Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Group I Metabotropic Glutamate Receptors: Physiological and Pathological Roles
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Group I Metabotropic Glutamate Receptors: Physiological and Pathological Roles

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 6018

Special Issue Editors

Dr. Ada Ledonne

E-Mail Website
Guest Editor
Department of Experimental Neuroscience, Foundation Santa Lucia, Rome, Italy
Interests: neurophysiology; neuropharmacology; neurotransmission; synaptic plasticity; dopaminergic system; mGluRI; neuregulins; neuropsychiatric disorders; Parkinson's disease
Prof. Dr. Nicola B. Mercuri

E-Mail Website
Guest Editor
IRCCS Fondazione Santa Lucia, Rome, Italy
Interests: neurodegenerative diseases; autoimmune diseases of the central and peripheral nervous system; neuroprotective drugs

Special Issue Information

Dear Colleagues,

Group I metabotropic glutamate receptors (mGluRI), including mGluR1 and mGluR5 subtypes, are Gq/11-coupled receptors with a widespread expression in the brain. mGluRI are essential for proper brain functioning: they affect neuronal excitability, neurotransmission and synaptic plasticity, thus directly mediating cellular mechanisms underlying learning and memory processes and complex behaviors. Moreover, unbalanced mGluRI-dependent mechanisms have been reported in several neurological and psychiatric illnesses.

The aim of this Special Issue is to collect original papers and reviews to feature recent advances on mGluRI-dependent effects in health and brain diseases. Specifically, manuscripts will be accepted that describe mGluRI signaling and interactome (scaffolding proteins, regulatory proteins and signaling effectors, or mGluRI assembly with other receptors/ion channels), mGluRI functions in neurons and glial cells, their roles in the regulation of synaptic plasticity, learning and memory processes and complex behaviors, both in physiological and pathological conditions, also including neurodevelopmental disorders, neurodegenerative diseases, and psychopathologies.

Dr. Ada Ledonne
Prof. Dr. Nicola Mercuri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mGluR1
  • mGluR5
  • mGluRI signaling
  • neurotransmission
  • synaptic plasticity
  • learning and memory
  • behavior
  • neurodevelopmental diseases
  • neurological and psychiatric disorders

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

Jump to: Other

15 pages, 1156 KiB  
Review
Group I Metabotropic Glutamate Receptors and Interacting Partners: An Update
by Li-Min Mao, Alaya Bodepudi, Xiang-Ping Chu and John Q. Wang
Int. J. Mol. Sci. 2022, 23(2), 840; https://doi.org/10.3390/ijms23020840 - 13 Jan 2022
Cited by 15 | Viewed by 2900
Abstract
Group I metabotropic glutamate (mGlu) receptors (mGlu1/5 subtypes) are G protein-coupled receptors and are broadly expressed in the mammalian brain. These receptors play key roles in the modulation of normal glutamatergic transmission and synaptic plasticity, and abnormal mGlu1/5 signaling is linked to the [...] Read more.
Group I metabotropic glutamate (mGlu) receptors (mGlu1/5 subtypes) are G protein-coupled receptors and are broadly expressed in the mammalian brain. These receptors play key roles in the modulation of normal glutamatergic transmission and synaptic plasticity, and abnormal mGlu1/5 signaling is linked to the pathogenesis and symptomatology of various mental and neurological disorders. Group I mGlu receptors are noticeably regulated via a mechanism involving dynamic protein–protein interactions. Several synaptic protein kinases were recently found to directly bind to the intracellular domains of mGlu1/5 receptors and phosphorylate the receptors at distinct amino acid residues. A variety of scaffolding and adaptor proteins also interact with mGlu1/5. Constitutive or activity-dependent interactions between mGlu1/5 and their interacting partners modulate trafficking, anchoring, and expression of the receptors. The mGlu1/5-associated proteins also finetune the efficacy of mGlu1/5 postreceptor signaling and mGlu1/5-mediated synaptic plasticity. This review analyzes the data from recent studies and provides an update on the biochemical and physiological properties of a set of proteins or molecules that interact with and thus regulate mGlu1/5 receptors. Full article
(This article belongs to the Special Issue Group I Metabotropic Glutamate Receptors: Physiological and Pathological Roles)
►▼ Show Figures

Figure 1

Other

Jump to: Review

8 pages, 663 KiB  
Opinion
Role of Group I Metabotropic Glutamate Receptors in Spike Timing-Dependent Plasticity
by Irene Martínez-Gallego, Antonio Rodríguez-Moreno and Yuniesky Andrade-Talavera
Int. J. Mol. Sci. 2022, 23(14), 7807; https://doi.org/10.3390/ijms23147807 - 15 Jul 2022
Cited by 6 | Viewed by 2454
Abstract
Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, including excitability and plasticity processes. Particularly, group I [...] Read more.
Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, including excitability and plasticity processes. Particularly, group I mGluRs located at the pre- or postsynaptic compartments are involved in spike timing-dependent plasticity (STDP) at hippocampal and neocortical synapses. Their roles of participating in the underlying mechanisms for detection of activity coincidence in STDP induction are debated, and diverse findings support models involving mGluRs in STDP forms in which NMDARs do not operate as classical postsynaptic coincidence detectors. Here, we briefly review the involvement of group I mGluRs in STDP and their possible role as coincidence detectors. Full article
(This article belongs to the Special Issue Group I Metabotropic Glutamate Receptors: Physiological and Pathological Roles)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop