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Translational Chemistry: From a Single Molecule to Biological Research
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Translational Chemistry: From a Single Molecule to Biological Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 August 2018) | Viewed by 15832

Special Issue Editors

Prof. Dr. Carlos Lodeiro

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Guest Editor
Inorganic Chemistry and NanoChemistry, NOVA School Of Science And Technology, FCT NOVA, NOVA University Lisbon, 2829-516 Caparica, Portugal
Interests: metallic nanoparticles; nanoproteomics; imaging; silica nanoparticles; catalysis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jose Luis Capelo

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Guest Editor
BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, NOVA University Lisbon, Caparica, Portugal
Interests: antibiotic resistance; MALDI-TOF mass spectrometry; analytical proteomics; biomarker discovery; analytical chemistry; biochemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Hugo Miguel Santos

E-Mail Website
Guest Editor
LAQV-REQUIMTE—Chemistry Department, NOVA School of Science and Technology, NOVA University Lisbon, Caparica, Portugal
Interests: nanoproteomics; biomarker discovery; personalised medicine; mass spectrometry
Special Issues, Collections and Topics in MDPI journals
Dr. Elisabete Oliveira

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Guest Editor
Chemistry Department, REQUIMTE, FCT-University NOVA of Lisbon, Lisbon, Portugal
Interests: mesoporous nanoparticles; nanoparticles; quantum dots; cancer research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are proud to announce the Special Issue, “Translational Chemistry: From a Single Molecule to Biological Research”, in the International Journal of Molecular Sciences (MDPI IMJS Editorial; IF: 3.226) devoted to The 2nd International Caparica Christmas Conference on Translational Chemistry (2nd IC3TC-2018). (http://www.ic3tc2017.com/).

The conference will be held in Costa de Caparica, Portugal, 4–7 December, 2017. This Special Issue will select excellent papers from the oral (plenary, keynotes, and regular talks) and posters participations, and covers a very wide range of fields in chemistry and translational chemistry applied in translational research, focusing on toxicological, biological, medical, pharmaceutical, nano and bio-medical applications. We invite investigators to contribute with original research articles, as well as review articles, to this Special Issue.

Prof. Carlos Lodeiro
Prof. Jose Luis Capelo
Dr. Hugo Miguel Santos
Dr. Elisabete Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Translational Research
  • Biochemistry
  • Biological Chemistry
  • Pharmacological Chemistry
  • Nanochemistry and Medicine
  • Translational Biomedicine research
  • Molecular Sciences

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Published Papers (3 papers)

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Research

21 pages, 4743 KiB  
Article
A Crude 1-DNJ Extract from Home Made Bombyx Batryticatus Inhibits Diabetic Cardiomyopathy-Associated Fibrosis in db/db Mice and Reduces Protein N-Glycosylation Levels
by Qing Zhao, Tian Zhu Jia, Qi Chen Cao, Fang Tian and Wan Tao Ying
Int. J. Mol. Sci. 2018, 19(6), 1699; https://doi.org/10.3390/ijms19061699 - 7 Jun 2018
Cited by 18 | Viewed by 6004
Abstract
The traditional Chinese drug Bombyx Batryticatus (BB), which is also named the white stiff silkworm, has been widely used in Chinese clinics for thousands of years. It is famous for its antispasmodic and blood circulation-promoting effects. Cardiomyocyte hypertrophy, interstitial cell hyperplasia, and myocardial [...] Read more.
The traditional Chinese drug Bombyx Batryticatus (BB), which is also named the white stiff silkworm, has been widely used in Chinese clinics for thousands of years. It is famous for its antispasmodic and blood circulation-promoting effects. Cardiomyocyte hypertrophy, interstitial cell hyperplasia, and myocardial fibrosis are closely related to the N-glycosylation of key proteins. To examine the alterations of N-glycosylation that occur in diabetic myocardium during the early stage of the disease, and to clarify the therapeutic effect of 1-Deoxynojirimycin (1-DNJ) extracted from BB, we used the db/db (diabetic) mouse model and an approach based on hydrophilic chromatography solid-phase extraction integrated with an liquid Chromatograph Mass Spectrometer (LC-MS) identification strategy to perform a site-specific N-glycosylation analysis of left ventricular cardiomyocyte proteins. Advanced glycation end products (AGEs), hydroxyproline, connective tissue growth factor (CTGF), and other serum biochemical indicators were measured with enzyme-linked immunosorbent assays (ELISA). In addition, the α-1,6-fucosylation of N-glycans was profiled with lens culinaris agglutinin (LCA) lectin blots and fluorescein isothiocyanate (FITC)-labelled lectin affinity histochemistry. The results indicated that 1-DNJ administration obviously downregulated myocardium protein N-glycosylation in db/db mice. The expression levels of serum indicators and fibrosis-related cytokines were reduced significantly by 1-DNJ in a dose-dependent manner. The glycan α-1,6-fucosylation level of the db/db mouse myocardium was elevated, and the intervention effect of 1-DNJ administration on N-glycan α-1,6-fucosylation was significant. To verify this result, the well-known transforming growth factor-β (TGF-β)/Smad2/3 pathway was selected, and core α-1,6-fucosylated TGF-β receptor II (TGFR-βII) was analysed semi-quantitatively with western blotting. The result supported the conclusions obtained from LCA lectin affinity histochemistry and lectin blot analysis. The expression level of α-1,6-fucosyltransferase (FUT8) mRNA was also detected, and the results showed that 1-DNJ administration did not cause obvious inhibitory effects on FUT8 expression. Therefore, the mechanism of 1-DNJ for relieving diabetic cardiomyopathy (DCM)-associated fibrosis can be concluded as the inhibition of N-acetylglucosamine (N-GlcNAc) formation and the reduction of substrate concentration. Full article
(This article belongs to the Special Issue Translational Chemistry: From a Single Molecule to Biological Research)
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11 pages, 912 KiB  
Communication
Comparison of Three Extraction Approaches for the Isolation of Neurotransmitters from Rat Brain Samples
by Natalia Miękus, Ilona Olędzka, Darya Harshkova, Ivan Liakh, Alina Plenis, Piotr Kowalski and Tomasz Bączek
Int. J. Mol. Sci. 2018, 19(6), 1560; https://doi.org/10.3390/ijms19061560 - 24 May 2018
Cited by 8 | Viewed by 4847
Abstract
The determination of neurotransmitters (NTs) as relevant potential biomarkers in the study of various central nervous system (CNS) pathologies has been demonstrated. Knowing that NTs-related diseases mostly occupy individual regions of the nervous system, as observed, for instance, in neurodegenerative diseases (Alzheimer’s and [...] Read more.
The determination of neurotransmitters (NTs) as relevant potential biomarkers in the study of various central nervous system (CNS) pathologies has been demonstrated. Knowing that NTs-related diseases mostly occupy individual regions of the nervous system, as observed, for instance, in neurodegenerative diseases (Alzheimer’s and Parkinson’s Diseases), the analysis of brain slices is preferred to whole-brain analysis. In this report, we present sample preparation approaches, such as solid-phase extraction, solid-phase microextraction, and dispersive liquid–liquid microextraction, and discuss the pitfalls and advantages of each extraction method. The ionic liquid (1-ethyl-3-methylimidazolium tetrafluoroborate)-assisted solid-phase microextraction (IL-SPME) is found to be, in our research, the relevant step towards the simultaneous determination of six NTs, namely, dopamine (DA), adrenaline (A), noradrenaline (NA), serotonin (5-HT), l-tryptophan (l-Trp), l-tyrosine (l-Tyr) in rat brain samples. The development of a novel bioanalytical technique for the evaluation of biomarkers in the context of green chemistry might be accelerated just with the use of IL, and this approach can be considered an advantageous strategy. Full article
(This article belongs to the Special Issue Translational Chemistry: From a Single Molecule to Biological Research)
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24 pages, 6090 KiB  
Article
Preliminary Structure-Activity Relationship (SAR) of a Novel Series of Pyrazole SKF-96365 Analogues as Potential Store-Operated Calcium Entry (SOCE) Inhibitors
by Camille D. Dago, Paul Le Maux, Thierry Roisnel, Christophe Brigaudeau, Yves-Alain Bekro, Olivier Mignen and Jean-Pierre Bazureau
Int. J. Mol. Sci. 2018, 19(3), 856; https://doi.org/10.3390/ijms19030856 - 14 Mar 2018
Cited by 12 | Viewed by 3909
Abstract
From a series of (1R, 1S)-1[β-(phenylalkoxy)-(phenetyl)]-1H-pyrazolium hydrochloride as new analogues of SKF-96365, one has an interesting effect for endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) (IC50 25 μM) on the PLP-B [...] Read more.
From a series of (1R, 1S)-1[β-(phenylalkoxy)-(phenetyl)]-1H-pyrazolium hydrochloride as new analogues of SKF-96365, one has an interesting effect for endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) (IC50 25 μM) on the PLP-B lymphocyte cell line. A successful resolution of (±) 1-phenyl-2-(1H-pyrazol-1-yl)ethan-1-ol has been developed by using the method of “half-concentration” in the presence of (+)-(1S)- or (−)-(1R)-CSA. Full article
(This article belongs to the Special Issue Translational Chemistry: From a Single Molecule to Biological Research)
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