Insulin Peptides, Adipokines and Incretins in Reproduction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 6484
Special Issue Editors
Interests: signal transduction; allosteric site; allosteric regulator; positive allosteric modulator; negative allosteric modulator; hormone; growth factor; cytokine; heterotrimeric G-protein; adenylyl cyclase; G-protein-coupled receptor; tyrosine kinase receptor; cytokine receptor; receptor complex; insulin; leptin; interleukin; epidermal growth factor; central nervous system; endocrine system; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Interests: signal transduction; allosteric site; allosteric regulator; positive allosteric modulator; negative allosteric modulator; hormone; growth factor; cytokine; heterotrimeric G-protein; adenylyl cyclase; G-protein-coupled receptor; tyrosine kinase receptor; cytokine receptor; receptor complex; insulin; leptin; interleukin; epidermal growth factor; central nervous system; endocrine system; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The main regulatory component of the reproductive system in humans and vertebrates is the hypothalamic–pituitary–gonadal (HPG) axis that includes hypothalamic GnRH-expressing neurons, gonadotropin-producing pituitary gonadotrophs, and gonads containing somatic and germ cells. In addition to GnRH, gonadotropins, and steroid hormones (androgens, estrogens, progesterone), the HPG axis is regulated by a variety of hormones, neurotransmitters, growth factors, cytokines, vitamins, reactive oxygen species, and others. In recent years, insulin and related peptides (insulin-like growth factor-1, insulin-like factor 3), adipokines (leptin, adiponectin, resistin, visfatin, chemerin, omentin, irisin, apelin, fatty acid binding protein-4), and incretins (glucagon-like peptide-1, ghrelin, gastric inhibitory polypeptide, nesfatin-1) have attracted the greatest amount of interest. They play a key role in normal regulation of the HPG axis and are also involved in the etiology and pathogenesis of reproductive disorders, including those caused by diabetes, metabolic syndrome, and aging. Deciphering and studying the molecular mechanisms of the action of insulin peptides, adipokines, and incretins on reproduction, as well as establishing the role of their signaling systems in development and pathogenesis of reproductive dysfunctions, infertility, miscarriage, and gestational diabetes, are the most acute problems of endocrinology and reproductive medicine. The proposed Special Issue is devoted to the solution and discussion of these problems.
The main topics are (1) insulin and insulin-like peptides in regulation of steroidogenesis, spermatogenesis and folliculogenesis; (2) involvement of insulin peptides, adipokines, and incretins in hypothalamic regulation of the HPG axis; (3) crosstalk between the somatotropic (growth hormone/IGF-1) and gonadal axes; (4) leptin, adiponectin, and other adipokines as regulators of steroidogenesis, folliculogenesis, and gametogenesis; (5) incretins in control of male and female reproduction; (6) insulin/leptin resistance and adipokine/incretin imbalance in etiology and pathogenesis of polycystic ovary syndrome; (7) insulin therapy as an approach to treat diabetes-associated reproductive disorders and gestational diabetes; (8) pharmacotherapy of reproductive diseases with drugs targeting adipokine and incretin signaling; (9) gut microbiome and reproduction (participation of incretins, insulin peptides, cytokines); (10) energy metabolism and reproduction/fertility: from hypothalamus to gonads; and (11) age-dependent changes in insulin, adipokines, and incretin signaling on reproduction: from embryo to puberty to adulthood. The content of the Special Issue is not limited to these topics, however.
Authors are invited to submit original and review articles for publication in this Special Issue of IJMS.
Prof. Dr. Alexander Shpakov
Dr. Kira V. Derkach
Guest Editors
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Keywords
- hypothalamic–pituitary–gonadal (HPG) axis
- ovary
- testes
- reproduction
- steroidogenesis
- spermatogenesis
- folliculogenesis
- oogenesis
- gonadoliberin
- gonadotropin
- luteinizing hormone
- follicle-stimulating hormone
- testosterone
- estradiol
- progesterone
- insulin family
- insulin
- insulin growth factor 1
- insulin-like factor 3
- adipokines
- leptin
- adiponectin
- apelin
- visfatin
- resistin
- chemerin
- omentin
- irisin
- fatty acid binding protein 4
- incretins
- glucagon-like peptide 1
- ghrelin
- gastric inhibitory polypeptide
- nesfatin-1
- granulosa cells
- theca cells
- Leydig cells
- Sertoli cells
- spermatozoa
- fertility
- oocyte maturation
- embryo development
- polycystic ovary syndrome
- gestational diabetes
- male hypogonadism
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