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cGAS-STING Innate Immunity Pathway
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cGAS-STING Innate Immunity Pathway

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 5713

Special Issue Editor

Prof. Dr. Michael Roth

E-Mail Website
Guest Editor
Pulmonary Cell Research/Pneumology, Department of Biomedicine/Internal Medicine, University & University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland
Interests: tissue remodeling in chronic lung diseases; asthma; COPD; lung fibrosis; epi-genetics; cell signaling; cell differentiation; epithelial cells; fibroblasts; airway smooth muscle cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you to contribute to a Special Issue on the topic of the cGAS-STING innate immunity pathway. The regulation of innate immunity is essential for host defence against viral, bacterial and mycotic infections, but may also play a role in allergic diseases. It would be of particular interest to obtain more detailed information regarding how pattern recognition receptors (DAMP and PAMP) interfere with or regulate cGAS-STING signalling and the innate immune response. Another point of interest is the existance of possible feedback mechanisms between the innate immune system and cGAS-STING signalling. This Special Issue will accept reviews and original research articles.

Prof. Dr. Michael Roth
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cGAS-STING
  • DAMP
  • PAMP
  • infection
  • inflammation

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Published Papers (2 papers)

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Research

12 pages, 11070 KiB  
Article
STING Agonist-Induced Skin Inflammation Is Exacerbated with Prior Systemic Innate Immune Activation
by Marcelina Pyclik, Justyna Durslewicz, Joanna A. Papinska, Umesh S. Deshmukh and Harini Bagavant
Int. J. Mol. Sci. 2023, 24(4), 4128; https://doi.org/10.3390/ijms24044128 - 18 Feb 2023
Cited by 4 | Viewed by 2780
Abstract
Activation of the Stimulator of Interferon Genes (STING) protein has paradoxical outcomes in skin disease. STING activation exacerbates psoriatic skin disease and delays wound healing in diabetic mice, yet it also facilitates wound healing in normal mice. To address the role of localized [...] Read more.
Activation of the Stimulator of Interferon Genes (STING) protein has paradoxical outcomes in skin disease. STING activation exacerbates psoriatic skin disease and delays wound healing in diabetic mice, yet it also facilitates wound healing in normal mice. To address the role of localized STING activation in the skin, mice were injected subcutaneously with a STING agonist, diamidobenzimidazole STING Agonist-1 (diAbZi). The effect of a prior inflammatory stimulus on STING activation was addressed by pre-treating mice intraperitoneally with poly (I:C). The skin at the injection site was evaluated for local inflammation, histopathology, immune cell infiltration, and gene expression. Serum cytokine levels were measured to assess systemic inflammatory responses. Localized diABZI injection induced severe skin inflammation with erythema, scaling, and induration. However, the lesions were self-limiting and resolved within 6 weeks. At the peak of inflammation, the skin showed epidermal thickening, hyperkeratosis, and dermal fibrosis. Neutrophils, CD3 T cells, and F4/80 macrophages were present in the dermis and subcutaneous layers. Gene expression was consistent with increased local interferon and cytokine signaling. Interestingly, the poly (I:C)-pre-treated mice showed higher serum cytokine responses and developed worse inflammation with delayed wound resolution. Our study demonstrates that prior systemic inflammation amplifies STING-mediated inflammatory responses and skin disease. Full article
(This article belongs to the Special Issue cGAS-STING Innate Immunity Pathway)
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16 pages, 2863 KiB  
Article
The Lack of STING Impairs the MHC-I Dependent Antigen Presentation and JAK/STAT Signaling in Murine Macrophages
by Carmen Caiazza, Teresa Brusco, Federica D’Alessio, Massimo D’Agostino, Angelica Avagliano, Alessandro Arcucci, Concetta Ambrosino, Giuseppe Fiume and Massimo Mallardo
Int. J. Mol. Sci. 2022, 23(22), 14232; https://doi.org/10.3390/ijms232214232 - 17 Nov 2022
Cited by 7 | Viewed by 2530
Abstract
STING is a transmembrane ER resident protein that was initially described as a regulator of innate immune response triggered by viral DNA and later found to be involved in a broader range of immune processes. Here, we assessed its role in the antigen [...] Read more.
STING is a transmembrane ER resident protein that was initially described as a regulator of innate immune response triggered by viral DNA and later found to be involved in a broader range of immune processes. Here, we assessed its role in the antigen presentation by generating a STING KO macrophage cell line. In the absence of STING, we observed an impaired OVA-derived SIINFEKL peptide presentation together with a decreased level of MHC-I complex on the plasma membrane, likely due to a decreased mRNA expression of β2 m light chain as no relevant alterations of the peptide-loading complex (TAPs) were found. Moreover, JAK-STAT signaling resulted in impaired STING KO cells following OVA and LPS treatments, suggesting a dampened activation of immune response. Our data revealed a new molecular role of STING in immune mechanisms that could elucidate its role in the pathogenesis of autoimmune disorders and cancer. Full article
(This article belongs to the Special Issue cGAS-STING Innate Immunity Pathway)
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