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Ion Channels in Eye Development, Health, and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 2488

Special Issue Editors


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Guest Editor
Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Interests: synaptic transmission; calcium and vesicle dynamics; retina; ribbon synapse; neurodegeneration

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Guest Editor
Department of Ophthalmology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Interests: inherited retinal dystrophies; age-related macular degeneration; glaucoma; gene therapy; inflammation
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Special Issue Information

Dear Colleagues,  

Ion channels are membrane-spanning multimeric proteins expressed by all living organisms and serve the purpose of transporting both organic and inorganic ions. The regulation of ions at a steady state level is a key phenomenon for proper cellular function. Recent advancements in imaging, physiology, crystallography, computational technology, molecular modeling, molecular biology tools, and systems genetics have facilitated an understanding of ion channels including the structure–function relationship of ion channels and the development of precision medicine.

The eye is an excellent model for understanding how the structure and function of ion channels correlate during development, health, and disease. This Special Issue aims to provide a comprehensive overview of the roles ion channels play from the perspective of the eye during development, health, disease, and potential therapeutic targets. This Special Issue welcomes original research papers, reviews, mini-reviews, perspectives, and opinion articles that will provide insights into the novel and existing approaches to:

  1. Explore specific roles of ion channels in development, health, and disease.
  2. Novel approaches to study the structure and function of ion channels.
  3. Current understanding of channelopathies and drug development.
  4. Studies in all animal species and models of retinal diseases are welcome, as are comparative studies across animal models.

Dr. Thirumalini Vaithianathan
Dr. T. J. Hollingsworth
Guest Editors

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Keywords

  • eye development
  • eye health and disease
  • ion channels
  • channelopathies
  • physiology
  • computational technology
  • molecular modeling
  • molecular biology tools
  • pharmacology
  • systems genetics

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Published Papers (1 paper)

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Review

35 pages, 4883 KiB  
Review
The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease
by Johane M. Boff, Abhishek P. Shrestha, Saivikram Madireddy, Nilmini Viswaprakash, Luca Della Santina and Thirumalini Vaithianathan
Int. J. Mol. Sci. 2024, 25(4), 2226; https://doi.org/10.3390/ijms25042226 - 13 Feb 2024
Cited by 1 | Viewed by 1985
Abstract
The intricate functionality of the vertebrate retina relies on the interplay between neurotransmitter activity and calcium (Ca2+) dynamics, offering important insights into developmental processes, physiological functioning, and disease progression. Neurotransmitters orchestrate cellular processes to shape the behavior of the retina under [...] Read more.
The intricate functionality of the vertebrate retina relies on the interplay between neurotransmitter activity and calcium (Ca2+) dynamics, offering important insights into developmental processes, physiological functioning, and disease progression. Neurotransmitters orchestrate cellular processes to shape the behavior of the retina under diverse circumstances. Despite research to elucidate the roles of individual neurotransmitters in the visual system, there remains a gap in our understanding of the holistic integration of their interplay with Ca2+ dynamics in the broader context of neuronal development, health, and disease. To address this gap, the present review explores the mechanisms used by the neurotransmitters glutamate, gamma-aminobutyric acid (GABA), glycine, dopamine, and acetylcholine (ACh) and their interplay with Ca2+ dynamics. This conceptual outline is intended to inform and guide future research, underpinning novel therapeutic avenues for retinal-associated disorders. Full article
(This article belongs to the Special Issue Ion Channels in Eye Development, Health, and Disease)
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