The Emerging Roles of miRNAs in the Natural-Compound-Based Treatment of Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (28 October 2022) | Viewed by 3709
Special Issue Editors
Interests: cancer; angiogenesis; cell death, metastasis; animal science; molecular signaling pathways; natural compounds; sulfur; tannin; drug development; cancer immunotherapy
Special Issues, Collections and Topics in MDPI journals
Interests: cancer; angiogenesis; metastasis; inflammation; animal science; microbiology; molecular signaling pathways; natural compounds; sulfur; tannin; drug development
Special Issues, Collections and Topics in MDPI journals
2. Research Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania
Interests: drug analysis; drug product design and development; analytical technique; magnetic and metallic nanoparticles; polymeric nanoparticles; solid–lipid nanoparticles; drug–cyclodextrin inclusion; complexation; cell biology; biological active compounds; biomedical microbiology; biophysics; biochemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We invite the submission of manuscripts to a Special Issue of IJMS titled “The Emerging Roles of miRNAs in the Natural-Compound-Based Treatment of Cancer”, which will contain a selection of papers dealing with the molecular signaling of bioactive natural compounds in the regulation of microRNAs for cancer treatment. Original research reports, review articles, and commentaries are welcome.
Natural-compounds-based treatment for cancer is considered a good therapeutic method, as it lacks side effects when compared with chemotherapeutic drugs. Hence these natural compounds could also be considered for neoadjuvant therapy. There are many natural compounds that are well known for their anti-cancer activities, and the reason behind their anti-cancer activity is the presence of active components. However, the signaling mechanisms of these active compounds are still unclear in many cancers. MicroRNAs (miRNAs) take part in various cancer hallmarks by regulating other signaling pathways, inhibiting mRNA translation, and promoting mRNA degradation, resulting in the post-transcriptional alteration of gene expression. The activity of natural compounds also depends on how they regulate miRNA expression and thereby control tumorigenesis or tumor progression and metastasis. Hence, knowing the role of miRNAs in the activity of natural compounds for cancer treatment will help in developing new drugs based on natural compounds. These miRNAs also take part in tumor immune escape mechanism, and knowing their role when treating cancers with natural compounds could also enlighten the research on cancer immunotherapy.
This Special Issue aims to cover all aspects of bioactive natural compounds including, but not limited to, in vitro and in vivo activities, clinical effects, mechanisms of action, and signaling pathway elucidation. Papers dealing with the product development of active single components in natural nutraceuticals and dietary supplements or their synergistic combination treatment with commercially available anti-cancer drugs are also welcome.
Dr. Nipin Sp
Dr. Dong Young Kang
Prof. Dr. Codruta Soica
Guest Editors
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Keywords
- natural compounds
- dietary supplements
- molecular signaling pathways
- microRNAs
- microRNA sequencing
- cancer hallmarks
- cell cycle arrest and apoptosis
- tumor angiogenesis
- tumor metastasis
- cancer immunotherapy
- anti-cancer drug development
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