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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gastrointestinal Microbes: Implications for Health and Disease
edited by Suqin Hang
submission deadline 30 Aug 2025 | Viewed by 7 | Submission Open
Keywords: animal; gut; microbiota; gut hormone; nutrients
(This special issue belongs to the Section Molecular Microbiology)
Teleost in Biomedical Research submission deadline 31 Aug 2025 | 2 articles | Viewed by 5904 | Submission Open
Keywords: fish; teleost; experimental model; translational research; biomedicine; comparative studies
(This special issue belongs to the Section Molecular Biology)
Therapeutic Targets and Approaches to Manage Inflammation: Disappointing Past, Current Efforts and Faint Hopes
edited by Natasha Irrera
submission deadline 31 Aug 2025 | 2 articles | Viewed by 2225 | Submission Open
Keywords: inflammation; inflammatory pathways; resolution of inflammation; inflammasome; molecular pathways; anti-inflammatory response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Cancer Stem Cells
edited by
submission deadline 31 Aug 2025 | Viewed by 47 | Submission Open
Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma
(This special issue belongs to the Section Molecular Oncology)
Molecular Research and Applications of Nanomaterials
edited by
submission deadline 31 Aug 2025 | Viewed by 17 | Submission Open
Keywords: molecular research; application; functionality of nanomaterials; catalysis; environmental science
(This special issue belongs to the Section Molecular Nanoscience)
Emerging Insights into Lymphoid Organ Development, Regulation and Therapeutic Potential
edited by Hélia Neves
submission deadline 31 Aug 2025 | Viewed by 14 | Submission Open
Keywords: thymus; immune; signaling; molecular; pathways; epigenetics; organoids; bioengineering; regeneration; clinical application
(This special issue belongs to the Section Molecular Biology)
Cutting Edge Advances in Antitumor Properties of Natural Products submission deadline 31 Aug 2025 | Viewed by 11 | Submission Open
Keywords: natural product; cancer; cell signaling; cell death and differentiation; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Computational, Structural and Spectroscopic Studies of Macromolecules
edited by Sanja Dolanski Babić
submission deadline 10 Sep 2025 | 2 articles | Viewed by 2706 | Submission Open
Keywords: macromolecules; structure DNA; effects on DNA; protein; carbohydrate; lipids; spectroscopic methods; FTIR; NMR; UV; CD; numerical methods
(This special issue belongs to the Section Macromolecules)
Advances in Molecular Research of Facial Adipose Compartments
edited by Marius Valeriu Hînganu
submission deadline 15 Sep 2025 | Viewed by 5 | Submission Open
Keywords: facial fat; facial adipose tissue; molecular markers of facial fat; hormonal environmental; metabolic disorders; facial deformities; single-cell RNA sequencing; CRISPR-Cas9 gene editing
(This special issue belongs to the Section Molecular Biology)
Recent Approaches for Wound Treatment—2nd Edition submission deadline 20 Sep 2025 | 7 articles | Viewed by 17295 | Submission Open
(This special issue belongs to the Section Molecular Pharmacology)
Biomaterials for Dental and Orthopedic Applications
edited by and
submission deadline 20 Sep 2025 | 8 articles | Viewed by 12092 | Submission Open
(This special issue belongs to the Section Materials Science)
Mitochondrial Dysfunction: A Metabolic, Cardiovascular, Neurodegenerative and Neuromuscular Issue: 2nd Edition
edited by , and Claudia Nesti
submission deadline 20 Sep 2025 | 3 articles | Viewed by 6849 | Submission Open
Keywords: bioenergetics; mitochondrial disorders; biomarkers; OxPhos complexes; mitochondrial DNA; aging; neurodegenerative diseases; cardiovascular diseases; metabolic diseases; therapies to counteract mitochondrial dysfunction TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Noncovalent Interactions and Applications in Materials and Catalysis
edited by Snežana D. Zarić
submission deadline 20 Sep 2025 | 4 articles | Viewed by 3992 | Submission Open
Keywords: noncovalent interactions; materials; catalysis; crystal structures; quantum chemistry calculations; hydrogen bonds; stacking interactions; spectroscopy
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Role of Natural Compounds in Human Health and Disease
edited by Jaewon Shim and
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3164 | Submission Open
Keywords: natural compound; therapeutic applications; action mechanisms of natural compounds; traditional medicine
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Research of Metallic Nanoparticles
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3090 | Submission Open
Keywords: metallic nanoparticles (MNPs); biosensors; synthesis methods; molecular spectroscopy characteristic; molecular medicine; molecular biology
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms and Therapies for Metabolic-Associated Fatty Liver Diseases
edited by Yi-Ming Arthur Chen
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2538 | Submission Open
Keywords: metabolic-associated fatty liver disease; MAFLD; metabolic dysfunction-associated steatohepatitis; MASH; molecular mechanism; genetic polymorphism; individualized medicine; prevention; new drug development; health supplements; diagnosis; epidemiology; lifestyle
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Flow Cytometry: Applications and Challenges
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2534 | Submission Open
Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies
(This special issue belongs to the Section Molecular Biology)
Biofunctional Coatings for Medical Applications submission deadline 20 Sep 2025 | 3 articles | Viewed by 2360 | Submission Open
Keywords: biofunctional coatings; thin film deposition techniques; surface engineering; tissue engineering; materials’ doping and co-doping; medical applications
(This special issue belongs to the Section Materials Science)
Adapter CAR T Cells: From the Idea to the Clinic submission deadline 20 Sep 2025 | 1 articles | Viewed by 2049 | Submission Open
Keywords: CAR T cell therapy; chimeric antigen receptor; bispecific antibody; target module; autoimmune diseases; solid tumors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Dimensional Design, Synthesis Modification and Application of Sustainable Polymer Materials
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1606 | Submission Open
Keywords: sustainable polymeric materials; 3D printing; sustainability; environmental impact; molecular modifications
(This special issue belongs to the Section Materials Science)
Compounds with Added Value from Marine Algae for Biomedical Applications submission deadline 20 Sep 2025 | 1 articles | Viewed by 1402 | Submission Open
Keywords: algae bioactive compounds; algal biotechnology for biomedical purposes; algal-derived biomedical materials; algal-based drug delivery systems; alginate; carrageenan; fucoidan; marine polysaccharides; marine peptides; marine polyphenols; marine antioxidants; marine bioactive compounds; marine glycosaminoglycans; marine biopolymers and biomaterials; marine lipids; marine-derived pharmaceuticals; marine-derived cosmeceuticals; marine-derived nutraceuticals; marine algae added-value products; marine drugs discovery; marine natural products; marine-derived anti-inflammatory agents; marine antimicrobial compounds; marine-derived anticancer agents; marine neuroprotective compounds; marine-derived anti-aging compounds; marine-based regenerative medicine; phycobiliproteins; seaweed-based tissue engineering materials; seaweed-derived bioactive molecules; seaweed extracts; seaweed-based wound healing materials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Fungal Pathogen-Host Interactions
edited by Patricia Albuquerque
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1189 | Submission Open
Keywords: medical mycology; host– microbe interactions; macrophages; dendritic cells; neutrophils
(This special issue belongs to the Section Molecular Microbiology)
Bilirubin: Health Challenges and Opportunities
edited by
submission deadline 20 Sep 2025 | Viewed by 587 | Submission Open
Keywords: bilirubin; biomedical science; neurobiology; Parkinson’ s disease; brain neuroprotection
(This special issue belongs to the Section Molecular Biology)
Genetic and Epigenetic Insights into Extracellular Vesicles submission deadline 20 Sep 2025 | Viewed by 581 | Submission Open
Keywords: exosomes; extracellular vesicles; cell– cell communication; endocrinology
(This special issue belongs to the Section Biochemistry)
Cell Biology and Biochemistry Regulation Mediated by Natural Compounds
edited by
submission deadline 20 Sep 2025 | Viewed by 561 | Submission Open
Keywords: cellular targets; natural compounds; nutraceuticals; health-promoting effects; enzymatic activity; cell-based assays; in vivo; nanoencapsulation; delivery of natural compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Current Trends in MOF (Metal–Organic Framework) and Metal X-ides Development, 2nd Edition
edited by Siwei Li
submission deadline 20 Sep 2025 | Viewed by 508 | Submission Open
Keywords: MOF; metal carbide; metal sulfide; metal phosphide; catalysis; biomedicine; electromagnetic absorption; energy conversion and storage
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms and Pathophysiology of Cystic Fibrosis
edited by and George M. Solomon
submission deadline 20 Sep 2025 | Viewed by 446 | Submission Open
Keywords: cystic fibrosis; aging; CF airway disease; CF complications; CF molecular pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Therapeutic Advances in Pancreatic Cancer
edited by
submission deadline 20 Sep 2025 | Viewed by 346 | Submission Open
Keywords: pancreatic cancer; therapeutic advancements; tumor microenvironment; personalized medicine; biomarkers; liquid biopsy; targeted therapies; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Chemicals Impacts on the Reproductive System
edited by Giovanna Liguori and
submission deadline 20 Sep 2025 | Viewed by 322 | Submission Open
Keywords: endocrine disruptors; environmental pollution; female reproduction; male reproduction
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
New Biomarkers in Pancreatic Diseases
edited by and
submission deadline 20 Sep 2025 | Viewed by 226 | Submission Open
Keywords: pancreatic disease; pancreatic cancer; pancreatitis; biomarker; RNA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Multifunctional Nanocomposites for Bioapplications submission deadline 20 Sep 2025 | Viewed by 201 | Submission Open
Keywords: nanocomposites; biomedical applications; molecular characteristics; metabolic pathways; biomarkers; external stimuli
(This special issue belongs to the Section Molecular Nanoscience)
Molecular and Genomics Advances in Behaviours
edited by
submission deadline 20 Sep 2025 | Viewed by 196 | Submission Open
Keywords: unhealthy and healthy behaviors; smoking; sleeping; eating; alcoholism; gambling; aggression; addictive behaviors; physical activity; mental disorders
(This special issue belongs to the Section Molecular Biology)
Antitumor Activity of Natural Products submission deadline 25 Sep 2025 | Viewed by 67 | Submission Open
Keywords: natural compounds and extracts with antitumor activity; studies on molecular mechanisms; signal transduction modulation in tumor cells; immunomodulating activity; mitosis inhibition; cell differentiation; cell death induction (apoptosis/autophagy)
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Unveiling Molecular Mysteries of Brain Barriers
edited by Ana Catarina Duarte
submission deadline 25 Sep 2025 | Viewed by 31 | Submission Open
Keywords: blood– brain barrier; blood– cerebrospinal fluid barrier; arachnoid barrier; transport mechanisms; drug delivery; drug metabolism; ATP-binding cassete (ABC) transporters
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Epigenetic Mechanisms in Cognition
edited by Sabrina Venditti
submission deadline 25 Sep 2025 | Viewed by 31 | Submission Open
Keywords: epigenetics; DNA methylation; histone modifications; noncoding RNAs; cognition; learning and memory; neuroplasticity; neurodegeneration; ASD; training
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Magnetic Materials: Synthesis, and Applications
edited by Artur Chrobak
submission deadline 25 Sep 2025 | Viewed by 28 | Submission Open
Keywords: magnetic materials; properties; synthesis; applications
(This special issue belongs to the Section Materials Science)
Plant Breeding: High-Yield and Quality, Stress-Resistant Trait Genetic Improvement and Application
edited by Juwu Gong
submission deadline 29 Sep 2025 | Viewed by 21 | Submission Open
Keywords: plant breeding; crop genetic improvement; gene editing; stress resistance; crop quality; crop yield; gene resource utilization
(This special issue belongs to the Section Molecular Plant Sciences)
Current Research for Heart Disease Biology and Therapeutics (Third Edition)
edited by Claudia Kusmic
submission deadline 29 Sep 2025 | Viewed by 13 | Submission Open
Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Serum Amyloid A (SAA) Family: (Patho)Physiological Functions in (Non)Mammalian Systems submission deadline 30 Sep 2025 | 4 articles | Viewed by 6535 | Submission Open
Keywords: Serum Amyloid A in (Non)Mammalian systems; phylogenetic overview of different SAA isoforms; expression of SAA1-4 on mRNA and protein level; comparison of SAA with other acute-phase reactants; role of SAA during normal development and inflammation; role of SAA in cancer and other malignancies; potential role of SAA as a suitable biomarker during disease progression
(This special issue belongs to the Section Biochemistry)
Molecular Targeted Therapy for Gliomas
edited by Ka-Kit Leung
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1771 | Submission Open
Keywords: targeted therapy; glioma and glioblastoma; treatment strategies; identification of biomarkers; diagnosis; prognosis; molecular pathology; signalling pathways; molecular imaging; tumour microenvironment
(This special issue belongs to the Section Molecular Oncology)
Optical Materials: Molecular Advances of Their Synthesis, Properties and Medical Applications submission deadline 30 Sep 2025 | Viewed by 395 | Submission Open
Keywords: optical materials; luminescence; luminescence thermometry; laser materials; phosphors; biocompatible optical materials; optical imaging; fluorescent nanoparticles; rare-earth ion-doped nanomaterials; hard and soft tissue engineering; laser imaging systems
(This special issue belongs to the Section Materials Science)
Molecular Mechanism of VCP/p97 in Health and Diseases
edited by
submission deadline 30 Sep 2025 | Viewed by 279 | Submission Open
Keywords: AAA ATPase; VCP/p97/cdc48/TER ATPase; AAA ATPase; protein unfolding; protein degradation; protein quality control; ERAD; mitochondria-associated degradation; lysosome degradation; ribosome-associated degradation; membrane fusion and trafficking; ubiquitin; TDP43; inclusion body myopathy (IBM); paget disease (PD); frontotemporal dementia (FD); MSP1; amyotrophic lateral sclerosis (ALS); charcot-marie-tooth disease 2Y; Parkinson’ s disease; intellectual development disabilities (IDDs); lysosomal diseases; tauopathies
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into the Precision Medicine on Neoplastic Diseases: Challenges, Perspectives and Opportunities
edited by
submission deadline 30 Sep 2025 | Viewed by 272 | Submission Open
Keywords: cancer; molecular biology; precision medicine; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Computational Studies of Ionic Liquids and Their Analogues
edited by and Elisabete Ferreira
submission deadline 30 Sep 2025 | Viewed by 152 | Submission Open
Keywords: ionic liquids; deep eutectic solvents; molecular dynamics; density functional theory; COSMO-RC; machine learning; ab initio
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
MicroRNAs as Biomarkers and Therapeutic Targets in Human Diseases
edited by Elena V. Bichenkova
submission deadline 30 Sep 2025 | Viewed by 14 | Submission Open
Keywords: microRNA biomarkers; diagnostic profiling; expression patterns; miRNA therapeutics; antimiRs; miRNA mimics; hybridisation; sequence-specificity; miRNA knockdown
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetics of Human Disease: Emphasis on X-linked Diseases and Clinical Practice
edited by Antonella La Russa
submission deadline 15 Oct 2025 | Viewed by 210 | Submission Open
Keywords: rare diseases; X-linked disease; X chromosome inactivation (XCI); mosaicism; epigenome; undiagnosed rare diseases; phenotype– genotype correlations; biomarkers; personalized medicine; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Players in the Research of Oxidative Stress and Cancer submission deadline 20 Oct 2025 | 7 articles | Viewed by 21899 | Submission Open
Keywords: cancer; oxidative stress; biomarkes; redox signaling pathway; therapy resistance
(This special issue belongs to the Section Biochemistry)
Plant-Sourced Functional and Bioactive Compounds—Nature’s Blueprint for Improving Human Well-Being submission deadline 20 Oct 2025 | 3 articles | Viewed by 7948 | Submission Open
Keywords: plants; antioxidants; phytochemicals; phyto-nutrition; natural products; health enhancing
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Applicability of Graphene-Based Materials in the Pharmaceutical, Biological and Biomedical Sectors
edited by and Pogacean Florina
submission deadline 20 Oct 2025 | 5 articles | Viewed by 7330 | Submission Open
Keywords: graphene; graphene-based composites; graphene-based sensors; biomedical applications; tissue engineering; drug delivery
(This special issue belongs to the Section Molecular Nanoscience)
New Molecular Insights into Antimicrobial Photo-Treatments
edited by Pietro Delcanale
submission deadline 20 Oct 2025 | 2 articles | Viewed by 5791 | Submission Open
Keywords: photodynamic inactivation; photo-thermal therapy; photosensitization; antimicrobials; reactive oxygen species; photo-treatments; antibiotic resistance; singlet oxygen; antivirals
(This special issue belongs to the Section Molecular Microbiology)
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