High-Density Lipoprotein in Cardiovascular Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 7124
Special Issue Editor
Special Issue Information
Dear Colleagues,
The fatty streak develops as a response to specific lipids that are carried into the artery wall with LDL and that subsequently become oxidized as a result of exposure to the oxidative waste of the artery wall cells (the Yang). The opposing (calming) forces (the Yin) include the antioxidants present both within the LDL and within the microenvironments where the LDL is trapped. These antioxidants function to prevent the formation of the oxidized lipids. Other opposing (calming) forces include specific enzymes contained within LDL or associated with HDL that inactivate these biologically active lipids. The balance between the Yin and the Yang determines the response of the artery wall.
The effect of life style on lipoprotein metabolism, systemic inflammation and cardiovascular well being is well known. Nutritional habits, physical activity, normal sleep and optimal physical and mental pressure play major role in achieving a healthy and smart life style.
The anti oxidant, anti inflammatory HDL in the basal state contains enzymes that can destroy oxidized lipids that mediate a chronic inflammatory response. In this sense, HDL in the basal state is anti-inflammatory. Our group has shown that the alterations in HDL that were induced by the acute-phase response. The acute-phase response is a systemic reaction to infectious and noninfectious tissue-destructive processes. Unlike LDL, HDL is chameleon-like, changing its colors (apoproteins and associated enzymes) as the landscape changes (going from the basal state to the acute-phase response and back to the basal state). If HDL protection is largely due to its ability to inhibit or destroy the biologically active lipids in mildly oxidized LDL, the changes in HDL induced by the acute-phase response could result in an increase in the local modification (oxidation) of LDL in the artery wall. Consequently, monocyte infiltration at such sites may increase during an acute-phase response. The major site of monocyte entry into lipid-rich plaques that are prone to rupture is at the shoulder region of lesions, and the major determinant of plaque rupture appears to be the intensity of monocyte infiltration at such sites.
In this issue factors including nutritional habits, physical activity, good sleep, stress management and HDL in menopause will be covered.
Prof. Dr. Mohamad Navab
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- nutrition and HDL
- physical activity and HDL
- sleep and HDL
- stress and HDL
- genetics and HDL
- therapeutic approach to HDL abnormality
- dysfunctional HDL
- HDL levels vs HDL function
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
