Stimuli-Responsive Materials and Their Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2008

Special Issue Editor

School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China
Interests: novel drug delivery systems; pharmaceutical nanotechnology, and multifunctional nanomaterials for controlled drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Stimuli-responsive materials have been widely studied in biomedical applications. They are able to sense one or more environmental “triggers” (e.g., pH, redox, temperature, light, reactive oxygen species, enzyme, glucose, ionic strength, and electric and magnetic fields) to subsequently change their intrinsic physical or chemical properties. Therefore, these stimuli-responsive materials have attracted major attention as smart materials in drug delivery, tissue engineering, biosensing, bioseparation, immobilized biocatalysis, diagnostics, and many other systems.

This Special Issue will host papers related to recent developments in the field of biomedical applications of stimuli-responsive materials. Topics will include but not be limited to microenvironment-responsive materials, field-responsive materials, biologically responsive materials, organic materials, inorganic materials, drug delivery systems, tissue engineering, imaging, and diagnostics. In this regard, I would like to invite authors to contribute research articles and review papers on these topics.

Dr. Lipeng Qiu
Guest Editor

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Keywords

  • stimuli-responsive materials
  • drug delivery
  • nanomaterials
  • responsive polymers
  • tumor treatment
  • biomedical engineering

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Published Papers (1 paper)

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Research

15 pages, 22293 KiB  
Article
GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic Therapy
by Weijun Chen, Meiyang Yang, Jie Li, Zhilan Chen, Lefei Hu, Jiannan Zhang, Liangyu Cai, Lipeng Qiu and Jinghua Chen
J. Funct. Biomater. 2023, 14(9), 436; https://doi.org/10.3390/jfb14090436 - 23 Aug 2023
Cited by 3 | Viewed by 1544
Abstract
Chemotherapy (CT) plays an important role in the antitumor process, but the unsatisfactory therapeutic efficacy and the obvious toxic side effects of CT seriously restrict its application. To overcome the limitations of CT, the strategy of chemotherapy enhanced by chemodynamic therapy (CDT) and [...] Read more.
Chemotherapy (CT) plays an important role in the antitumor process, but the unsatisfactory therapeutic efficacy and the obvious toxic side effects of CT seriously restrict its application. To overcome the limitations of CT, the strategy of chemotherapy enhanced by chemodynamic therapy (CDT) and photothermal therapy (PTT) has been considered a promising approach to improve the anticancer effect. Herein, a novel GSH-activatable Cu2+-Quercetin network (QC) was synthesized via a convenient strategy to load Au nanoparticles (NPs) and DOX, named QCDA, for the synergistic therapy of CT/CDT/PTT. The results showed that QCDA exhibited GSH-sensitive degradation and “cargos” release in cancer cells, and then PTT and CDT caused by Au NPs and Cu+ significantly enhanced the CT effect of DOX and Quercetin on anticancer. More importantly, the PTT and depleted GSH accelerated the Fenton-like ionization process resulting in facilitating the CDT efficiency. Collectively, the multi-mode synergistic strategy of CT/CDT/PTT, which showed an excellent therapeutic effect, maybe a potential therapeutic pathway for anticancer. Full article
(This article belongs to the Special Issue Stimuli-Responsive Materials and Their Biomedical Applications)
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