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Retinal Diseases: From Molecular Pathology to Therapies—2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 December 2024 | Viewed by 725

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Guest Editor
Departments of Ophthalmology and Basic Medical Science, School of Medicine, University of Missouri, 2411 Holmes Street, Kansas City, MO 64108, USA
Interests: drug target discovery and drug development for disorders of the CNS and retina; calcium signaling; neuroprotection; neurodegeneration; synaptic signaling; neurophysiology
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Special Issue Information

Dear Colleagues,

The identification of mechanisms underlying the pathophysiology and therapies of retinal diseases continues to be an area of significant research activity, attracting scientists from a diverse range of fields, including neuroscience, pharmacology, and medicinal chemistry, among several others. With the ultimate goal of generating intervention strategies that slow or even reverse the structural and functional degeneration of the retina and that attenuate or eliminate subsequent vision loss, with input from numerous fields, such as neurology, ophthalmology, genetics, and neuroscience, effective therapies for many retinal diseases are lacking and critically needed.

Research efforts towards preventing, treating, or curing retinal diseases are characteristic for how clinical practice as well as basic and translational research inform each other and how such interactions can result in novel therapeutic strategies of high clinical relevance. Recent methodological advances in synthetic and medicinal chemistry, mass spectrometry, proteomics, drug target discovery, and drug development have generated significant developments in this field. Therefore, this Special Issue invites manuscript submissions, namely research and review papers, targeting the gamut of methodological and scientific innovation in this field. This Special Issue specifically calls for papers focused on the discovery and mechanistic characterization of novel drug targets, signaling pathways, and mechanisms of action, as they are relevant for retinal diseases. These contributions can be general and broad in their basic science, and translational research can focus more on specific research models related to the structural and functional degeneration of the retina and related complications.

Prof. Dr. Peter Koulen
Guest Editor

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Keywords

  • diabetic retinopathy
  • age-related macular degeneration
  • neuroprotection
  • retina
  • diabetic macular edema
  • therapy development
  • pathophysiology
  • retinitis pigmentosa
  • aging
  • eye trauma
  • vitreous
  • macula
  • choroideremia
  • stargardt disease
  • cone–rod dystrophy

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Published Papers (1 paper)

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Research

15 pages, 1583 KiB  
Article
Proteomics Analysis on the Effects of Oxidative Stress and Antioxidants on Proteins Involved in Sterol Transport and Metabolism in Human Telomerase Transcriptase-Overexpressing-Retinal Pigment Epithelium Cells
by R. Scott Duncan, Andrew Keightley, Adam A. Lopez, Conner W. Hall and Peter Koulen
Int. J. Mol. Sci. 2024, 25(20), 10893; https://doi.org/10.3390/ijms252010893 - 10 Oct 2024
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Abstract
Age-related macular degeneration (AMD) is the most prevalent ocular disease in the elderly, resulting in blindness. Oxidative stress plays a role in retinal pigment epithelium (RPE) pathology observed in AMD. Tocopherols are potent antioxidants that prevent cellular oxidative damage and have been shown [...] Read more.
Age-related macular degeneration (AMD) is the most prevalent ocular disease in the elderly, resulting in blindness. Oxidative stress plays a role in retinal pigment epithelium (RPE) pathology observed in AMD. Tocopherols are potent antioxidants that prevent cellular oxidative damage and have been shown to upregulate the expression of cellular antioxidant proteins. Here, we determined whether oxidative stress and tocopherols, using either normal cellular conditions or conditions of sublethal cellular oxidative stress, alter the expression of proteins mediating sterol uptake, transport, and metabolism. Human telomerase transcriptase-overexpressing RPE cells (hTERT-RPE) were used to identify differential expression of proteins resulting from treatments. We utilized a proteomics strategy to identify protein expression changes in treated cells. After the identification and organization of data, we divided the identified proteins into groups related to biological function: cellular sterol uptake, sterol transport and sterol metabolism. Exposure of cells to conditions of oxidative stress and exposure to tocopherols led to similar protein expression changes within these three groups, suggesting that α-tocopherol (αT) and γ-tocopherol (γT) can regulate the expression of sterol uptake, transport and metabolic proteins in RPE cells. These data suggest that proteins involved in sterol transport and metabolism may be important for RPE adaptation to oxidative stress, and these proteins represent potential therapeutic targets. Full article
(This article belongs to the Special Issue Retinal Diseases: From Molecular Pathology to Therapies—2nd Edition)
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