Molecular Imaging in Precision Medicine: A Challenging Alliance
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 5417
Special Issue Editors
Interests: environmental pollution; oncology; cardiovascular diseases; electron microscopy; histology
Special Issues, Collections and Topics in MDPI journals
Interests: FDG PET/CT; oncology; therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Precision medicine represents a novel and revolutionary approach, by which a specific treatment is tailored on the basis of each patient’s epigenetic, molecular and environmental characteristics. In this regard, several therapies targeting specific molecular mechanisms have been implemented in clinical practice, such as those directed towards BRAF/MEK pathway in malignant melanoma or the PARP inhibitor olaparib in prostate cancer bearing defects of DNA repair genes. In order to define patients’ eligibility for these targeted treatments, complex molecular analyses need to be performed on biological samples with the aim of disclosing specific biomarkers associated with the disease. Notably, this tailored approach is also gaining consideration in medical fields others than oncology. We need to think, for example, to the recent FDA authorization of aducanumab specifically targeting amyloid deposition in Alzheimer’s disease.
In this scenario, novel imaging techniques provide a unique opportunity to investigate disease at a molecular level in order to obtain an in vivo characterization. Furthermore, this approach can be applied in a dynamic fashion, using different imaging probes to follow disease evolution during therapy, thus promptly detecting the onset of resistance to a specific drug. Molecular imaging through different techniques (SPECT/CT, PET/CT, optical imaging) has been applied in the field of precision medicine with promising results. In the present Special Issue, we solicit original studies or review articles highlighting the challenging alliance between molecular imaging and precision medicine, with a particular emphasis on the ongoing studies in the less-explored scientific fields, such as the emerging applications of nanotechnology and nanomedicine.
Dr. Manuel Scimeca
Prof. Dr. Luca Filippi
Guest Editors
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Keywords
- precision medicine
- oncology
- molecular imaging
- molecular biology
- molecular pathology
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