New Drugs and Novel Strategies against Nontuberculous Mycobacteria 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 8011
Special Issue Editors
Interests: Mycobacterium tuberculosis
Special Issues, Collections and Topics in MDPI journals
Interests: antitubercular; Mycobacterium tuberculosis; Mycobacterium abscessus; drug resistance
Special Issues, Collections and Topics in MDPI journals
Interests: mycobacteria; tuberculosis; infection diseases; early drug discovery; nontuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium abscessus
Special Issues, Collections and Topics in MDPI journals
Interests: synthesis of new compounds against Mycobacterium tuberculosis and Mycobacterium abscessus
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nontuberculous mycobacteria (NTM) are opportunistic pathogens, causing pulmonary diseases largely in immunocompromised patients or patients with pre-existing lung conditions, such as bronchiectasis, chronic obstructive pulmonary disease, and cystic fibrosis (CF). The NTM incidence (3.3 to 22.6%) is growing in particular among CF patients worldwide. Mycobacterium avium complex (MAC) and Mycobacterium abscessus complex (MABSC) are the most commonly identified NTM species in CF individuals. Among NTM species, Mycobacterium abscessus is becoming the most rapidly emerging pathogen in CF centers around the world.
NTM lung disease treatment is challenging due to the long and often unsuccessful therapy. In FC patients, MABSC infection accelerates lung function decline more than other bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia. CF patients with MABSC are more likely to require transplant or to die despite drug treatment. M. abscessus eradication is further complicated by the spread of drug-resistant strains. Consequently, the discovery of new drugs is vital for CF patients’ life. Increasing research and drug discovery efforts are mandatory to have significant therapeutic advances for NTM diseases.
With this issue, we would like to invite possible contributors that study new drugs and novel strategies against these emerging pathogens to write a research article or review.
Prof. Dr. Maria Rosalia Pasca
Dr. Laurent Chiarelli
Dr. Giulia Degiacomi
Dr. Vadim Makarov
Guest Editors
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Keywords
- nontuberculous Mycobacteria
- Mycobacterium abscessus
- lung diseases
- cystic fibrosis
- new drugs
- cellular targets
- drug resistance
- mechanism of action of new drugs
- emerging bacterial pathogens
- therapy
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