Mitochondrial Proteomics in Neuroscience and Neurodegenerative Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 5000
Special Issue Editors
Interests: hydrogen sulfide; metabolomics; mitochondrial biochemistry; neurodegenerative diseases; oxidative stress; proteomics; PTMs; redox dysregulation; sulfur species
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Mitochondria play a key role as energy mediators and in the biosynthesis of eukaryotic cells, so they are recognized as the cell’s powerhouse. In addition to this function in cellular bioenergetics, mitochondria are involved in several other pathways such as the regulation of cell death processes, the modulation of ionic homeostasis, and the oxidation of carbohydrates and fatty acids. Therefore, it is not surprising that mitochondrial dysfunctions or alterations can have a serious impact both in defects of energy metabolism and in the multifactorial diseases in which they are directly involved.
The involvement of mitochondria in the pathogenic mechanisms of neurodegenerative disorders (for example amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s diseases, and Down’s syndrome) has been well established. In recent years, many efforts have been made to understand these mechanisms, especially through the advances of the omics sciences.
From this perspective, mitochondria have become a “hotspot” for subcellular proteomics, with the aim of identifying clinical targets as candidate biomarkers in neurodegenerative diseases.
The purpose of this Special Issue is to gather the latest information and highlight the state of the art in the progress of mitochondrial proteomics in order to highlight yet-unknown aspects, or to clarify the complex mechanisms, linked to mitochondrial dysfunction in neurodegenerative diseases.
Reviews, commentaries, and original research based on proteomics and mass spectrometry are welcome (for example, discovery, quantitative aspects, PTMs, and redox proteomics), independently or in combination with other, more classic biochemical, molecular, and cellular approaches.
Dr. Viviana Greco
Dr. Luisa Pieroni
Guest Editors
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Keywords
- Proteomics
- Mass Spectrometry
- Mitochondria
- Mitochondria Function
- Neurodegeneration
- Metabolism
- Neuronal activity
- Neuronal plasticity
- Mitochondrial protein function
- Mitochondrial protein annotation
- OXPHOS
- Biomarkers
- Aging
- Drug Target
- Drug Repurposing
- Knowledge Base
- Antibodies
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