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Metabolic Syndrome and Its Burden on Global Health
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Metabolic Syndrome and Its Burden on Global Health

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 754

Special Issue Editors

Dr. Umberto Goglia

E-Mail Website
Guest Editor
Endocrinology and Diabetology Unit, ASLCN1, 12100 Cuneo, Italy
Interests: endocrine; diabetes; metabolic diseases; cardiovascular disease
Dr. Luca Monge

E-Mail Website
Guest Editor
AMD-Italian Association of Clinical Diabetologists, 00192 Rome, Italy
Interests: endocrine; diabetes and metabolic diseases; diabetic foot
Prof. Dr. Elena Succurro

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
Interests: prediabetes; type 2 diabetes; myocardial insulin resistance; cardiovascular organ damage; sex differences in predia-betes; type 2 diabetes and cardiovascular disease; mechanism of action of SGLT2i; gestational diabetes
Special Issues, Collections and Topics in MDPI journals
Dr. Livia Pisciotta

E-Mail Website
Guest Editor
1. Dietetics and Clinical Nutrition Unit, IRCCS Policlinic Hospital San Martino, 16132 Genoa, Italy
2. Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy
Interests: clinical nutrition; clinical lipidology; genetics of dyslipidemias
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Salvatore De Rosa

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy
Interests: cardiovascular disease; biomarkers; interventional cardiology; atherothrombosis; atherosclerosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic syndrome, previously known as “syndrome X” or “insulin resistance syndrome”, is a widespread and complex condition characterized by an aggregation of metabolic dysregulations influenced by both genetic and environmental factors. This condition manifests in the context of insulin resistance and chronic low-grade inflammation. The prevalence of metabolic syndrome is increasing globally, particularly among certain populations such as women, young adults, and specific ethnic groups, highlighting underlying health disparities.
The clinical disorders included in metabolic syndrome share symptoms and signs that affect various tissues and organs within a highly complex and interplaying hormonal and molecular network.  Energy balance and nutrient utilization are critical for the development of specific diseases in both healthy individuals and those affected by metabolic syndrome.
This syndrome significantly contributes to highly prevalent conditions such as obesity, with the accumulation of visceral and epicardial adipose tissue, type 2 diabetes mellitus, and metabolic dysfunction-associated steatotic liver disease (MASLD). Additionally, it notably increases the risk of cardiovascular disease (particularly diabetic cardiomyopathy, vascular and valvular calcifications, and heart failure) and chronic kidney disease, profoundly affecting morbidity and mortality.
Together, these conditions represent a significant clinical and economic burden, posing a pandemic-scale challenge for the coming decades, particularly concerning treatment and prevention.

Dr. Umberto Goglia
Dr. Luca Monge
Prof. Dr. Elena Succurro
Dr. Livia Pisciotta
Prof. Dr. Salvatore De Rosa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • insulin resistance
  • chronic low-grade inflammation
  • gut microbiota
  • energy balance
  • obesity
  • hyperlipidemia
  • metabolic dysfunction-associated steatotic liver (MASLD)
  • type 2 diabetes mellitus
  • heart failure
  • diabetic cardiomyopathy
  • cardio-nephro-metabolic syndrome
  • metabolic syndrome sex differences
  • metabolic syndrome and health inequity
  • metabolic syndrome health-economic burden

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Published Papers (1 paper)

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Research

15 pages, 2336 KiB  
Article
A Longitudinal Assessment of Metabolic Syndrome
by Dilbar Aidarbekova, Karlygash Sadykova, Yerbolat Saruarov, Nursultan Nurdinov, Mira Zhunissova, Kumissay Babayeva, Dinara Nemetova, Ainur Turmanbayeva, Aigerim Bekenova, Gulnaz Nuskabayeva and Antonio Sarria-Santamera
J. Clin. Med. 2025, 14(3), 747; https://doi.org/10.3390/jcm14030747 - 24 Jan 2025
Viewed by 309
Abstract
Background/Objectives: Metabolic syndrome (MetS) is a combination of conditions including central obesity, high blood pressure, high glucose levels, and abnormal triglycerides and cholesterol, which together increase the chances of heart disease, diabetes, and even death. The rates of MetS are different around [...] Read more.
Background/Objectives: Metabolic syndrome (MetS) is a combination of conditions including central obesity, high blood pressure, high glucose levels, and abnormal triglycerides and cholesterol, which together increase the chances of heart disease, diabetes, and even death. The rates of MetS are different around the world, with 20–30% in Europe and 21.8–23.9% in Kazakhstan. Because MetS changes over time, it is important to study the dynamics of their components to improve prevention and treatments. This work aims to obtain the incidence of MetS and to evaluate the specific components associated with the emergence of new MetS cases in this population. Methods: This is a longitudinal study with a 10-year follow-up in Turkestan city between 2012 and 2024. Information was collected through physical exams, blood tests, and anthropometric measurements. Logistic regression and ROC curve analysis were used to find which factors increase the incidence of MetS. Results: Among 434 participants analyzed (78.8% women, and mean age 40.87, 66% < 2 MetS components, 20% had MetS blood pressure, and 65.9% had MetS waist circumference), the incidence of MetS at follow-up was 40%. The key risk factors for newly diagnosed MetS included elevated blood pressure and increased waist circumference. Multivariate analyses highlighted these components as the strongest predictors of MetS, with significant associations observed for participants with two or more MetS components at baseline. Conclusions: Elevated blood pressure and central obesity were identified as pivotal contributors to MetS progression. Given the rising prevalence of Mets and its implications, these results show the need to start treatment and check these risks early to prevent serious health problems. Full article
(This article belongs to the Special Issue Metabolic Syndrome and Its Burden on Global Health)
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