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State-of-the-Art Molecular Pharmacology in France

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 3714

Special Issue Editors


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Collection Editor
Lab of Biomolecules, Sorbonne Universite, Paris, France
Interests: molecular modeling; molecular pharmacology; drug development

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Collection Editor
Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Institut Régional du Cancer de Montpellier, Université de Montpellier, F-34298 Montpellier, France
Interests: drug resistance; chemotherapy; DNA topoisomerases; DNA damage; prostate cancer; colon cancer
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Special Issue Information

Dear Colleagues, 

Pharmacology is a discipline that deals with the interactions between natural, semisynthetic, or fully (bio)synthetic therapeutic agents at the cellular and organismal levels. These therapeutic agents can be small molecules or macromolecules, such as proteins and antibodies. Thus, this subject is positioned at the interface of pharmacy/chemistry and physiology/pathophysiology in their broadest senses. It operates at various organizational levels, such as the molecular, subcellular, cellular, organ, and systemic platforms. Molecular pharmacology investigates the molecular mode of action of therapeutic agents using cellular, genetic, and molecular biology approaches and is among the most rapidly developing fields of pharmacology.

Original research and review articles on molecular pharmacology are invited. The Section “Molecular Pharmacology” aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to study drug action. An additional focus will be on the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level.

A great number of research teams in France from different institutions and universities are working together and devoting considerable effort to developing and studying molecular pharmacology. This Topical Collection is committed to providing an overview of the macromolecular sciences and technologies in France.

Dr. Nicolas Pietrancosta
Prof. Dr. Philippe Pourquier
Collection Editors

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Keywords

  • signal transduction
  • receptor
  • animal models
  • preclinical
  • pharmacodynamics
  • pharmacokinetics
  • drug development
  • drug metabolism

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Published Papers (1 paper)

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Research

25 pages, 3300 KiB  
Article
The Unitary Micro-Immunotherapy Medicine Interferon-γ (4 CH) Displays Similar Immunostimulatory and Immunomodulatory Effects than Those of Biologically Active Human Interferon-γ on Various Cell Types
by Camille Jacques, Mathias Chatelais, Karim Fekir, Adrien Brulefert and Ilaria Floris
Int. J. Mol. Sci. 2022, 23(4), 2314; https://doi.org/10.3390/ijms23042314 - 19 Feb 2022
Cited by 10 | Viewed by 3231
Abstract
As a cytokine, gamma-interferon (IFN-γ) is considered a key player in the fine-tuned orchestration of immune responses. The extreme cellular sensitivity to cytokines is attested by the fact that very few of these bioactive molecules per cell are enough to trigger cellular functions. [...] Read more.
As a cytokine, gamma-interferon (IFN-γ) is considered a key player in the fine-tuned orchestration of immune responses. The extreme cellular sensitivity to cytokines is attested by the fact that very few of these bioactive molecules per cell are enough to trigger cellular functions. These findings can, at least partially, explain how/why homeopathically-prepared cytokines, and especially micro-immunotherapy (MI) medicines, are able to drive cellular responses. We focused our fundamental research on a unitary MI preparation of IFN-γ, specifically employed at 4 CH, manufactured and impregnated onto sucrose-lactose pillules as all other MI medicines. We assessed the IFN-γ concentration in the medium after dilution of the IFN-γ (4 CH)-bearing pillules and we evaluated in vitro drug responses in a wide range of immune cells, and in endothelial cells. Our results showed that IFN-γ (4 CH) stimulated the proliferation, the activation and the phagocytic capabilities of primary immune cells, as well as modulated their cytokine-secretion and immunity-related markers’ expression in a trend that is quite comparable with the well-recognized biological effects induced by IFN-γ. Altogether, these data provide novel and additional evidences on MI medicines, and specifically when active substances are prepared at 4 CH, thus suggesting the need for more investigations. Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Pharmacology in France)
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