Molecular Mechanism of Action of Neonicotinoid Insecticides 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 3539
Special Issue Editor
Interests: neonicotinoid insecticides; insect neuronal nicotinic acetylcholine receptors; mammalian neuronal nicotinic receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neonicotinoid insecticides are used worldwide, although they have demonstrated toxicity towards beneficial insects such as honeybees. Their effectiveness is predominantly attributed to their high affinity for insect neuronal nicotinic acetylcholine receptors (nAChRs). Mammalian neuronal nAChRs are of major importance because cholinergic synaptic transmission plays a key role in rapid neurotransmission, learning and memory processes, and neurodegenerative diseases. Because of the low agonist effects of neonicotinoid insecticides on mammalian neuronal nAChRs, it has been suggested that they are relatively safe for mammals, including humans. However, several lines of evidence have demonstrated that neonicotinoid insecticides can modulate cholinergic functions through neuronal nAChRs. Major studies on the influence of neonicotinoid insecticides on cholinergic functions have been conducted using nicotine low-affinity homomeric α7 and high-affinity heteromeric α4β2 receptors, as they are highly abundant in the nervous system. Furthermore, neonicotinoids thiamethoxam and clothianidin can activate the release of dopamine in rat striatum. In some contexts, such as neurodegenerative diseases, they can disturb the neuronal distribution or induce oxidative stress, leading to neurotoxicity.
This Special Issue aims to explore the molecular mechanism of action of neonicotinoid insecticides through chemical analyses and toxicology studies, from the molecular to the cellular levels.
Prof. Dr. Steeve Hervé Thany
Guest Editor
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Keywords
- neonicotinoids
- toxicity
- chemistry
- mode of action
- nicotinic acetylcholine receptors
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