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Novel Pharmacology of Diabetic Complications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 6754

Special Issue Editors

Department of Clinical, Pharmaceutical and Biological Science, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK
Interests: translational pharmacology; novel mechanisms; biomarkers and treatments of diabetes complications; neuropathy; neuropathic pain; retinopathy

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Guest Editor
School of Science & Technology, Nottingham Trent University, Nottingham NG11 8N5, UK
Interests: neurophysiology of chronic pain; diabetic neuropathic pain

Special Issue Information

Dear Colleagues,

Diabetes mellitus (DM) is a common endocrine disease and major health problem across the globe. If left untreated, DM can lead to many health complications that adversely affect multiple organs or tissues, such as the kidney, heart, cardiovascular system, eyes, and nervous system. Common diabetic complications include nephropathy, retinopathy, neuropathy, neuropathic pain, and cardiovascular diseases, which can seriously impair quality of life and cause long-lasting disability, and they are often resistant to existing treatment, posing a huge economic burden on health systems and society.

Understanding the pathological basis of diabetes’ effects on different organ systems has become a cornerstone of the treatment of diabetic complications. This information helps researchers to identify potential novel drug targets at the molecular and cellular levels. This Special Issue focuses on understanding the novel pharmacological mechanisms that drive diabetes’ complications. In addition, novel therapies for diabetic complications, such as phytochemicals, gene therapy, RNA therapy, etc., are welcome. Papers with a molecular orientation will be considered for publication in this Special Issue, but clinical papers are discouraged by IJMS.

Dr. Lisa Lione
Dr. Richard Hulse
Guest Editors

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Keywords

  • diabetes mellitus
  • complication
  • pathophysiology
  • mechanism
  • therapeutic strategies

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Published Papers (1 paper)

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Review

33 pages, 1519 KiB  
Review
Recent Advances in the Management of Diabetic Kidney Disease: Slowing Progression
by Na Wang and Chun Zhang
Int. J. Mol. Sci. 2024, 25(6), 3086; https://doi.org/10.3390/ijms25063086 - 7 Mar 2024
Cited by 6 | Viewed by 5294
Abstract
Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD), and it heightens the risk of cardiovascular incidents. The pathogenesis of DKD is thought to involve hemodynamic, inflammatory, and metabolic factors that converge on the fibrotic pathway. Genetic predisposition and [...] Read more.
Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD), and it heightens the risk of cardiovascular incidents. The pathogenesis of DKD is thought to involve hemodynamic, inflammatory, and metabolic factors that converge on the fibrotic pathway. Genetic predisposition and unhealthy lifestyle practices both play a significant role in the development and progression of DKD. In spite of the recent emergence of angiotensin receptors blockers (ARBs)/angiotensin converting enzyme inhibitor (ACEI), sodium-glucose cotransporter 2 (SGLT2) inhibitors, and nonsteroidal mineralocorticoid receptors antagonists (NS-MRAs), current therapies still fail to effectively arrest the progression of DKD. Glucagon-like peptide 1 receptor agonists (GLP-1RAs), a promising class of agents, possess the potential to act as renal protectors, effectively slowing the progression of DKD. Other agents, including pentoxifylline (PTF), selonsertib, and baricitinib hold great promise as potential therapies for DKD due to their anti-inflammatory and antifibrotic properties. Multidisciplinary treatment, encompassing lifestyle modifications and drug therapy, can effectively decelerate the progression of DKD. Based on the treatment of heart failure, it is recommended to use multiple drugs in combination rather than a single-use drug for the treatment of DKD. Unearthing the mechanisms underlying DKD is urgent to optimize the management of DKD. Inflammatory and fibrotic factors (including IL-1, MCP-1, MMP-9, CTGF, TNF-a and TGF-β1), along with lncRNAs, not only serve as diagnostic biomarkers, but also hold promise as therapeutic targets. In this review, we delve into the potential mechanisms and the current therapies of DKD. We also explore the additional value of combing these therapies to develop novel treatment strategies. Drawing from the current understanding of DKD pathogenesis, we propose HIF inhibitors, AGE inhibitors, and epigenetic modifications as promising therapeutic targets for the future. Full article
(This article belongs to the Special Issue Novel Pharmacology of Diabetic Complications)
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