Epilepsy and Metabolism
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 10104
Special Issue Editor
Interests: voltage and ligand gated ion channel structure and function; channelopathies; signaling transduction; G-protein coupled receptors structure and function; epilepsy and metabolism; variants and pathogenic mutations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epilepsy and metabolic disorders can be considered one of the most extensive topics, where the minimum details of the pathophysiology of the disease and the molecular mechanisms that can explain its origin have yet to be discovered. It is interesting to note that although they may seem like two totally different themes, they have in common the biology that originates them. So far, more than thousands of variants have been described; monogenic mutations and de novo mutations can cause moderate to severe epileptic and eating disorders, obesity, and cachexia, in which G protein coupled receptor (GPCR) signaling, ion channels, accessory proteins, and downstream signaling appear to be involved in inhibiting/exciting key circuits that maintain homeostasis of neuronal excitability. Moreover, recent studies on the transcriptomic of specific neuronal groups in less studied physiological states, such as the pathways that regulate energy homeostasis, have revealed the appearance of less conventional modulators that govern neuronal tonic inhibition, and this could be part of the regulation of inhibitory/excitatory balance signaling in metabolic circuits. These facts paint the complex picture of the physiology of ion channels, GPCRs, and accessory proteins in the brain involved in such disorders.
The scope of the Special Issue involves bringing together original research and review articles on GPCRs, ion channels, accessory proteins, and downstream signaling in networks causing epileptic and metabolic disorders, and thus summarizing and expand our knowledge of signaling processes and networks and highlighting new advances and methodologies that will ultimately advance our understanding of the current state of cell signaling processes in which epilepsy and metabolism are involved.
Dr. Ciria C. Hernandez
Guest Editor
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Keywords
- inhibitory/excitatory balance
- epilepsy
- energy balance
- drug discovery
- GPCR
- ion channels
- obesity
- cachexia
- eating disorders
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