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Latest Advances in Metabolic Syndrome

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 January 2025) | Viewed by 3028

Special Issue Editor

Special Issue Information

Dear Colleagues,

I am honoured to extend an invitation to participate in our highly anticipated Special Issue, “Latest Advances in Metabolic Syndrome”. This issue is a significant milestone in our collective efforts to understand and manage metabolic syndrome.

MetS is a cluster of conditions that elevate the likelihood of developing heart disease, stroke, chronic kidney diseases, metabolic dysfunction related to steatotic liver disease (MASLD), and type 2 diabetes. The current advancements in understanding and managing metabolic syndrome are focused on various aspects, including exploring genetic and molecular factors, applying lifestyle interventions, utilizing pharmacological treatments, and developing technological innovations. Important subjects that will be addressed include the following:

Current research is unveiling specific genetic markers and pathways associated with metabolic syndrome, shedding light on crucial findings in genomics, biomarkers, and the microbiome. These breakthroughs in genomics are enhancing our understanding of individual susceptibility and identifying potential targets for therapeutic intervention. Studies on the gut microbiota are revealing its profound impact on metabolic health. The ability to modify the gut microbiome through dietary treatments, probiotics, or prebiotics is proving to be a game-changer in influencing the different aspects of metabolic syndrome.

One of the most promising areas of research is the role of lifestyle interventions in managing metabolic syndrome. Personalized eating regimens based on individual genetic and metabolic profiles and innovative exercise programmes have shown great potential in improving metabolic health.

A novel pharmaceutical intervention is being developed to selectively target the biological mechanisms related to insulin resistance, obesity, and lipid metabolism. A combination of medications that target multiple aspects of metabolic syndrome can enhance treatment efficacy and simultaneously address various components.

Examining the connection between inflammation, atherosclerosis, and metabolism is crucial in understanding metabolic syndrome. This relationship has led to the investigation of treatments and lifestyle modifications aimed at reducing systemic inflammation and atherosclerosis.

These developments underscore the importance of a holistic approach to understanding and managing metabolic syndrome. By integrating scientific research with practical therapies, we are making significant strides in our battle against this complex condition. This comprehensive approach should instil confidence in our ability to effectively address metabolic syndrome.

Dr. Anca Pantea Stoian
Guest Editor

Manuscript Submission Information

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Keywords

  • metabolic syndrome
  • MASLD
  • cardiovascular disease
  • obesity
  • chronic kidney disease
  • metabolic therapy
  • prediabetes
  • type 2 diabetes
  • metabolic inflammation
  • atherosclerosis
  • biomarkers
  • nutritional intervention

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Published Papers (1 paper)

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Review

17 pages, 1237 KiB  
Review
The Causal Role of Ectopic Fat Deposition in the Pathogenesis of Metabolic Syndrome
by Joseph A. M. J. L. Janssen
Int. J. Mol. Sci. 2024, 25(24), 13238; https://doi.org/10.3390/ijms252413238 - 10 Dec 2024
Viewed by 2666
Abstract
Consuming a “modern” Western diet and overnutrition may increase insulin secretion. Additionally, nutrition-mediated hyperinsulinemia is a major driver of ectopic fat deposition. The global prevalence of metabolic syndrome is high and growing. Within this context, people with congenital lipodystrophy often experience a severe [...] Read more.
Consuming a “modern” Western diet and overnutrition may increase insulin secretion. Additionally, nutrition-mediated hyperinsulinemia is a major driver of ectopic fat deposition. The global prevalence of metabolic syndrome is high and growing. Within this context, people with congenital lipodystrophy often experience a severe form of metabolic syndrome. Evidence is increasingly supporting that subtle partial lipodystrophy plays an important role in the development of metabolic syndrome in the general population. In individuals in the general population with subtle partial lipodystrophy, as well as in those with congenital lipodystrophy, the subcutaneous adipose tissues are unable to accommodate surplus energy intake. In both conditions, (excess) fat is directed toward the liver, pancreas, and muscles, where it is deposited as ectopic fat, as this fat can no longer be stored in the “safe” subcutaneous fat depots. Ectopic fat depositions cause insulin resistance in the liver and muscles, as well as β-cell dysfunction in the pancreas. Support of a direct pathological role of ectopic fat deposition in this condition is further provided by the rapid normalization of hepatic insulin sensitivity and improvement in pancreatic β-cell function after marked reductions in ectopic fat depositions. Thus, ectopic fat deposition in the liver, pancreas, and muscles may play a causal role in the pathogenesis of metabolic syndrome even in the general population. As such, the prevention of ectopic fat deposition may reduce the risk of metabolic syndrome and mitigate its effects. Full article
(This article belongs to the Special Issue Latest Advances in Metabolic Syndrome)
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