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Fish Immunology, 5th Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 612

Special Issue Editors


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Guest Editor

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Guest Editor
Centro Oceanográfico de Murcia (COMU-IEO), CSIC, Carretera de la Azohía s/n, Puerto de Mazarrón, 30860 Murcia, Spain
Interests: immune-reproductive responses; marine fish; viral transmission through the gonad; endocrine disruption
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Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue on “Fish Immunology: 4th Edition”. (https://www.mdpi.com/journal/ijms/special_issues/71VBK8520G).

A Special Issue on the topic of “Fish Immunology” is being launched by the International Journal of Molecular Sciences. Fish represent a fascinating research model in immunology, because they were the first group during animal evolution to have a complete and functional immune system comprising a diverse and interconnected array of both innate and acquired immune tissues, cells, and molecules. Apart from this, the spectacular growth of aquaculture production for human nutrition has attracted the focus of many researchers all over the world for practical and applied purposes. In addition, the implementation of zebrafish as a biomedicine model is extending the range of interests and potential of fish biology, including immunology. This Special Issue aims to gather new research and applied topics in the field of fish immunology at the molecular level, including but not limited to issues relating to immunoglobulins, toll-like receptors, chemokines, interferons, lectins, acute-phase proteins, interleukins, antimicrobial peptides, and inflammation, as well as leucocyte types, distribution and trafficking, maturation and molecular markers, vaccines, response to pathogens, immune regulation, evolution, and so on. Reviews or research articles in this fascinating area, which discuss the benefits of using fish as models of study and their applications or which aim to discern the bottlenecks in the field, are welcome.

Dr. Alberto Cuesta
Dr. Elena Chaves-Pozo
Guest Editors

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Keywords

  • fish immunology
  • innate immunity
  • acquired immunity
  • leucocytes
  • disease
  • immunostimulants
  • immunodepression
  • inflammation

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Published Papers (1 paper)

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Research

25 pages, 6608 KiB  
Article
Microbiome–Metabolomics Analysis Insight into the Effects of Starvation and Refeeding on Intestinal Integrity in the Juvenile Largemouth Bass (Micropterus salmoides)
by Zhenxin Zhao, Xianbo Zhang, Fei Zhao and Tianxun Luo
Int. J. Mol. Sci. 2024, 25(23), 12500; https://doi.org/10.3390/ijms252312500 - 21 Nov 2024
Viewed by 325
Abstract
The effects of starvation and refeeding on the gut condition of juvenile largemouth bass (Micropterus salmoides) remain unclear. Therefore, our research aimed to explore these effects. Amylase and lipase activities were remarkably decreased in the starvation (ST) group, yet prominently increased [...] Read more.
The effects of starvation and refeeding on the gut condition of juvenile largemouth bass (Micropterus salmoides) remain unclear. Therefore, our research aimed to explore these effects. Amylase and lipase activities were remarkably decreased in the starvation (ST) group, yet prominently increased in the refeeding (RE) group (p < 0.05). In addition to the malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities were significantly upregulated in the ST group (p < 0.05) in marked contrast to those in the controls; however, the RE group showed no substantial variations in CAT and SOD activities or the MDA level (p > 0.05). During starvation, the expression of Nrf2-Keap1 pathway-associated genes was significantly upregulated (p < 0.05). The comparative levels of TNF-α, IL-1β, and IL-15 were highly increased, with the levels of TGF-β1 and IL-10 apparently downregulated in the ST group; in contrast, these levels were restored to their original values in the RE group (p < 0.05). In contrast to the controls, the ST group showed significantly lower height and width of the villi, muscle thickness, and crypt depth and a higher goblet cell number; however, these values were recovered to some extent in the RE group (p < 0.05). The dominant bacterial phyla in the intestines of both groups were Proteobacteria, Firmicutes, Bacteroidetes, Acidobacteria, and Actinobacteria, with marked inter-group differences in the genera Serratia and Lactobacillus. Metabolomics analysis showed that amino acid metabolism is disrupted during starvation and is restored after refeeding. In summary, this study expands our comprehension of the interaction between oxidative stress and antioxidant defenses among juvenile largemouth bass subjected to starvation and refeeding. Full article
(This article belongs to the Special Issue Fish Immunology, 5th Edition)
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