Compounds with Anxiolytic or Antidepressant Properties
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 7587
Special Issue Editors
Interests: neurosciences; inflammation; innate immunity
Interests: signalling pathways involved in psychiatric disorders, schizophrenia, depression; serotonin receptors; mTOR; biochemistry; electrophysiology; behavioral studies; proteomic
Special Issue Information
Dear Colleagues,
Major depression and anxiety are devastating disorders with a major impact on public health and important socio-economic costs. They are not homogeneous disorders, but complex phenomena with many subtypes and probably several etiologies.
There is no doubt that the monoaminergic system is one of the cornerstones of the pathological processes of depression, such that the currently used antidepressant drugs almost all target these systems. However, one-third of patients are totally resistant, feel no relief or relapse after such treatment. Therefore, novel therapeutic strategies are urgently needed.
Could endogenous molecules represent a new hope? Recent research highlights the fact that some endogenous neuropeptides, hormones and lipid neuromodulators may act directly or indirectly to counteract mood disorders. Among these endogenous molecules are a sortilin-derived peptide, digitalis-like compounds, thyroid hormones and endocannabinoids whose therapeutic potentials will be presented in this Special Issue. Additionally, a focus will be put on the adipose-derived hormones leptin and adiponectin, for which recent studies show their ability to fight against the establishment of anxiety and depression-like behaviors in rodents. This Special Issue will provide an overview of recent findings from basic and genetic research on the involvement of various endogenous molecules in the treatment of anxiety and mood disorders. Manipulating the levels of these hormones may eventually represent new therapeutic strategies to fight against depression.
Dr. Joëlle Chabry
Dr. Carine Becamel
Guest Editors
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Keywords
- antidepressant
- anti-anxiety
- endogenous compound
- neuraminidase
- histamine
- acetylcholine
- neurotransmitter
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