Sensors and Biosensors: Fabrication, Properties and Biomedical Application

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 1684

Special Issue Editors


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Guest Editor
College of Materials, Xiamen University, Xiamen 361005, China
Interests: biomaterials; drug delivery; nanomedicine; biodiagnosis; bioimaging
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Biomedical Engineering, Hainan University, Haikou 570228, China
Interests: flexible electronics; biosensing; bioprinting; organoids; in vitro neuronal networks
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A biosensor is defined by its biological or bioinspired receptor unit with unique specificities toward corresponding analytes, such as target metabolites, hormones, viruses, bacteria, antigens, pharmaceuticals, toxins, as well as entire cells in various sensing media, ranging from buffers to more complex environments, such as sweat, saliva, urine, and blood. Biosensing, in general, also includes the recording of electrophysiological signals of the human body, including ECG, EMG, EEG, ECoG, motion signals, etc., which is also defined as bioelectronics. The important parameters of biosensing are the detection specificity and sensitivity. In order to increase sensitivities and to lower detection limits down to even individual molecules, many new techniques are developed over recent decades, such as various kinds of nanomaterials, biomimetic designs, flexible electronics, lab-on-a chip, as well as microfabrication and microfluidics, called microelectromechanical systems (MEMS). Biosensing has been intensively applied in biomedical fields, such as medical diagnostics, the early screening of diseases, point-of-care testing, and healthcare monitoring.

This Special Issue aims to collect recent advances in fabrication, properties, and biomedical application of biosensors and bioelectronics, as well as relevant prospects in terms of opportunities and challenges. High-quality research articles, short communications, and reviews are welcome.

Prof. Dr. Lei Ren
Prof. Dr. Dong Wang
Guest Editors

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Keywords

  • biosensing
  • biosensors
  • bioelectronics
  • wearable device
  • e-textile
  • diagnostics
  • theranostics
  • healthcare monitoring

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Published Papers (1 paper)

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Research

14 pages, 3108 KiB  
Article
pH-Activated Dissolvable Polymeric Coatings to Reduce Biofouling on Electrochemical Sensors
by Ahmet Uçar, Eva González-Fernández, Matteo Staderini, Alan F. Murray, Andrew R. Mount and Mark Bradley
J. Funct. Biomater. 2023, 14(6), 329; https://doi.org/10.3390/jfb14060329 - 20 Jun 2023
Cited by 1 | Viewed by 1345
Abstract
Implantable electrochemical sensors that enable the real-time detection of significant biomarkers offer huge potential for the enhancement and personalisation of therapies; however, biofouling is a key challenge encountered by any implantable system. This is particularly an issue immediately after implantation, when the foreign [...] Read more.
Implantable electrochemical sensors that enable the real-time detection of significant biomarkers offer huge potential for the enhancement and personalisation of therapies; however, biofouling is a key challenge encountered by any implantable system. This is particularly an issue immediately after implantation, when the foreign body response and associated biofouling processes are at their most active in passivating a foreign object. Here, we present the development of a sensor protection and activation strategy against biofouling, based on coatings consisting of a pH-triggered, dissolvable polymer, that covered a functionalised electrode surface. We demonstrate that reproducible delayed sensor activation can be achieved, and that the length of this delay can be controlled by the optimisation of coating thickness, homogeneity and density through tuning of the coating method and temperature. Comparative evaluation of the polymer-coated and uncoated probe-modified electrodes in biological media revealed significant improvements in their anti-biofouling characteristics, demonstrating that this offers a promising approach to the design of enhanced sensing devices. Full article
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