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Gene Expression and Molecular Targets of Oral Cancer and Periodontal...
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Gene Expression and Molecular Targets of Oral Cancer and Periodontal Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (15 June 2022) | Viewed by 20675

Special Issue Editor

Dr. Fuyuki Sato

E-Mail Website
Guest Editor
Department of Diagnostic Pathology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka Prefecture 411-8777, Japan
Interests: crosstalk between circadian rhythm and tumor progression; pathological analysis in human and mouse tissues; functional analysis of DEC1 and DEC2 in tumor progression; molecular pathways of DEC1 and DEC2; crosstalk between basic and clinical research, involving clock genes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent evidence has shown that molecular targets in various cancers are very important. Abnormalities of p53 and cyclinD1 may play important roles in the tumor progression of oral cancer. However, the molecular targets in oral cancer have not been well understood. Therefore, we strongly encourage understanding the molecular target of oral cancer. We could supply new molecular therapy and chemothepy in the future. Furthermore, oral diseases such as periodontal diseases and ameloblastoma are welcome. Severe inflammation for long periods may promote oral cancer. We widely accept studies on oral lesion, involving gene expression and molecular targets.

Topics include, but are not limited to the following: Molecular pathways/target of oral cancer and diseases.

Dr. Fuyuki Sato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral cancer
  • squamous cell carcinoma
  • periodontal disease
  • molecular target
  • gene expression

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Published Papers (3 papers)

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Review

31 pages, 9778 KiB  
Review
Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses
by Miguel Ángel González-Moles, Carmen Keim-del Pino and Pablo Ramos-García
Int. J. Mol. Sci. 2022, 23(21), 13099; https://doi.org/10.3390/ijms232113099 - 28 Oct 2022
Cited by 10 | Viewed by 11671
Abstract
Oral lichen planus (OLP) is a common chronic inflammatory disease of unknown etiology and likely autoimmune nature that is currently considered an oral potentially malignant disorder, implying that patients suffering from this process are at risk of developing oral cancer in their lifetime. [...] Read more.
Oral lichen planus (OLP) is a common chronic inflammatory disease of unknown etiology and likely autoimmune nature that is currently considered an oral potentially malignant disorder, implying that patients suffering from this process are at risk of developing oral cancer in their lifetime. The molecular alterations that develop in OLP and that make the affected oral epithelium predisposed to malignancy are unknown, although, as in other autoimmune diseases (ulcerative colitis, primary biliary cirrhosis, etc.), they may be linked to oncogenesis-promoting effects mediated by the inflammatory infiltrate. So far there is no in-depth knowledge on how these hallmarks of cancer are established in the cells of the oral epithelium affected by OLP. In this scoping review of systematic reviews and meta-analyses the state of evidence based knowledge in this field is presented, to point out gaps of evidence and to indicate future lines of research. MEDLINE, Embase, Cochrane Library and Dare were searched for secondary-level studies published before October 2022. The results identified 20 systematic reviews and meta-analyses critically appraising the hallmarks tumor-promoting inflammation (n = 17, 85%), sustaining proliferative signaling (n = 2, 10%), and evading growth suppressors (n = 1, 5%). No evidence was found for the other hallmarks of cancer in OLP. In conclusion, OLP malignization hypothetically derives from the aggressions of the inflammatory infiltrate and a particular type of epithelial response based on increased epithelial proliferation, evasion of growth-suppressive signals and lack of apoptosis. Future evidence-based research is required to support this hypothesis. Full article
(This article belongs to the Special Issue Gene Expression and Molecular Targets of Oral Cancer and Periodontal Diseases)
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15 pages, 1240 KiB  
Review
Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues
by Xingzhi Wang, Nitesh Tewari, Fuyuki Sato, Keiji Tanimoto, Lakshmi Thangavelu, Makoto Makishima and Ujjal K. Bhawal
Int. J. Mol. Sci. 2022, 23(2), 962; https://doi.org/10.3390/ijms23020962 - 16 Jan 2022
Cited by 10 | Viewed by 4309
Abstract
Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help to optimize its use in clinical applications. [...] Read more.
Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help to optimize its use in clinical applications. Studies of NaF and epithelial cells, osteoblasts, osteoclasts, and periodontal cells have suggested the significant roles of fluoride treatment. In this review, we summarize recent studies on the biphasic functions of NaF that are related to both soft and hard periodontal tissues, multiple diseases, and clinical dentistry. Full article
(This article belongs to the Special Issue Gene Expression and Molecular Targets of Oral Cancer and Periodontal Diseases)
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Figure 1

11 pages, 747 KiB  
Review
The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation
by Xingzhi Wang, Fuyuki Sato, Keiji Tanimoto, Niveda Rajeshwaran, Lakshmi Thangavelu, Makoto Makishima and Ujjal K. Bhawal
Int. J. Mol. Sci. 2021, 22(19), 10349; https://doi.org/10.3390/ijms221910349 - 26 Sep 2021
Cited by 10 | Viewed by 3937
Abstract
Periodontal inflammation is a common inflammatory disease associated with chronic inflammation that can ultimately lead to alveolar attachment loss and bone destruction. Understanding autophagy and pyroptosis has suggested their significant roles in inflammation. In recent years, studies of differentiated embryo-chondrocyte expressed genes 1 [...] Read more.
Periodontal inflammation is a common inflammatory disease associated with chronic inflammation that can ultimately lead to alveolar attachment loss and bone destruction. Understanding autophagy and pyroptosis has suggested their significant roles in inflammation. In recent years, studies of differentiated embryo-chondrocyte expressed genes 1 and 2 (Dec1 and Dec2) have shown that they play important functions in autophagy and in pyroptosis, which contribute to the onset of periodontal inflammation. In this review, we summarize recent studies on the roles of clock genes, including Dec1 and Dec2, that are related to periodontal inflammation and other diseases. Full article
(This article belongs to the Special Issue Gene Expression and Molecular Targets of Oral Cancer and Periodontal Diseases)
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