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Radiation, Oxidative Stress and Damage Related Normal Tissue Complications: Mechanisms and Strategies to Mitigate

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (15 November 2024) | Viewed by 1152

Special Issue Editors


E-Mail Website1 Website2
Guest Editor
1. National Aeronautics and Space Administration (NASA Retired; Research Collaborations LaMont Aerospace and Sovaris Aerospace) Johnson Space Center, Houston, TX 77058, USA
2. Goodwin BioScience Research Institute, Houston, TX 77258, USA
Interests: OSaD; inflammation; regenerative medicine; neural stem cell networks; 3D tissue toxicity; high-energy and galactic cosmic radiation impacts
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department Radiation Oncology, University of California-Irvine, Irvine, CA 92697, USA
Interests: effects of space radiation on the CNS; stem cell and exosome therapies; neuroscience; FLASH radiotherapy; oxidative stress; free radicals

Special Issue Information

Dear Colleagues,

This Special Issue will focus on environmental and endogenous factors and select medical treatments known to elicit a wide range of normal tissue complications through oxidative stress, inflammation and related processes. Manuscripts that focus on the mechanisms responsible for cellular and tissue-level damage responses, as well as interventions to mitigate such damage, will be prioritized. Specific topics of interest include oxidative stress and metabolic stressors, free radical damage and mitigators, space radiation and persistent low-dose effects, stem cell- and exosome-based interventions, epigenetic modifications, and cancer treatment-associated complications and mitigation strategies. Additionally, we welcome submissions that present space radiation-related mitigation strategies derived from authentic space radiation experimentation.

Dr. Thomas J. Goodwin
Prof. Dr. Charles L Limoli
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • free radicals
  • oxidative stress
  • inflammation
  • regenerative medicine
  • effects of space radiation on the CNS
  • stem cell and exosome therapies
  • neuroscience
  • FLASH radiotherapy
  • tissue toxicity
  • high-energy radiation

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Published Papers (1 paper)

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Review

17 pages, 1490 KiB  
Review
Radiation Induced Skin Fibrosis (RISF): Opportunity for Angiotensin II-Dependent Intervention
by Patricia F. Boothe, Vidya P. Kumar, Yali Kong, Kan Wang, Howard Levinson, David Mu and Milton L. Brown
Int. J. Mol. Sci. 2024, 25(15), 8261; https://doi.org/10.3390/ijms25158261 - 29 Jul 2024
Cited by 1 | Viewed by 936
Abstract
Medical procedures, such as radiation therapy, are a vital element in treating many cancers, significantly contributing to improved survival rates. However, a common long-term complication of such exposure is radiation-induced skin fibrosis (RISF), a complex condition that poses substantial physical and psychological challenges. [...] Read more.
Medical procedures, such as radiation therapy, are a vital element in treating many cancers, significantly contributing to improved survival rates. However, a common long-term complication of such exposure is radiation-induced skin fibrosis (RISF), a complex condition that poses substantial physical and psychological challenges. Notably, about 50% of patients undergoing radiation therapy may achieve long-term remission, resulting in a significant number of survivors managing the aftereffects of their treatment. This article delves into the intricate relationship between RISF, reactive oxygen species (ROS), and angiotensin II (Ang II) signaling. It proposes the underlying mechanisms and examines potential treatments for mitigating skin fibrosis. The primary goal is to offer essential insights in order to better care for and improve the quality of life of cancer survivors who face the risk of developing RISF. Full article
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