Gene and Cell-Based Cancer Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 9683
Special Issue Editors
Interests: cancer; fibrosis; stem/progenitor cell biology; gene therapy; cell therapy
Interests: breast and ovarian cancer; complementary and alternative medicine for reproductive health
Special Issue Information
Dear Colleagues,
Since the discovery of recombinant DNA technology and our increasing ability to transfer gene(s) from organism to organism, the idea of gene therapy to cure inherited human diseases took shape. As the structures and biology of the common bacteria and viruses infecting humans became known, they were engineered to carry therapeutic genes of interest and deliver them in desired tissues/organs. After some initial hurdles, gene therapy has come a long way, as evidenced by the growing number of clinical trials and approvals by the FDA and the EMA for clinical use. In contrast, cancer gene therapy is in the works with modest success, which is primarily due to heterogeneity in the disease process. Gene therapy can be a game changer for the treatment of cancers, mainly childhood cancers in offering long-term cures. CAR-T cell therapy, which was recently approved for human use for certain blood cancers, is an extension of gene therapy involving genetic modification of patient’s T-cells ex vivo to efficiently recognize and kill cancer cells when given back to the patient. There is room for improvement, and the race is on to extend its scope to solid tumors. In this Special Issue, we will celebrate your original research or review articles enriching the promise of gene- and cell-based therapies in cancer. IJMS MDPI is a peer-reviewed open-access journal with a high impact factor representing a great way to reach out to a broad readership who can also immensely benefit from your work. Therefore, we are encouraging you to submit your valuable observations, findings and vision to IJMS. Thank you.
The topics of interest for our Special Issue include but are not limited to:
- Technological advancements in vector design for cancer gene therapy;
- Application of gene and cell therapy in different cancer types;
- Use of gene editing technologies in cancer treatments;
- Induced pluripotent stem-cell-based cancer therapies;
- Tumor-specific gene targeting methods;
- Immunomodulation in cancer treatments;
- Cancer cell reprogramming by gene transfers
Dr. Indrajit Chowdhury
Guest Editors
Manuscript Submission Information
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Keywords
- cancer
- oncology
- metastasis
- stem cells
- gene therapy
- cell therapy
- immunotherapy
- CRISPR-cas9
- gene editing
- induced pluripotent stem cells
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