Nutrients and Nitrite
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 7708
Special Issue Editors
Interests: nitric oxide; nitrate/nitrite; crush syndrome; ischemia/reperfusion injury; reactive oxygen species
Special Issues, Collections and Topics in MDPI journals
Interests: nitric oxide; ischemia/reperfusion injury; crush syndrome
Interests: cell physiology; molecular biology; exercise physiology; nitric oxide; omega-3 fatty acids
Special Issues, Collections and Topics in MDPI journals
Interests: nutrition; nitrite; nitrate; nitric oxide; hypertension; cardiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although nitrate and nitrite were previously considered to be inert end products of endogenously produced nitric oxide (NO) in the process of NO oxygenation, they are now known to be physiologically recycled in the blood and tissue to form NO and other bioactive nitrogen oxides. Decreased NO availability, caused by obesity and endothelial dysfunction, might be causally related to the development of lifestyle-related diseases, such as insulin resistance, ischemic heart disease, and hypertension. However, dietary intake of nitrite as a nutrient may compensate NO synthase (NOS)-dependent NO generation through the enterosalivary nitrate-nitrite-NO pathway by transmitting NO activity in various molecular forms, including NO and protein S-nitrosothiols. Potential topics in this special issue may include the above-mentioned metabolic disorders but are not limited to the association of nitrite-mediated NO activity with lifestyle-related diseases. We would also like to extend the concept of this theme to the field of sports and exercise, maternal nutrition, breastfeeding during the perinatal period, and even to infectious diseases, including COVID-19, in which NO-mediated molecular mechanisms may be beneficially involved. In this special issue, we look forward to discussions on the prophylactic and therapeutic effects of nitrite intake as a nutrient in a variety of pathophysiological conditions.
Prof. Jun Kobayashi
Dr. Isamu Murata
Dr. Kazuo Ohtake
Dr. Kunihiro Sonoda
Guest Editors
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Keywords
- nitrate and nitrite
- nitric oxide (NO)
- enterosalivary-nitrate-nitrite-NO pathway
- microbial flora
- mitochondrial electron transport chain
- nitrosylation
- nitrosation
- ischemia/reperfusion injury
- oxidative stress
- crush syndrome
- breastfeeding
- lifestyle-related diseases
- COVID-19
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