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IJMS
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Lymphatic Disorders: From Molecular Mechanisms to Therapies
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Lymphatic Disorders: From Molecular Mechanisms to Therapies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 2802

Special Issue Editor

Dr. Laura Patton

E-Mail Website
Guest Editor
Endocrinology and Lymphology Clinic, 38096 Vallelaghi, Italy
Interests: endocrinology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues，

In the current healthcare panorama, lymphology is increasingly establishing itself as a discipline with numerous applications in every field of medicine; despite this, even today, with the continuous progress of science, it remains the prerogative of only a few specialists to the detriment of thousands of patients who suffer and often wait years before receiving a diagnosis and starting therapy.

This Special Issue of the International Journal of Molecular Sciences will focus on underlining the importance of the lymphatic system and its related diseases in all of its molecular declinations and clinical implications, and how these impact daily healthcare activities.

It is therefore hoped that this idea will push researchers and doctors who deal with this discipline to share their experiences and shed light on the countless twists and turns of a multidimensional labyrinth such as lymphology.

Since IJMS is a journal of molecular science, pure clinical studies will not suitable for our journal; however, clinical or pure model submissions with biomolecular experiments are welcomed. 

Dr. Laura Patton
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lymphoedema
  • lipedema
  • matrix
  • vascular disorder
  • ultrasound
  • lacteal
  • microbiota
  • intersitial fluid

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Published Papers (3 papers)

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Research

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11 pages, 4108 KiB  
Article
Ultrasound Irradiation as a Candidate Procedure to Improve the Transdermal Drug Delivery to the Tail Edema of a Mouse Model
by Shinji Kumegawa, Takuya Suzuki, Kota Fujimoto, Kazuhisa Uemura, Katsuro Tachibana, Gen Yamada and Shinichi Asamura
Int. J. Mol. Sci. 2024, 25(22), 11883; https://doi.org/10.3390/ijms252211883 - 5 Nov 2024
Viewed by 461
Abstract
Drug therapy for secondary lymphedema has not yet been established. Conventional oral and intravenous administration is difficult to administer in sufficient doses due to adverse events. Therefore, it is necessary to develop a transdermal delivery system that can deliver high concentrations of drugs [...] Read more.
Drug therapy for secondary lymphedema has not yet been established. Conventional oral and intravenous administration is difficult to administer in sufficient doses due to adverse events. Therefore, it is necessary to develop a transdermal delivery system that can deliver high concentrations of drugs to the edema area. In this study, we examined the efficacy of transdermal drug delivery in a mouse model of tail edema using ultrasound irradiation (sonication method). Ultrasound irradiation can deliver high-molecular-weight substances subcutaneously, and the percutaneous administration of clobetasol propionate to the mouse tail edema model prevented the enlargement of lymphatic vessels with reduced tail volume. Therefore, steroid administration utilizing ultrasound irradiation is effective in decreasing tail swelling in a mouse tail edema model. Thus, ultrasound irradiation could have the potential to innovate the treatment of secondary lymphedema by directly administering the drug to the edema. Full article
(This article belongs to the Special Issue Lymphatic Disorders: From Molecular Mechanisms to Therapies)
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16 pages, 2328 KiB  
Article
A Comprehensive Investigation of Stimulatory Agents on MAIT and Vα7.2+/CD161− T Cell Response and Effects of Immunomodulatory Drugs
by Parvind Singh, Marianna Száraz-Széles, Sándor Baráth and Zsuzsanna Hevessy
Int. J. Mol. Sci. 2024, 25(11), 5895; https://doi.org/10.3390/ijms25115895 - 28 May 2024
Viewed by 1053
Abstract
Mucosal-associated invariant T (MAIT) cells, a subset of Vα7.2+ T cells, are a crucial link between innate and adaptive immunity, responding to various stimuli through TCR-dependent and independent pathways. We investigated the responses of MAIT cells and Vα7.2+/CD161− T cells to different stimuli [...] Read more.
Mucosal-associated invariant T (MAIT) cells, a subset of Vα7.2+ T cells, are a crucial link between innate and adaptive immunity, responding to various stimuli through TCR-dependent and independent pathways. We investigated the responses of MAIT cells and Vα7.2+/CD161− T cells to different stimuli and evaluated the effects of Cyclosporin A (CsA) and Vitamin D3 (VitD). Peripheral blood mononuclear cells (PBMCs) from healthy donors were stimulated with various agents (PMA/Ionomycin, 5-OP-RU, 5-OP-RU/IL-12/IL-33) with or without CsA and VitD. Flow cytometric analysis assessed surface markers and intracellular cytokine production. Under steady-state conditions, MAIT cells displayed elevated expression of CCR6 and IL-13. They showed upregulated activation and exhaustion markers after activation, producing IFNγ, TNFα, and TNFα/GzB. CsA significantly inhibited MAIT cell activation and cytokine production. Conversely, Vα7.2+/CD161− T cells exhibited distinct responses, showing negligible responses to 5-OP-RU ligand but increased cytokine production upon PMA stimulation. Our study underscores the distinct nature of MAIT cells compared to Vα7.2+/CD161− T cells, which resemble conventional T cells. CsA emerges as a potent immunosuppressive agent, inhibiting proinflammatory cytokine production in MAIT cells. At the same time, VitD supports MAIT cell activation and IL-13 production, shedding light on potential therapeutic avenues for immune modulation. Full article
(This article belongs to the Special Issue Lymphatic Disorders: From Molecular Mechanisms to Therapies)
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Review

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13 pages, 1137 KiB  
Review
Disease-Specific Alteration of Cardiac Lymphatics: A Review from Animal Disease Models to Clinics
by Yuuki Shimizu, Haihang Luo and Toyoaki Murohara
Int. J. Mol. Sci. 2024, 25(19), 10656; https://doi.org/10.3390/ijms251910656 - 3 Oct 2024
Viewed by 719
Abstract
For many years, the significance of cardiac lymphatic vessels was largely overlooked in clinical practice, with little consideration given to their role in the pathophysiology or treatment of cardiac diseases. However, recent research has brought renewed attention to these vessels, progressively illuminating their [...] Read more.
For many years, the significance of cardiac lymphatic vessels was largely overlooked in clinical practice, with little consideration given to their role in the pathophysiology or treatment of cardiac diseases. However, recent research has brought renewed attention to these vessels, progressively illuminating their function and importance within the realm of cardiovascular science. Experimental studies, particularly those utilizing animal models of cardiac disease, have demonstrated a clear relationship between cardiac lymphatic vessels and both the pathogenesis and progression of these conditions. These findings have prompted a growing interest in potential therapeutic applications that specifically target the cardiac lymphatic system. Conversely, while clinical investigations into cardiac lymphatics remain limited, recent studies have begun to explore their identification through specific surface markers, as well as the expression dynamics of lymphangiogenic factors. These studies have increasingly highlighted associations of lymphatic dysfunction with inflammation and fibrosis, both of which negatively impact cardiac function and remodeling across various pathological states. Despite these advances, comprehensive reviews of the current knowledge regarding the cardiac lymphatic vasculature, particularly within specific disease contexts, remain scarce. This review aims to address this gap by providing a detailed synthesis of existing reports, encompassing both animal model research and studies on human clinical specimens, with a special focus on the role of cardiac lymphatic vessels in different disease states. Full article
(This article belongs to the Special Issue Lymphatic Disorders: From Molecular Mechanisms to Therapies)
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