Marine Bioactives for Functional Cosmetics with Health-Promoting Properties

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 790

Special Issue Editor


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Hephaestus Laboratory, Department of Chemistry, School of Science, Democritus University of Thrace, Kavala University Campus, St Lucas, GR 65404 Kavala, Greece
Interests: inflammation; thrombosis; oxidative stress; chronic disorders; cardiovascular disoases; cancer; renal disorders; neurodegenerative disorders; persistent infections; anti-inflammatory; antithrombotic; antioxidant; cardio-protective; antitumor; antidiabetic; skin protection; anti-ageing; anti-UV protection; natural bioactives; bioactives; bioactive compounds; bioactive ingredients; valorization of by-products; phenolics; polar lipids; vitamins; functional foods; supplements; nutraceuticals; drugs; cosmetics
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Special Issue Information

Dear Colleagues,

Inflammation, photo-degradation, oxidative stress, and ageing are common features of several skin complications. Several cosmetics, nutricosmetics, cosmeceuticals ,and sunscreens/sun-oils have been proposed to provide anti-inflammatory, photo-protective, antioxidant, anti-melanoma, and anti-ageing skin protection, including products that contain natural bioactives with skin-health-promoting effects.

The objective of this Special Issue is to promote research in the field that will outline the current status and future perspectives on the valorization of marine bioactives from sustainable marine sources (including marine bioactives from fish species, mollusks, seaweeds, macro-/micro-algae, fungi, and several other marine microorganisms) and marine by-products, to highlight their importance as ingredients for the design and production of high-value, bio-functional cosmetics’ products, including nutricosmetics, cosmeceuticals, sunscreens/sun-oils, and pharmaceutical cosmetics with promising anti-inflammatory, photo-protective, antioxidant, anti-melanoma, and anti-ageing skin-health-promoting effects.

Emphasis will be given to research with state-of-the-art methods of isolation and molecular analysis applied to several sustainable marine sources for obtaining/extracting and fractionating such marine micro-/macro- bioactives from prime extracts/mixtures/filtrates/isolates/hydrolysates/etc. derived from a sustainable marine source. We also welcome research on OMICS-based full chemical characterization and structural elucidation, in tandem with designed and tailored bioassays and in vitro/ex vivo/in vivo approaches, to evaluate the structure–activity relationship and potential synergism(s) against specific bio-molecular pathways and cell/tissue biological responses for skin health. Such experimental design and derived data are of paramount importance to assess structure–activity and causality, which will provide molecular evidence for the utilization of the most optimum bio-functional marine bioactives or their mixtures to produce targeted bio-functional cosmetics with skin-health-promoting effects, based also on current legislations and according to the needs of the industry and consumers.

Studies containing such targeted biomolecular experiments accompanied by appropriately designed approaches for evaluating the clinical safety and efficacy of cosmetics containing such marine bioactives, through tandem animal studies, ex vitro studies in animal tissues, and trials, are also welcomed. Special attention will be given to studies on such sustainable marine bioactives with higher safety, efficacy, and bioavailability in the skin for skin protection.

Finally, relatively comprehensive reviews, systematic reviews, and meta-analysis articles in the field are also welcomed in this Special Issue.

Dr. Alexandros Tsoupras
Guest Editor

Manuscript Submission Information

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Keywords

  • skin inflammation
  • photo-oxidation
  • ageing
  • sustainable marine sources
  • marine bioactives
  • structure–activity relationship
  • synergism
  • skin health
  • skin protection
  • bio-functional
  • functional products
  • cosmetics
  • nutricosmetics
  • cosmeceuticals
  • pharmaceutical cosmetics
  • pharmaceutical ointments
  • sunscreen
  • sun oils
  • photo-protection
  • anti-inflammatory
  • anti-ageing
  • antioxidant
  • anti-melanoma
  • skin protection
  • fish
  • mollusks
  • macro-algae
  • micro-algae
  • seaweed
  • marine fungi
  • marine microorganisms
  • marine by-products

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Published Papers (1 paper)

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Research

15 pages, 3337 KiB  
Article
Moisturizing Effects of Alcalase Hydrolysate Fractions from Haliotis discus Viscera, a Marine Organism, on Human Dermal Fibroblasts, HaCaT Keratinocytes, and Reconstructed Human Skin Tissues
by Nalae Kang, Eun-A Kim, Seong-Yeong Heo, Jun-Ho Heo, Ginnae Ahn and Soo-Jin Heo
Mar. Drugs 2024, 22(11), 503; https://doi.org/10.3390/md22110503 - 6 Nov 2024
Viewed by 526
Abstract
Haliotis discus, an abalone, is a marine gastropod mollusk that has been cultivated globally owing to its nutritional value and high market demand. However, the visceral parts of H. discus are typically discarded as by-products, highlighting the need to explore their potential [...] Read more.
Haliotis discus, an abalone, is a marine gastropod mollusk that has been cultivated globally owing to its nutritional value and high market demand. However, the visceral parts of H. discus are typically discarded as by-products, highlighting the need to explore their potential value in developing cosmeceuticals and pharmaceuticals. This study investigated the potential moisturizing effects of H. discus visceral tissues. Various hydrolysates from H. discus viscera tissue were evaluated for proximate composition, radical scavenging, and hyaluronidase inhibition activities. Alcalase hydrolysate was isolated using gel filtration chromatography (GFC), and its moisturizing effects were tested on human dermal fibroblasts (HDF), HaCaT keratinocytes, and reconstructed human skin tissue. The Alcalase hydrolysate showed the highest extraction yield, radical scavenging, and hyaluronidase inhibition activities. The Alcalase hydrolysate GFC fraction 1 increased collagen synthesis-related molecules, including procollagen type 1 in HDF and hyaluronic acid-related molecules in HaCaT cells. These moisturizing effects were confirmed in reconstructed human skin tissues by increased levels of aquaporin 3 and filaggrin. Fraction 1 consisted of two main peptides: DNPLLPGPPF and SADNPLLPGPPF. In conclusion, H. discus Alcalase hydrolysate and its fractions have potential moisturizing properties and can be used as cosmeceuticals. Full article
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