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New Research on Complexes of Nanoparticles and Bioreceptors: Obtaining, Characterization...
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New Research on Complexes of Nanoparticles and Bioreceptors: Obtaining, Characterization and Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 5714

Special Issue Editors

Dr. Irina Safenkova

E-Mail Website
Guest Editor
A.N. Bach Institute of Biochemistry, Research Centre of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia
Interests: nanoparticles; nanoparticle–bioreceptor conjugates; nanozymes; biosensors; immunoassay; isothermal amplification; recombinase polymerase amplification; loop-mediated amplification; CRISPR/Cas; amplification approaches for biosensors
Dr. Yi Wan

E-Mail Website
Guest Editor
State Key Laboratory of Marine Resource Utilization in South China Sea, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China
Interests: biosensors; microbiological diagnostic mechanisms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Combining nanoparticles and biomolecules into hybrid structures (conjugates) provides powerful tools for managing delivery, recognition, and detection processes, applicable both in vitro and in vivo. Updating in research and gaining new knowledge about nanoparticles as a career for bioreceptor molecules is necessary due to significant progress in the synthesis of new types of nanoparticles, the extension of used bioreceptor molecules, and innovative tools for high-throughput studies at a molecular level. Accordingly, the priority focus of our special issue is new nanoparticles, biomolecules, and approaches for their characterization.

In this Special Issue, we will consider the progress towards

  • obtaining nanoparticles used as carriers for bioreceptor molecules;
  • characterization and improving the properties of conjugates of nanoparticles with antibodies, aptamers, nucleic acids, enzymes, and other biomolecules;
  • theoretical and experimental studies of composition - property correlations for the nanoparticle–bioreceptor conjugates;
  • application of the nanoparticle–bioreceptor conjugates in diagnostics, delivery, and therapy.

This Special Issue aims at expanding the knowledge on obtaining, characterization, and applications for nanoparticles–bioreceptor conjugates. Experimental studies in biochemistry, molecular biology, biotechnology, and biomedicine, review articles, and clinical studies are all welcome for consideration.

Dr. Irina Safenkova
Dr. Yi Wan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanozymes
  • fluorescent nanoparticles
  • aggregates of nanoparticles
  • antibody
  • aptamer
  • nanoparticle–bioreceptor conjugates
  • protein corona
  • nanoparticle-based biosensors
  • enhanced immunoassays
  • isothermal amplification
  • nanoparticle-based therapy
  • nanoparticle-based delivery
  • nanotheranostics

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Published Papers (3 papers)

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Research

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27 pages, 7152 KiB  
Article
Preparation and Pharmacokinetics of Brain-Targeted Nanoliposome Loaded with Rutin
by Changxu Wu, Jinwu Zhang, Shisen Yang, Chunzi Peng, Maojie Lv, Jing Liang, Xiaoning Li, Liji Xie, Yingyi Wei, Hailan Chen, Jiakang He, Tingjun Hu, Zhixun Xie and Meiling Yu
Int. J. Mol. Sci. 2024, 25(21), 11404; https://doi.org/10.3390/ijms252111404 - 23 Oct 2024
Viewed by 607
Abstract
Rutin is a flavonoid compound with potential for treating Alzheimer’s disease, preventing brain damage, mitigating cerebral ischemia–reperfusion injury, and exhibiting anti-glioblastoma activity. However, its efficacy is limited by its low solubility, poor bioavailability, and limited permeability across the blood–brain barrier (BBB). To enhance [...] Read more.
Rutin is a flavonoid compound with potential for treating Alzheimer’s disease, preventing brain damage, mitigating cerebral ischemia–reperfusion injury, and exhibiting anti-glioblastoma activity. However, its efficacy is limited by its low solubility, poor bioavailability, and limited permeability across the blood–brain barrier (BBB). To enhance the bioavailability and brain-targeting ability of Rutin, transferrin-modified Rutin liposome (Tf-Rutin-Lip) was developed using liposomes as a delivery system. Rutin liposomes were prepared using the thin-film dispersion method, and the preparation conditions were optimized using the response surface methodology. Then, transferrin (Tf) was incorporated into the liposomes through covalent modification, yielding Tf-Rutin liposomes. The toxicity of these liposomes on bEnd.3 cells, as well as their impact on the tight junctions of these cells, was rigorously evaluated. Additionally, in vitro and in vivo experiments were conducted to validate the brain-targeting efficacy of the Tf-Rutin liposomes. A susceptible detection method was developed to characterize the pharmacokinetics of Tf-Rutin-Lip further. The optimized conditions for the preparation of Tf-Rutin-Lip were determined as follows: a lipid-to-cholesterol ratio of 4.63:1, a drug-to-lipid ratio of 1:45.84, a preparation temperature of 42.7 °C, a hydration volume of 20 mL, a sonication time of 10 min, a surfactant concentration of 80 mg/mL, a DSPE-MPEG-2000 concentration of 5%, and a DSPE-PEG2000-COOH to DSPE-MPEG-2000 molar ratio of 10%. The liposomes did not affect the cell activity of bEnd.3 cells at 24 h and did not disrupt the tight junction of the blood–brain barrier. Tf-modified liposomes were taken up by bEnd.3 cells, which, in turn, passed through the BBB, thus improving liposomal brain targeting. Furthermore, the results of pharmacokinetic experiments showed that the Cmax, AUC0-∞, AUC0-t, MRT0-∞, and t1/2 of Tf-Rutin-Lip increased 1.99-fold, 2.77-fold, 2.58-fold, 1.26-fold, and 1.19-fold compared to those of free Rutin solution, respectively. These findings suggest that Tf-Rutin-Lip is brain-targeted and may enhance the efficacy of Rutin in the treatment of brain disorders. Full article
(This article belongs to the Special Issue New Research on Complexes of Nanoparticles and Bioreceptors: Obtaining, Characterization and Applications)
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12 pages, 6062 KiB  
Article
Visual Detection of Dopamine with CdS/ZnS Quantum Dots Bearing by ZIF-8 and Nanofiber Membranes
by Jiadong Hu, Jiaxin Li, Qunqun Guo, Guicai Du, Changming Li, Ronggui Li, Rong Zhou and Hongwei He
Int. J. Mol. Sci. 2024, 25(19), 10346; https://doi.org/10.3390/ijms251910346 - 26 Sep 2024
Viewed by 632
Abstract
Dopamine (DA) is a widely present, calcium cholinergic neurotransmitter in the body, playing important roles in the central nervous system and cardiovascular system. Developing fast and sensitive DA detection methods is of great significance. Fluorescence-based methods have attracted much attention due to their [...] Read more.
Dopamine (DA) is a widely present, calcium cholinergic neurotransmitter in the body, playing important roles in the central nervous system and cardiovascular system. Developing fast and sensitive DA detection methods is of great significance. Fluorescence-based methods have attracted much attention due to their advantages of easy operation, a fast response speed, and high sensitivity. This study prepared hydrophilic and high-performance CdS/ZnS quantum dots (QDs) for DA detection. The waterborne CdS/ZnS QDs were synthesized in one step using the amphiphilic polymer PEI-g-C14, obtained by grafting tetradecane (C14) to polyethyleneimine (PEI), as a template. The polyacrylonitrile nanofiber membrane (PAN-NFM) was prepared by electrospinning (e-spinning), and a metal organic frame (ZIF-8) was deposited in situ on the surface of the PAN-NFM. The CdS/ZnS QDs were loaded onto this substrate (ZIF-8@PAN-NFM). The results showed that after the deposition of ZIF-8, the water contact angle of the hydrophobic PAN-NFM decreased to within 40°. The nanofiber membrane loaded with QDs also exhibited significant changes in fluorescence in the presence of DA at different concentrations, which could be applied as a fast detection method of DA with high sensitivity. Meanwhile, the fluorescence on this PAN-NFM could be visually observed as it transitioned from a blue-green color to colorless, making it suitable for the real-time detection of DA. Full article
(This article belongs to the Special Issue New Research on Complexes of Nanoparticles and Bioreceptors: Obtaining, Characterization and Applications)
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Review

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29 pages, 4493 KiB  
Review
CRISPR/Cas-Based Techniques for Live-Cell Imaging and Bioanalysis
by Shuo Huang, Rui Dai, Zhiqi Zhang, Han Zhang, Meng Zhang, Zhangjun Li, Kangrui Zhao, Wenjun Xiong, Siyu Cheng, Buhua Wang and Yi Wan
Int. J. Mol. Sci. 2023, 24(17), 13447; https://doi.org/10.3390/ijms241713447 - 30 Aug 2023
Cited by 4 | Viewed by 3759
Abstract
CRISPR/Cas systems have found widespread applications in gene editing due to their high accuracy, high programmability, ease of use, and affordability. Benefiting from the cleavage properties (trans- or cis-) of Cas enzymes, the scope of CRISPR/Cas systems has expanded beyond gene [...] Read more.
CRISPR/Cas systems have found widespread applications in gene editing due to their high accuracy, high programmability, ease of use, and affordability. Benefiting from the cleavage properties (trans- or cis-) of Cas enzymes, the scope of CRISPR/Cas systems has expanded beyond gene editing and they have been utilized in various fields, particularly in live-cell imaging and bioanalysis. In this review, we summarize some fundamental working mechanisms and concepts of the CRISPR/Cas systems, describe the recent advances and design principles of CRISPR/Cas mediated techniques employed in live-cell imaging and bioanalysis, highlight the main applications in the imaging and biosensing of a wide range of molecular targets, and discuss the challenges and prospects of CRISPR/Cas systems in live-cell imaging and biosensing. By illustrating the imaging and bio-sensing processes, we hope this review will guide the best use of the CRISPR/Cas in imaging and quantifying biological and clinical elements and inspire new ideas for better tool design in live-cell imaging and bioanalysis. Full article
(This article belongs to the Special Issue New Research on Complexes of Nanoparticles and Bioreceptors: Obtaining, Characterization and Applications)
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