Current Insights into the Neuronal Calcium Sensor DREAM and Related KChIP Proteins
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 4221
Special Issue Editors
Interests: calcium and protein homeostasis
Special Issue Information
Dear Colleagues,
The neuronal calcium sensor DREAM, also known as calsenilin or KChIP3, is a multifunctional protein widely expressed in the CNS and peripheral organs. DREAM activities are determined by specific protein–DNA and protein–protein interactions in specific subcellular compartments in a wide variety of cellular types, both in adulthood and during development. Importantly, the binding of divalent ions, lipids and small molecules to DREAM changes its conformation and impacts it ability to interact with other macromolecules. Thus, the activity of DREAM could be modulated both physiologically and pharmacologically.
In this Special Issue, we would like to recapitulate recent advances in all aspects concerning DREAM and related KChIP1, 2 and 4 proteins. This includes similarities and specificities in their regulation and their functions in health and disease, as well as new developments in the binding molecules able to alter their activity.
Prof. Dr. Jose R. Naranjo
Dr. Jaroslava Miksovska
Guest Editors
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Keywords
- calcium homeostasis
- protein–protein interactions
- EF-hands
- neurodegeneration
- fibrosis
- DREAM ligands
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