Growth Hormone and Human Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 February 2025 | Viewed by 7106
Special Issue Editor
Interests: growth hormone (GH) deficiency; GH insensitivity; GH therapy; insulin-like growth factors (IGF); IGF binding proteins; intrauterine growth retardation; fetal programming; personalized medicine; artificial neural networks; prediction models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The main function of the growth hormone (GH) in childhood is to promote linear growth until bone epiphyses are closed, while the metabolic effects of GH are important throughout life. Thus, GH substitution is a standard treatment in children with GH deficiency (GHD) and in adults with severe GHD. The beneficial effects of using GH administrations in some diseases not related to GH deficiency have also been documented and GH therapy has been approved for indications other than GHD. Examples of genetically determined disorders, in which GH therapy is fully approved for growth promotion, include Turner syndrome (TS) and Prader–Willi syndrome (PWS). In the case of PWS, the effects of early GH therapy (not only on metabolism, but also on cognitive and adaptive performance of treated children) are also of huge significance. In recent years, there is increasing interest in the beneficial effects of the GH on the repair of brain damage. It has also been reported that exogenous GH may have beneficial effects in children with the glucocorticoid-induced retardation of bone growth. Other indications for GH therapy are related to poor gonadal function and infertility, e.g., beneficial effects of GH administration during controlled ovarian stimulation have been documented in previously poor-responding or non-responding women. On the other hand, GH excess is related to the increased risk of different cancers and to a variety of other complications, as observed in the patients with gigantism/acromegaly. Molecular mechanisms of GH action, both directly in target tissues and indirectly via growth factors, are being better understood, but still require full explanations.
Researchers are invited to submit their original research or reviews for this Special Issue of the International Journal of Molecular Sciences, entitled “Growth Hormone and Human Disease”, which will cover the topics mentioned above or other issues related to different aspects of GHD, GH therapy, and GH excess.
Dr. Joanna Smyczyńska
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
