Old and New Mechanisms of Microbial Drug Resistance
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (29 May 2023) | Viewed by 3786
Special Issue Editors
Interests: Mycobacterium tuberculosis
Special Issues, Collections and Topics in MDPI journals
Interests: mycobacteria; tuberculosis; infection diseases; early drug discovery; nontuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium abscessus
Special Issues, Collections and Topics in MDPI journals
Interests: antitubercular; Mycobacterium tuberculosis; Mycobacterium abscessus; drug resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In 2017, WHO declared the critical need for research for new antibiotics to fight microbial drug resistance. In addition, WHO recently highlighted that the rise of antimicrobial resistance has been reinforced by the inappropriate use of antibiotics during the COVID-19 pandemic. Thus, international action plans for fighting antimicrobial resistance should be mandatory in the post-COVID-19 era.
Worldwide, more than a million people die each year from infections that do not respond to drugs, and scientists estimate that annual deaths will exceed 10 million by 2050.
According to a Centers for Disease Control and Prevention (USA) report, infections caused by drug-resistant microorganisms increased by 15% during the first year of the pandemic. In particular, some nosocomial pathogens are on the rise in intensive care and are of great concern to health authorities; these include antibiotic-resistant Acinetobacter baumannii (increased by 78%) and the fungus Candida auris (increased by 60%). Bacteria, like viruses, develop mutations that are then selected by the environment; if the environment is full of antibiotics, the mutations that make the bacteria resistant to them will be favored.
Therefore, the study and the better understanding of the mechanisms related to microbial drug resistance could help us to look for novel strategies to surpass this problem.
Prof. Dr. Maria Rosalia Pasca
Dr. Giulia Degiacomi
Dr. Chiarelli Laurent
Guest Editors
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Keywords
- multidrug resistance
- new drugs
- bacterial pathogens
- mycobacteria
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