 2024. Data analysis was performed using Jamovi software version 2.4.8 and Review Manager (version 5.4), with effect estimates reported as standardized mean differences (SMDs) and 95% confidence intervals (CI). The evidence from eight studies with nine treatment arms showed that Abelmoschus esculentus reduces total cholesterol (TC), SMD = −0.53 (95% CI: −1.00 to −0.07), p = 0.025), compared to placebo. Additionally, triglyceride (TG) was reduced in Abelmoschus esculentus compared to placebo, SMD = −0.24 (95% CI: −0.46 to −0.02), p = 0.035. Furthermore, low-density lipoprotein (LDL) was also reduced, SMD = −0.35 (95% CI: −0.59 to −0.11), p = 0.004 in Abelmoschus esculentus versus placebo. This remedy substantially increased high-density lipoprotein (HDL), SMD = 0.34 (95% CI: 0.07 to 0.61), p = 0.014). Abelmoschus esculentus substantially improved lipid profile in prediabetes, T2D, obesity, and diabetic nephropathy. While the evidence confirms the potential benefits of Abelmoschus esculentus in reducing dyslipidemia, it is important for future clinical studies to standardize the effective dosage for more reliable results. Therefore, future trials should focus on these markers in well-designed trials with sufficient sample sizes. Furthermore, Abelmoschus esculentus can be supplemented to the diet of the relevant populations to alleviate dyslipidemia. Full article
(This article belongs to the Special Issue Food Science and Molecular Nutrition)
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