ijms-logo

Journal Browser

Journal Browser

Brain Plasticity in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2914

Special Issue Editor


E-Mail Website
Guest Editor
1. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
2. Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Iraq
Interests: physiology; ion channels; electrophysiology; neurophysiology; cerebellum; schizophrenia; public health; molecular biology; cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The brain structure and function are continuously remodeled by plasticity, a process that confers the brain the remarkable ability to adapt and rewire during neurodevelopment, in adulthood and following pathological damage. Plasticity manifests at different scales, from synapses to microcircuits and large-scale networks. It actively shapes learning and memory, contributes to brain development and ensures the maintenance of neural homeostasis. In this Special Issue, we delve into the plastic processes, shedding light on how it evolves in physiological and pathological conditions. The Special Issue integrates observations spanning the molecular, cellular and system levels, and covers the latest research in neurophysiology, neuroimaging and computational modeling. We cordially invite you to participate in this Special Issue by presenting your most recent research on this topic. We welcome experimental papers, up-to-date review articles and commentaries.

Dr. Pawan Faris
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain plasticity
  • brain structure and function
  • cerebral cortex, cerebellum
  • neurological disorders
  • neuropsychiatric disorders
  • neurophysiology
  • computational modeling
  • brain imaging
  • Neuroplasticity

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

25 pages, 5920 KiB  
Article
Morphological Signatures of Neurogenesis and Neuronal Migration in Hypothalamic Vasopressinergic Magnocellular Nuclei of the Adult Rat
by Limei Zhang, Mario A. Zetter, Vito S. Hernández, Oscar R. Hernández-Pérez, Fernando Jáuregui-Huerta, Quirin Krabichler and Valery Grinevich
Int. J. Mol. Sci. 2024, 25(13), 6988; https://doi.org/10.3390/ijms25136988 - 26 Jun 2024
Cited by 1 | Viewed by 1452
Abstract
The arginine vasopressin (AVP)-magnocellular neurosecretory system (AVPMNS) in the hypothalamus plays a critical role in homeostatic regulation as well as in allostatic motivational behaviors. However, it remains unclear whether adult neurogenesis exists in the AVPMNS. By using immunoreaction against AVP, neurophysin II, glial [...] Read more.
The arginine vasopressin (AVP)-magnocellular neurosecretory system (AVPMNS) in the hypothalamus plays a critical role in homeostatic regulation as well as in allostatic motivational behaviors. However, it remains unclear whether adult neurogenesis exists in the AVPMNS. By using immunoreaction against AVP, neurophysin II, glial fibrillar acidic protein (GFAP), cell division marker (Ki67), migrating neuroblast markers (doublecortin, DCX), microglial marker (Ionized calcium binding adaptor molecule 1, Iba1), and 5′-bromo-2′-deoxyuridine (BrdU), we report morphological evidence that low-rate neurogenesis and migration occur in adult AVPMNS in the rat hypothalamus. Tangential AVP/GFAP migration routes and AVP/DCX neuronal chains as well as ascending AVP axonal scaffolds were observed. Chronic water deprivation significantly increased the BrdU+ nuclei within both the supraaoptic (SON) and paraventricular (PVN) nuclei. These findings raise new questions about AVPMNS’s potential hormonal role for brain physiological adaptation across the lifespan, with possible involvement in coping with homeostatic adversities. Full article
(This article belongs to the Special Issue Brain Plasticity in Health and Disease)
Show Figures

Figure 1

Review

Jump to: Research

16 pages, 1028 KiB  
Review
Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Schizophrenia and Bipolar Disorder: A Systematic Review
by Andrés Liberona, Natalia Jones, Karen Zúñiga, Verónica Garrido, Mario Ignacio Zelada, Hernán Silva and Rodrigo R. Nieto
Int. J. Mol. Sci. 2024, 25(20), 11204; https://doi.org/10.3390/ijms252011204 - 18 Oct 2024
Viewed by 892
Abstract
Brain-derived neurotrophic factor (BDNF) is a potential biomarker of response to treatment in psychiatric disorders. As it plays a role in the pathophysiological development of schizophrenia and bipolar disorder, it is of interest to study its role in predicting therapeutic responses in both [...] Read more.
Brain-derived neurotrophic factor (BDNF) is a potential biomarker of response to treatment in psychiatric disorders. As it plays a role in the pathophysiological development of schizophrenia and bipolar disorder, it is of interest to study its role in predicting therapeutic responses in both conditions. We carried out a systematic review of the literature, looking for differences in baseline BDNF levels and the Val66Met BDNF polymorphism in these disorders between responders and non-responders, and found information showing that the Val/Val genotype and higher baseline BDNF levels may be present in patients that respond successfully to pharmacological and non-pharmacological treatments. However, there is still limited evidence to support the role of the Val66Met polymorphism and baseline BDNF levels as predictors of treatment response. Full article
(This article belongs to the Special Issue Brain Plasticity in Health and Disease)
Show Figures

Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Back to TopTop