The Emerging Role of Metal Complex Materials in Pharmaceutical Design and Delivery
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 9508
Special Issue Editor
Interests: nanoscience; nanomedicine; targeted drug delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Recently, metal complex materials have gained research attention in the design and delivery of a variety of pharmaceutical ingredients. Conventional metallic materials, including nanosized metals, used for pharmaceutical applications are usually challenged with high toxicity in addition to poor hydration stability and low solubility and dissolution rates. Coordination complex formation via a combination of chelating agents such as nicotinic acid, pyrazinamide, captopril, guanfacine, etc with transition metals have been explored to address some of the limitations of free metallic materials in pharmaceutical applications. The introduction of a deficient metal ion body, the use of ligands as antidotes to metal-based poisoning, and the pharmacotherapy effect of blocking metal ions required for specific enzymatic activities are some of the benefits of metal complex materials in pharmaceutical applications. However, there still exist several physicochemical challenges that need to be addressed to unlock the full potential of metal complex materials, particularly in relation to the complexity of their synthesis process, biocompatibility, and the level of reduced toxicity. Hence, more research investment is needed to improve the pharmaceutical applications of metal complex materials.
This Special Issue focuses on recent advances in the synthesis, characterization, functionalization, and pharmaceutical applications of metal complex materials. We welcome studies focused on emerging metal complexes, synthesis and characterization apporaches, theoretical simulations, and pharmaceutical applications in drug design and delivery. Both Original Research articles and Reviews can be submitted:
- Synthesis and characterization of novel metal complex materials
- Strategies to enhance the pharmaceutical properties of metal complex materials
- Metal complex-based drug formulations for targeted and controlled delivery
- Advanced smart and functional metal complexes with enhanced drug entrapment efficiency
- Computational approaches to metal complex material formation and analysis
- Functionalization of metal complex materials for pharmaceutical applications
- New pharmaceutical applications of metal complex materials
- Mechanism of action of metal complex materials in pharmaceutical applications
- Toxicity analysis of metal complex materials in pharmaceutical applications
- Large-scale production of metal complex materials for therapeutic applications
Dr. Michael Danquah
Guest Editor
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Keywords
- Metal complexes;
- Pharmaceutical design;
- Crystals;
- Pharmaceutical delivery;
- Transition metals;
- Medicinal chemistry;
- Metal dopants
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