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Molecular Advances in Bioelectrochemistry
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Molecular Advances in Bioelectrochemistry

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 3329

Special Issue Editors

Dr. Ana Dora Rodrigues Pontinha

E-Mail Website
Guest Editor
1. University of Coimbra, ISISE, ARISE, Department of Civil Engineering, Rua Luís Reis Santos, 3030-788 Coimbra, Portugal
2. SeaPower, Associação para o desenvolvimento da Economia do Mar, Rua Das Acácias, Nº 40A, Parque Industrial Da Figueira Da Foz, 3090-380 Figueira Da Foz, Portugal
Interests: bioelectrochemistry; redox flow batteries; aerogel; biomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Beatriz Merillas

E-Mail Website
Guest Editor
Cellular Materials Laboratory (CellMat), Department of Condensed Material Physics, Facultad de Ciencias, University of Valladolid, 47011 Valladolid, Spain
Interests: aerogels; thermal insulation; foams; porous materials; biopolymers; polyurethane
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to the topic of “Molecular Advances in Bioelectrochemistry”.

The following Special Issue aims to highlight the new interactions between biological systems and electrodes; this involves the study of electron transfer processes in biological molecules, which has applications in various fields such as energy conversion, biosensors, and biofuel cells. Molecular advances in bioelectrochemistry encompass a wide range of research areas, including the development of novel materials, our understanding of electron transfer mechanisms, and exploring applications in biotechnology. The molecular advances in bioelectrochemistry contribute to the development of innovative technologies with applications in energy storage, sensing, and biomedical devices.

Leading by Dr. Ana Dora Rodrigues Pontinha and assisting by our Topical Advisory Panel Member, Dr. Beatriz Merillas (University of Valladolid, Spain), this Special Issue will focus on review articles, original research articles, and short communications, addressing all aspects of the bioelectrochemistry field, with a highly interdisciplinary scope, from electrosynthesis and contemporary energy challenges to mechanistic investigations underlying biological redox processes. This Special Issue welcomes contributions addressing, but not limited to, the following topics: electron transfer in biological systems, bioelectrochemical sensors and biosensors, electroactive biomolecules, nanomaterials in bioelectrochemistry, enzyme engineering for biofuel cells, redox-active polymers, and molecular dynamics and simulation studies for bioelectrochemistry reactions.

Dr. Ana Dora Rodrigues Pontinha
Dr. Beatriz Merillas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioelectrochemical devices
  • molecular bioelectrochemistry
  • bioelectrochemical sensors
  • DNA sensors
  • protein sensors
  • detection of proteins and DNA
  • cancer
  • human disease
  • electrode surface
  • electrochemical biointerfaces

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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18 pages, 12113 KiB  
Article
Screen-Printed Electrodes—A Promising Tool for Antineoplastic Drug Detection (Cisplatin and Bleomycin) in Biological Samples
by Andreea-Cristina Mirica (Ion), Dana Stan, Dragos-Cosmin Zaharia, Horia Iovu, Sorin Mocanu, Marioara Avram and Lorena-Andreea Bocancia-Mateescu
Int. J. Mol. Sci. 2024, 25(15), 8030; https://doi.org/10.3390/ijms25158030 - 23 Jul 2024
Viewed by 703
Abstract
Cancer remains one of the leading causes for death worldwide. Palliative chemotherapy is vital for certain cancer patients, highlighting the critical need for treatment monitoring tools to prevent drug accumulation and mitigate the risk of high toxicity. Therefore, our aim was to evaluate [...] Read more.
Cancer remains one of the leading causes for death worldwide. Palliative chemotherapy is vital for certain cancer patients, highlighting the critical need for treatment monitoring tools to prevent drug accumulation and mitigate the risk of high toxicity. Therefore, our aim was to evaluate the potential of screen-printed electrodes for the development of sensitive and accurate biosensors for the detection/quantification of antineoplastic drugs. To this purpose, we developed a cisplatin sensor. By functionalizing the gold electrode with human serum albumin and by collecting the electrochemical signal obtained in a H2O2 solution, through voltammetry measurements, we were able to correlate the current measured at 430 mV with the concentration of cisplatin present in human serum samples, with a correlation coefficient of R2 = 0.99. Also, a bleomycin biosensor was developed and proven functional, but further optimization steps were employed in order to improve the accuracy. The developed biosensors have a detection range of 0.0006–43.2 mg/mL for cisplatin and 0.23–7.56 μg/mL for bleomycin in the serum samples. Our preliminary results show that these biosensors can facilitate the real-time monitoring of cisplatin and bleomycin serum levels, allowing healthcare professionals to tailor treatment strategies based on individual patient responses. Full article
(This article belongs to the Special Issue Molecular Advances in Bioelectrochemistry)
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Review

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31 pages, 6119 KiB  
Review
Trends on Aerogel-Based Biosensors for Medical Applications: An Overview
by Cláudio M. R. Almeida, Beatriz Merillas and Ana Dora Rodrigues Pontinha
Int. J. Mol. Sci. 2024, 25(2), 1309; https://doi.org/10.3390/ijms25021309 - 21 Jan 2024
Cited by 2 | Viewed by 2108
Abstract
Aerogels are unique solid-state materials composed of interconnected 3D solid networks and a large number of air-filled pores. This structure leads to extended structural characteristics as well as physicochemical properties of the nanoscale building blocks to macroscale, and integrated typical features of aerogels, [...] Read more.
Aerogels are unique solid-state materials composed of interconnected 3D solid networks and a large number of air-filled pores. This structure leads to extended structural characteristics as well as physicochemical properties of the nanoscale building blocks to macroscale, and integrated typical features of aerogels, such as high porosity, large surface area, and low density, with specific properties of the various constituents. Due to their combination of excellent properties, aerogels attract much interest in various applications, ranging from medicine to construction. In recent decades, their potential was exploited in many aerogels’ materials, either organic, inorganic or hybrid. Considerable research efforts in recent years have been devoted to the development of aerogel-based biosensors and encouraging accomplishments have been achieved. In this work, recent (2018–2023) and ground-breaking advances in the preparation, classification, and physicochemical properties of aerogels and their sensing applications are presented. Different types of biosensors in which aerogels play a fundamental role are being explored and are collected in this manuscript. Moreover, the current challenges and some perspectives for the development of high-performance aerogel-based biosensors are summarized. Full article
(This article belongs to the Special Issue Molecular Advances in Bioelectrochemistry)
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