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Honey and Other Beehive Products: A New Light from a Cellular and Molecular Perspective

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 4463

Special Issue Editors


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Guest Editor
DiSIT - Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale "Amedeo Avogadro", Viale Teresa Michel 11, 15121 Alessandria, Italy
Interests: cell biology; cancer; calcium signalling; confocal microscopy; wound repair; honey; honeybee products; natural compounds; malignant mesothelioma
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Special Issue Information

Dear Colleagues,

This Special Issue, Honey and Other Beehive Products: A New Light from a Cellular and Molecular Perspective, will cover a selection of research and review articles in the field of emerging properties of honey and other honeybee products (e.g., propolis, honeydew honey, etc.) in the light of cellular and molecular aspects boosted by the application of these compounds.

Since Biblical times and before, honey has been known to have beneficial health effects, and is still widely used in “folk medicine”. Recently, the therapeutic virtues of honey have been rediscovered by the medical profession and are gaining acceptance for the treatment of ulcers, wounds, and other surface infections.

However, in spite of a substantial body of literature about honey’s clinical uses, the subjacent mechanisms of action are still largely obscure. In a number of cases, beneficial effects have been ascribed to antiseptic properties, but accumulating data suggest the involvement of other specific biochemical and physiological mechanisms, which this Special Issue will explore.

Contributions to this Special Issue may cover all aspects of cellular and molecular events induced by honeybee products: not only their antibacterial proprieties in wound repair, but also elucidation of their positive effects on cells.

Dr. Elia Ranzato
Dr. Simona Martinotti
Guest Editors

Manuscript Submission Information

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Keywords

  • honey
  • propolis
  • beehive products
  • natural products
  • cell signaling
  • Ca2+ signaling
  • confocal microscopy
  • honey composition
  • wound repair
  • antibacterial properties

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Published Papers (1 paper)

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Research

19 pages, 2953 KiB  
Article
Elimination of Teratogenic Human Induced Pluripotent Stem Cells by Bee Venom via Calcium-Calpain Pathway
by Aeyung Kim, Seo-Young Lee, Bu-Yeo Kim and Sun-Ku Chung
Int. J. Mol. Sci. 2020, 21(9), 3265; https://doi.org/10.3390/ijms21093265 - 5 May 2020
Cited by 11 | Viewed by 3540
Abstract
Induced pluripotent stem cells (iPSCs) are regarded as a promising option for cell-based regenerative medicine. To obtain safe and efficient iPSC-based cell products, it is necessary to selectively eliminate the residual iPSCs prior to in vivo implantation due to the risk of teratoma [...] Read more.
Induced pluripotent stem cells (iPSCs) are regarded as a promising option for cell-based regenerative medicine. To obtain safe and efficient iPSC-based cell products, it is necessary to selectively eliminate the residual iPSCs prior to in vivo implantation due to the risk of teratoma formation. Bee venom (BV) has long been used in traditional Chinese medicine to treat inflammatory diseases and relieve pain, and has been shown to exhibit anti-cancer, anti-mutagenic, anti-nociceptive, and radioprotective activities. However, the potential benefits of BV in iPSC therapy, particularly its anti-teratoma activity, have not been examined. In this study, we found that BV selectively induced cell death in iPSCs, but not in iPSC-derived differentiated cells (iPSCs-Diff). BV rapidly disrupted cell membrane integrity and focal adhesions, followed by induction of apoptosis and necroptosis in iPSCs. We also found that BV remarkably enhanced intracellular calcium levels, calpain activation, and reactive oxygen speciesgeneration in iPSCs. BV treatment before in ovo grafting efficiently prevented iPSC-derived teratoma formation. In contrast, no DNA damage was observed in iPSCs-Diff following BV treatment, further demonstrating the safety of BV for use with iPSCs-Diff. Taken together, these findings show that BV has potent anti-teratoma activity by eliminating residual iPSCs, and can be used for the development of effective and safe iPSC-based cell therapies. Full article
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