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Biomaterial Application in Sensors
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Biomaterial Application in Sensors

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (25 December 2018) | Viewed by 16887

Special Issue Editor

Dr. Abhijit Chatterjee

E-Mail Website
Guest Editor
BIOVIA Materials Science Principal Scientist, Dassault Systems Biovia K.K., ThinkPark Tower 21F, 2-1-1 Osaki, Shinagawa-ku, Tokyo 141-6020, Japan
Interests: density functional theory; material designing; computational chemistry; inorganic catalytic material; catalytic reactions; inorganic membrane;  transition state calculation; atomistic simulation; ab initio first principle calculation; reactivity index
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials is an important subject with a variety of applications in sensors. The biomaterial in focus is inorganic–organic hybrid materials applied to sensors. Examples can be from applications involving biometric applications, graphite interfaces, nanotube protein interactions, but is not limited to applications for sensors and can be expanded to bio mimicking materials. PZT-type materials are a good candidate to look into sensing capabilities, before and after surface polishing; which has immense applications in the semiconductor industry for MRAM. This Special Issue is looking for research articles and reviews focusing on a combination of experimental and computational simulation procedures, as a combination applied for new material designs or validation. This invitation is extended to application in material informatics to screen molecules of interest to design a property-specific new biomaterial.

Dr. Abhijit Chatterjee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • biomaterial
  • protein sensor
  • MRAM
  • informatics
  • sensor
  • computational modelling

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Published Papers (3 papers)

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Research

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19 pages, 6984 KiB  
Article
X-ray Structure Elucidation of a Pt-Metalloporphyrin and Its Application for Obtaining Sensitive AuNPs-Plasmonic Hybrids Capable of Detecting Triiodide Anions
by Eugenia Fagadar-Cosma, Anca Lascu, Sergiu Shova, Mirela-Fernanda Zaltariov, Mihaela Birdeanu, Lilia Croitor, Adriana Balan, Diana Anghel and Serban Stamatin
Int. J. Mol. Sci. 2019, 20(3), 710; https://doi.org/10.3390/ijms20030710 - 7 Feb 2019
Cited by 14 | Viewed by 4107
Abstract
The development of UV–vis spectrophotometric methods based on metalloporphyrins for fast, highly sensitive and selective anion detection, which avoids several of the practical challenges associated with other detection methods, is of tremendous importance in analytical chemistry. In this study, we focused on achieving [...] Read more.
The development of UV–vis spectrophotometric methods based on metalloporphyrins for fast, highly sensitive and selective anion detection, which avoids several of the practical challenges associated with other detection methods, is of tremendous importance in analytical chemistry. In this study, we focused on achieving a selective optical sensor for triiodide ion detection in traces based on a novel hybrid material comprised of Pt(II) 5,10,15,20-tetra(4-methoxy-phenyl)-porphyrin (PtTMeOPP) and gold nanoparticles (AuNPs). This sensor has high relevance in medical physiological tests. The structure of PtTMeOPP was investigated by single crystal X-ray diffraction in order to understand the metal surroundings and the molecule conformation and to assess if it qualifies as a potential sensitive material. It was proven that the Pt-porphyrin generated 1D H-bond supramolecular chains due to the weak C-H···O intermolecular hydrogen bonding. The presence of ordered voids in the crystal encouraged us to use PtTMeOPP as the sensing material for triiodide ion and to enhance its potential in a novel AuNPs/PtTMeOPP hybrid by the synergistic effects provided by the plasmonic gold nanoparticles. The spectrophotometric sensor is characterized by a detection limit of 1.5 × 10−9 M triiodide ion concentration and a remarkable confidence coefficient of 99.98%. Full article
(This article belongs to the Special Issue Biomaterial Application in Sensors)
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Review

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12 pages, 234 KiB  
Review
Recent Advances in Protein Kinase Activity Analysis Based on Nanomaterials
by Zhiyong Yan, Pingye Deng and Yang Liu
Int. J. Mol. Sci. 2019, 20(6), 1440; https://doi.org/10.3390/ijms20061440 - 21 Mar 2019
Cited by 14 | Viewed by 3546
Abstract
Protein phosphorylation regulated by protein kinases, as well as their dephosphorylation, is one of the most common post-translational modifications, and plays important roles in physiological activities, such as intracellular signal communications, gene transcription, cell proliferation and apoptosis. Over-expression of protein kinases is closely [...] Read more.
Protein phosphorylation regulated by protein kinases, as well as their dephosphorylation, is one of the most common post-translational modifications, and plays important roles in physiological activities, such as intracellular signal communications, gene transcription, cell proliferation and apoptosis. Over-expression of protein kinases is closely associated with various diseases. Consequently, accurate detection of protein kinases activities and their relevant inhibitors screening is critically important, not only to the biochemical research, but also to the clinical diagnosis and therapy. Nanomaterials, taking advantage of large surface areas, as well as excellent electrical, catalytic, magnetic and optical properties, have been utilized as target concentrators, recognition components, signal transducer or amplification elements in protein kinase related assays. This review summarizes the recent representative works to highlight the applications of nanomaterials in different biosensor technologies for protein kinases activities detection and their inhibitors screening. First, different nanomaterials developed for phosphoprotein/phosphopeptide enrichment and phosphate recognition are introduced. Next, representative works are selected that mainly focus on the utilization of nanomaterials as signal transducer or amplification elements in various protein kinases sensing platforms, such as electrochemical, colorimetric, fluorescent, and mass spectroscopy-based approaches. Finally, the major challenges and perspectives of nanomaterials being applied in protein kinases related assays are discussed. Full article
(This article belongs to the Special Issue Biomaterial Application in Sensors)
19 pages, 2804 KiB  
Review
Antifouling (Bio)materials for Electrochemical (Bio)sensing
by Susana Campuzano, María Pedrero, Paloma Yáñez-Sedeño and José M. Pingarrón
Int. J. Mol. Sci. 2019, 20(2), 423; https://doi.org/10.3390/ijms20020423 - 19 Jan 2019
Cited by 95 | Viewed by 8737
Abstract
(Bio)fouling processes arising from nonspecific adsorption of biological materials (mainly proteins but also cells and oligonucleotides), reaction products of neurotransmitters oxidation, and precipitation/polymerization of phenolic compounds, have detrimental effects on reliable electrochemical (bio)sensing of relevant analytes and markers either directly or after prolonged [...] Read more.
(Bio)fouling processes arising from nonspecific adsorption of biological materials (mainly proteins but also cells and oligonucleotides), reaction products of neurotransmitters oxidation, and precipitation/polymerization of phenolic compounds, have detrimental effects on reliable electrochemical (bio)sensing of relevant analytes and markers either directly or after prolonged incubation in rich-proteins samples or at extreme pH values. Therefore, the design of antifouling (bio)sensing interfaces capable to minimize these undesired processes is a substantial outstanding challenge in electrochemical biosensing. For this purpose, efficient antifouling strategies involving the use of carbon materials, metallic nanoparticles, catalytic redox couples, nanoporous electrodes, electrochemical activation, and (bio)materials have been proposed so far. In this article, biomaterial-based strategies involving polymers, hydrogels, peptides, and thiolated self-assembled monolayers are reviewed and critically discussed. The reported strategies have been shown to be successful to overcome (bio)fouling in a diverse range of relevant practical applications. We highlight recent examples for the reliable sensing of particularly fouling analytes and direct/continuous operation in complex biofluids or harsh environments. Opportunities, unmet challenges, and future prospects in this field are also pointed out. Full article
(This article belongs to the Special Issue Biomaterial Application in Sensors)
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