Molecular Mechanisms of Infection for Pathogenic Bacteria 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 5211
Special Issue Editor
Interests: genomics and proteomics; chemical structure; host interaction; health applications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue entitled Molecular Mechanisms of Infection for Pathogenic Bacteria.
The molecular mechanisms of infection for pathogenic bacteria can be now more easily characterized in terms of genomic and proteomic approaches. Pathogenic bacteria are diverse in their gene sets. Many virulence factors are maintained on a virulence plasmid and were acquired through horizontal gene transfer. Others were integrated into the chromosome by bacteriophages or transposable elements. Although the gain of traits is important in the evolution of a pathogen, the loss of certain genes is necessary to become fully pathogenic. We are beginning to dissect the interactions between virulence factors from pathogenic bacteria and host cell components. Several pathogenic molecules have been shown to hijack and manipulate host–cell processes for the benefit of the bacterium. Detailed knowledge of the molecular mechanisms of microbial pathogenicity is necessary in order to develop new strategies against infectious diseases and thus lower their impact on human health and social development. In this Special Issue, we will focus on these molecules, which represent infection mechanisms specially developed by pathogenic bacteria, either by increasing their virulence or by compromising the host defense.
Prof. Dr. Juan M. Tomás
Guest Editor
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Keywords
- bacterial pathogen
- infection
- molecules
- host defense
- infectious diseases
- human health
- infection models
- virulence factors
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