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Novel Natural Compound for Wound and Tissue Repair and Regeneration: 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 7451

Special Issue Editors

Dr. Elia Ranzato

E-Mail Website
Guest Editor
DiSIT-Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Viale Teresa Michel 11, 15121 Alessandria, Italy
Interests: cell biology; wound repair; calcium signalling
Special Issues, Collections and Topics in MDPI journals
Dr. Simona Martinotti

E-Mail Website
Guest Editor
DiSIT - Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale "Amedeo Avogadro", Viale Teresa Michel 11, 15121 Alessandria, Italy
Interests: cell biology; cancer; calcium signalling; confocal microscopy; wound repair; honey; honeybee products; natural compounds; malignant mesothelioma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous successful Special Issue “Novel Natural Compound for Wound and Tissue Repair and Regeneration”.

Wound healing is of great importance for skin medicine, with particular interest focused on natural compounds.

Numerous studies have recognized the potential use of natural products as wound-healing agents in terms of their antibacterial, antioxidant, immunomodulatory, and pro-collagen synthesis properties.

The therapeutic virtues of natural compounds have been rediscovered by the medical profession and are gaining acceptance with regard to treating wounds, ulcers, and other surface infections.

Despite the extensive literature available on the clinical uses of natural compounds, the subjacent mechanisms remain largely unknown. With the growing interest in the utilization of natural products and the belief that they are safer than standard therapies, it is crucial that we enhance our knowledge of their efficacy and side effects.

Thus, original articles and reviews that investigate the positive effects of natural compounds on wound healing and the cellular and molecular mechanisms that are involved will be suitable for this Special Issue.

Dr. Elia Ranzato
Dr. Simona Martinotti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound repair
  • tissue regeneration
  • natural compounds
  • phytochemicals
  • molecular mechanisms

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Related Special Issues

Published Papers (4 papers)

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Research

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19 pages, 7612 KiB  
Article
Chondroitin Sulfate for Cartilage Regeneration, Administered Topically Using a Nanostructured Formulation
by Marta E. Bustos Araya, Anna Nardi-Ricart, Ana C. Calpena Capmany and Montserrat Miñarro Carmona
Int. J. Mol. Sci. 2024, 25(18), 10023; https://doi.org/10.3390/ijms251810023 - 18 Sep 2024
Viewed by 3798
Abstract
In the pharmaceutical sector, solid lipid nanoparticles (SLN) are vital for drug delivery incorporating a lipid core. Chondroitin sulfate (CHON) is crucial for cartilage health. It is often used in osteoarthritis (OA) treatment. Due to conflicting results from clinical trials on CHON’s efficacy [...] Read more.
In the pharmaceutical sector, solid lipid nanoparticles (SLN) are vital for drug delivery incorporating a lipid core. Chondroitin sulfate (CHON) is crucial for cartilage health. It is often used in osteoarthritis (OA) treatment. Due to conflicting results from clinical trials on CHON’s efficacy in OA treatment, there has been a shift toward exploring effective topical systems utilizing nanotechnology. This study aimed to optimize a solid lipid nanoparticle formulation aiming to enhance CHON permeation for OA therapy. A 3 × 3 × 2 Design of these experiments determined the ideal parameters: a CHON concentration of 0.4 mg/mL, operating at 20,000 rpm speed, and processing for 10 min for SLN production. Transmission electron microscopy analysis confirmed the nanoparticles’ spherical morphology, ensuring crucial uniformity for efficient drug delivery. Cell viability assessments showed no significant cytotoxicity within the tested parameters, indicating a safe profile for potential clinical application. The cell internalization assay indicates successful internalization at 1.5 h and 24 h post-treatment. Biopharmaceutical studies supported SLNs, indicating them to be effective CHON carriers through the skin, showcasing improved skin permeation and CHON retention compared to conventional methods. In summary, this study successfully optimized SLN formulation for efficient CHON transport through pig ear skin with no cellular toxicity, highlighting SLNs’ potential as promising carriers to enhance CHON delivery in OA treatment and advance nanotechnology-based therapeutic strategies in pharmaceutical formulations. Full article
(This article belongs to the Special Issue Novel Natural Compound for Wound and Tissue Repair and Regeneration: 3rd Edition)
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14 pages, 1977 KiB  
Article
Hyaluronic Acid/Ellagic Acid as Materials for Potential Medical Application
by Beata Kaczmarek-Szczepańska, Konrad Kleszczyński, Lidia Zasada, Dorota Chmielniak, Mara Barbara Hollerung, Katarzyna Dembińska, Krystyna Pałubicka, Kerstin Steinbrink, Maria Swiontek Brzezinska and Sylwia Grabska-Zielińska
Int. J. Mol. Sci. 2024, 25(11), 5891; https://doi.org/10.3390/ijms25115891 - 28 May 2024
Viewed by 1155
Abstract
The aim of this work was to develop and characterize a thin films composed of hyaluronic acid/ellagic acid for potential medical application. Its principal novelty, distinct from the prior literature in terms of hyaluronic acid films supplemented with phenolic acids, resides in the [...] Read more.
The aim of this work was to develop and characterize a thin films composed of hyaluronic acid/ellagic acid for potential medical application. Its principal novelty, distinct from the prior literature in terms of hyaluronic acid films supplemented with phenolic acids, resides in the predominant incorporation of ellagic acid—a distinguished compound—as the primary constituent of the films. Herein, ellagic acid was dissolved in two different solvents, i.e., acetic acid (AcOH) or sodium hydroxide (NaOH), and the surface properties of the resultant films were assessed using atomic force microscopy and contact angle measurements. Additionally, various physicochemical parameters were evaluated including moisture content, antioxidant activity, and release of ellagic acid in phosphate buffered saline. Furthermore, the evaluation of films’ biocompatibility was conducted using human epidermal keratinocytes, dermal fibroblasts, and human amelanotic melanoma cells (A375 and G361), and the antimicrobial activity was elucidated accordingly against Staphylococcus aureus ATCC 6538 and Pseudomonas aeruginosa ATCC 15442. Our results showed that the films exhibited prominent antibacterial properties particularly against Staphylococcus aureus, with the 80HA/20EA/AcOH film indicating the strong biocidal activity against this strain leading to a significant reduction in viable cells. Comparatively, the 50HA/50EA/AcOH film also displayed biocidal activity against Staphylococcus aureus. This experimental approach could be a promising technique for future applications in regenerative dermatology or novel strategies in terms of bioengineering. Full article
(This article belongs to the Special Issue Novel Natural Compound for Wound and Tissue Repair and Regeneration: 3rd Edition)
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15 pages, 13912 KiB  
Article
Gelatin Enhances the Wet Mechanical Properties of Poly(D,L-Lactic Acid) Membranes
by Deuk Yong Lee
Int. J. Mol. Sci. 2024, 25(9), 5022; https://doi.org/10.3390/ijms25095022 - 4 May 2024
Viewed by 1120
Abstract
Biodegradable (BP) poly(D,L-lactic acid) (PDLLA) membranes are widely used in tissue engineering. Here, we investigate the effects of varying concentrations of PDLLA/gelatin membranes electrospun in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP; C3H2F6O) solvent on their mechanical and physical properties as well [...] Read more.
Biodegradable (BP) poly(D,L-lactic acid) (PDLLA) membranes are widely used in tissue engineering. Here, we investigate the effects of varying concentrations of PDLLA/gelatin membranes electrospun in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP; C3H2F6O) solvent on their mechanical and physical properties as well as their biocompatibility. Regardless of the environmental conditions, increasing the gelatin content resulted in elevated stress and reduced strain at membrane failure. There was a remarkable difference in strain-to-failure between dry and wet PDLLA/gelatin membranes, with wet strains consistently higher than those of the dry membranes because of the hydrophilic nature of gelatin. A similar wet strain (εw = 2.7–3.0) was observed in PDLLA/gelatin membranes with a gelatin content between 10 and 40%. Both dry and wet stresses increased with increasing gelatin content. The dry stress on PDLLA/gelatin membranes (σd = 6.7–9.7 MPa) consistently exceeded the wet stress (σw = 4.5–8.6 MPa). The water uptake capacity (WUC) improved, increasing from 57% to 624% with the addition of 40% gelatin to PDLLA. PDLLA/gelatin hybrid membranes containing 10 to 20 wt% gelatin exhibited favorable wet mechanical properties (σw = 5.4–6.3 MPa; εw = 2.9–3.0); WUC (337–571%), degradability (11.4–20.2%), and excellent biocompatibility. Full article
(This article belongs to the Special Issue Novel Natural Compound for Wound and Tissue Repair and Regeneration: 3rd Edition)
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Review

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31 pages, 3143 KiB  
Review
Application of Fetal Membranes and Natural Materials for Wound and Tissue Repair
by Marion Rouzaire, Loïc Blanchon, Vincent Sapin and Denis Gallot
Int. J. Mol. Sci. 2024, 25(22), 11893; https://doi.org/10.3390/ijms252211893 - 5 Nov 2024
Viewed by 510
Abstract
The human fetal membrane is a globally accepted biological biomaterial for wound and tissue repair and regeneration in numerous fields, including dermatology, ophthalmology, and more recently orthopedics, maxillofacial and oral surgery, and nerve regeneration. Both cells and matrix components of amnion and chorion [...] Read more.
The human fetal membrane is a globally accepted biological biomaterial for wound and tissue repair and regeneration in numerous fields, including dermatology, ophthalmology, and more recently orthopedics, maxillofacial and oral surgery, and nerve regeneration. Both cells and matrix components of amnion and chorion are beneficial, releasing a diverse range of growth factors, cytokines, peptides, and soluble extracellular matrix components. Beside fetal membranes, numerous natural materials have also been reported to promote wound healing. The biological properties of these materials may potentiate the pro-healing action of fetal membranes. Comparison of such materials with fetal membranes has been scant, and their combined use with fetal membranes has been underexplored. This review presents an up-to-date overview of (i) clinical applications of human fetal membranes in wound healing and tissue regeneration; (ii) studies comparing human fetal membranes with natural materials for promoting wound healing; and (iii) the literature on the combined use of fetal membranes and natural pro-healing materials. Full article
(This article belongs to the Special Issue Novel Natural Compound for Wound and Tissue Repair and Regeneration: 3rd Edition)
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