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Advanced Research on Macrophages in Human Health and Disease
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Advanced Research on Macrophages in Human Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 3033

Special Issue Editor

Prof. Dr. María Martínez-Esparza

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, Health Science Campus, El Palmar, E-30120 Murcia, Spain
Interests: innate immune system in host–pathogen interactions; inflammatory and immune-related human pathologies such as cirrhosis, cancer, and endometriosis; microbiome; development of novel therapeutic approaches to treat that type of diseases; testing vegetal bioactive compounds and newly synthesized drugs; human monocyte and macrophages in in vitro assays; mouse animal models

Special Issue Information

Dear Colleagues,

Macrophages are innate immune cells found in all tissues that show great plasticity and functional diversity; they are involved in development, homeostasis, tissue repair, and immunity. However, these functions can be subverted, resulting in a causal association of macrophages with disease states, making them important therapeutic targets in many human diseases.

In this Special Issue of IJMS, we will focus on the physiological functions of human macrophages developed under healthy conditions at the molecular level, the mechanisms involved in disease establishment and/or progression, and how some of these mechanisms could be exploited therapeutically. We will consider submissions of original research reports, reviews, and methodology articles.

Prof. Dr. María Martínez-Esparza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • macrophages
  • phenotype
  • plasticity
  • inflammation
  • molecular mechanisms
  • signaling pathways
  • human disease
  • immunopathology
  • immunotherapy
  • target identification
  • natural compounds
  • drugs

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Published Papers (2 papers)

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34 pages, 6053 KiB  
Article
Insights into the Identification of iPSC- and Monocyte-Derived Macrophage-Polarizing Compounds by AI-Fueled Cell Painting Analysis Tools
by Johanna B. Brüggenthies, Jakob Dittmer, Eva Martin, Igor Zingman, Ibrahim Tabet, Helga Bronner, Sarah Groetzner, Julia Sauer, Mozhgan Dehghan Harati, Rebekka Scharnowski, Julia Bakker, Katharina Riegger, Caroline Heinzelmann, Birgit Ast, Robert Ries, Sophie A. Fillon, Anna Bachmayr-Heyda, Kerstin Kitt, Marc A. Grundl, Ralf Heilker, Lina Humbeck, Michael Schuler and Bernd Weigleadd Show full author list remove Hide full author list
Int. J. Mol. Sci. 2024, 25(22), 12330; https://doi.org/10.3390/ijms252212330 - 17 Nov 2024
Viewed by 697
Abstract
Macrophage polarization critically contributes to a multitude of human pathologies. Hence, modulating macrophage polarization is a promising approach with enormous therapeutic potential. Macrophages are characterized by a remarkable functional and phenotypic plasticity, with pro-inflammatory (M1) and anti-inflammatory (M2) states at the extremes of [...] Read more.
Macrophage polarization critically contributes to a multitude of human pathologies. Hence, modulating macrophage polarization is a promising approach with enormous therapeutic potential. Macrophages are characterized by a remarkable functional and phenotypic plasticity, with pro-inflammatory (M1) and anti-inflammatory (M2) states at the extremes of a multidimensional polarization spectrum. Cell morphology is a major indicator for macrophage activation, describing M1(-like) (rounded) and M2(-like) (elongated) states by different cell shapes. Here, we introduced cell painting of macrophages to better reflect their multifaceted plasticity and associated phenotypes beyond the rigid dichotomous M1/M2 classification. Using high-content imaging, we established deep learning- and feature-based cell painting image analysis tools to elucidate cellular fingerprints that inform about subtle phenotypes of human blood monocyte-derived and iPSC-derived macrophages that are characterized as screening surrogate. Moreover, we show that cell painting feature profiling is suitable for identifying inter-donor variance to describe the relevance of the morphology feature ‘cell roundness’ and dissect distinct macrophage polarization signatures after stimulation with known biological or small-molecule modulators of macrophage (re-)polarization. Our novel established AI-fueled cell painting analysis tools provide a resource for high-content-based drug screening and candidate profiling, which set the stage for identifying novel modulators for macrophage (re-)polarization in health and disease. Full article
(This article belongs to the Special Issue Advanced Research on Macrophages in Human Health and Disease)
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17 pages, 11954 KiB  
Article
Mmp12 Is Translationally Regulated in Macrophages during the Course of Inflammation
by Silvia Kuntschar, Giulia Cardamone, Kevin Klann, Rebekka Bauer, Sofie Patrizia Meyer, Rebecca Raue, Peter Rappl, Christian Münch, Bernhard Brüne and Tobias Schmid
Int. J. Mol. Sci. 2023, 24(23), 16981; https://doi.org/10.3390/ijms242316981 - 30 Nov 2023
Cited by 2 | Viewed by 1495
Abstract
Despite the importance of rapid adaptive responses in the course of inflammation and the notion that post-transcriptional regulation plays an important role herein, relevant translational alterations, especially during the resolution phase, remain largely elusive. In the present study, we analyzed translational changes in [...] Read more.
Despite the importance of rapid adaptive responses in the course of inflammation and the notion that post-transcriptional regulation plays an important role herein, relevant translational alterations, especially during the resolution phase, remain largely elusive. In the present study, we analyzed translational changes in inflammatory bone marrow-derived macrophages upon resolution-promoting efferocytosis. Total RNA-sequencing confirmed that apoptotic cell phagocytosis induced a pro-resolution signature in LPS/IFNγ-stimulated macrophages (Mϕ). While inflammation-dependent transcriptional changes were relatively small between efferocytic and non-efferocytic Mϕ; considerable differences were observed at the level of de novo synthesized proteins. Interestingly, translationally regulated targets in response to inflammatory stimuli were mostly downregulated, with only minimal impact of efferocytosis. Amongst these targets, pro-resolving matrix metallopeptidase 12 (Mmp12) was identified as a translationally repressed candidate during early inflammation that recovered during the resolution phase. Functionally, reduced MMP12 production enhanced matrix-dependent migration of Mϕ. Conclusively, translational control of MMP12 emerged as an efficient strategy to alter the migratory properties of Mϕ throughout the inflammatory response, enabling Mϕ migration within the early inflammatory phase while restricting migration during the resolution phase. Full article
(This article belongs to the Special Issue Advanced Research on Macrophages in Human Health and Disease)
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