Thrombo-Inflammatory Signaling and Complications in Autoimmune Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 May 2025 | Viewed by 3
Special Issue Editor
Interests: inflammation; thrombosis; chronic disorders; anti-inflammatory bioactives; antioxidants
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Thrombo-inflammation and thrombus formation are critical responses within the host to sustain hemostasis during trauma and obstruct the spread of invasive pathogens in the bloodstream. This physiological response ingeniously integrates immune system activation with procoagulant pathways involving multiple vascular cell types, illustrating a sophisticated defense mechanism. However, despite its protective functions, the excessive activation of the underlying pro-inflammatory and pro-thrombotic mechanisms can unfavorably further induce several pathogenicity processes and thrombo-inflammatory complications, where exacerbated coagulation and cell activation triggers and amplifies various inflammatory disease states, including several autoimmune disorders. Vice versa, the disease state of several autoimmune disorders involves a continuous inflammatory risk that can trigger excessive pro-inflammatory and pro-thrombotic mechanistic responses linked to thrombo-inflammatory complications that exacerbate the associated pathological manifestations and the associated risk for unbalancing the disease state in these diseases.
This Special Issue aims to dissect the dualistic nature of thrombo-inflammatory signaling in autoimmune disorders, assessing both its involvement in the triggering and/or its contributions to pathological states of several autoimmune disorders, as well as its favorable/unfavorable interaction with the well-established mitigation strategies and therapeutic approaches applied in these disorders in the clinical setting.
Therefore, we welcome the submission of research articles, reviews (comprehensive, critical, opinion, or systematic ones), and meta-analyses addressing, but not limited to, the multifaceted roles of thrombo-inflammatory signaling in autoimmune disorders, which will provide further insights into understanding the molecular mechanisms and signaling cues involved in thrombo-inflammatory complications and the disease state across a spectrum of autoimmune diseases, as well as the clinical impacts of dysregulated thrombo-inflammatory processes, along with their interactions with mitigation strategies for each type of autoimmune disorder and several proposed novel therapeutic targets and preventative approaches against thrombo-inflammation that can prevent and/or improve the disease state and patients’ outcomes in such autoimmune disorders.
This Special Issue encourages the exploration of emerging, non-traditional roles of thrombo-inflammation, delving into how its modulation can influence disease progression and therapy in autoimmune disorders.
Dr. Alexandros Tsoupras
Guest Editor
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Keywords
- inflammation
- thrombosis
- platelets
- coagulation
- autoimmune disorders
- rheumatoid arthritis
- systematic erythematosus lupus
- antiphospholipid syndrome
- thrombo-inflammation
- antithrombotic
- antiplatelet
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