New Technology of Biomarker Detection Based on Microbial-Derived Biosensors
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 3026
Special Issue Editor
Interests: biosensors; microbiological diagnostic mechanisms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Through millions of years of evolution, microorganisms have developed defense systems to protect them from attack by invading species (e.g., CRISPR-Cas for establishing adaptive immune systems and nanopore-forming toxins as virulence factors) or enable them to adapt to different conditions (e.g., gas vesicles for achieving buoyancy control). These microorganism defense systems (MDSs) have inspired the development of biosensors, receiving much attention in many fields ranging from life science research to food safety to medical diagnosis.
Compared to nanomaterial-based biosensors, MDS-derived next-generation biosensing methods provide excellent results with high sensitivity and specificity and, in combination with fluorescent, electrochemical, colorimetric and acoustic devices, offer an important analytical tool for the low-cost measurement of nucleic acids, protein, bacteria cells, small molecules and metal ions. The low-cost nature of these techniques is facilitated by their scalability, as the production of microorganisms, proteins or DNA can be easily scaled up to adjust to the market needs by simply using larger or more bioreactors. Paper-based detection methods are not only easy to scale up, but also cheap to store and deliver, able to be dried and preserved for long term with no need for refrigeration.
We invite research submissions helping towards advancing the field of MDS-derived next-generation biosensing and its application for the high-throughput analysis of biomarkers.
Dr. Yi Wan
Guest Editor
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Keywords
- microbe-derived biosensors
- CRISPR-Cas system
- nucleic acid diagnostic
- nanopore
- gas vesicles
- bacteria detection
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