Theranostic Nanocompounds: Synthesis and Applications in Personalized Medicine

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Cancer Therapies".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 2124

Special Issue Editors

1. Interdisciplinary Research Institute in Bio-Nano-Sciences, Babes-Bolyai University, 400271 Cluj-Napoca, Romania
2. National Institute for Research and Development of Isotopic and Molecular Technologies, 400293 Cluj-Napoca, Romania
Interests: nanoparticles; nanocompounds; drug delivery; theranostics; nanomedicine; nanotoxicology
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Guest Editor
Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania
Interests: nanomaterials; polymers; biomarkers; disease prevention; preclinical and clinical trials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A growing research domain that paves the way towards personalized medicine for the benefit of patients has spawned through the recent emergence of nanotechnology. Theranostics, as its name suggests, is a combination of ‘therapy’ and ‘diagnostics’ to optimize the efficacy and safety of therapeutic regimes. Derived from this hybrid field, new opportunities have arisen for the development of novel drug delivery systems and nanoplatforms capable of simultaneously detecting, monitoring, and treating specific diseases at targeted sites. Research efforts have been made in the design of multifunctional theranostic compounds such as polymeric, carbon, lipid, and protein drug delivery vehicles and imaging contrast agents. Nanotheranostic systems based on metallic or magnetic nanoparticles can also be used for both imaging and thermal therapeutic applications. In this Special Issue, we intend to explore recent advances in the field of theranostics, from the presentation of the fundamental components of theranostic compounds to the necessary steps and imposed regulations for their implementation in clinics.

Dr. Sanda Boca
Dr. Gianina Dodi
Guest Editors

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Keywords

  • theranostics
  • nanoparticles
  • nanocompounds
  • drug delivery
  • nanomedicine
  • nanotoxicology
  • biodistribution
  • bioengineering
  • imaging

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Published Papers (1 paper)

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Research

16 pages, 2343 KiB  
Article
Optimization of Tyrosine Kinase Inhibitor-Loaded Gold Nanoparticles for Stimuli-Triggered Antileukemic Drug Release
by Andra-Sorina Tatar, Timea Nagy-Simon, Adrian Bogdan Tigu, Ciprian Tomuleasa and Sanda Boca
J. Funct. Biomater. 2023, 14(8), 399; https://doi.org/10.3390/jfb14080399 - 27 Jul 2023
Cited by 1 | Viewed by 1647
Abstract
Tyrosine kinase inhibitor (TKI) therapy is gaining attraction in advanced cancer therapeutics due to the ubiquity of kinases in cell survival and differentiation. Great progress was made in the past years in identifying tyrosine kinases that can function as valuable molecular targets and [...] Read more.
Tyrosine kinase inhibitor (TKI) therapy is gaining attraction in advanced cancer therapeutics due to the ubiquity of kinases in cell survival and differentiation. Great progress was made in the past years in identifying tyrosine kinases that can function as valuable molecular targets and for the entrapment of their corresponding inhibitors in delivery compounds for triggered release. Herein we present a class of drug-delivery nanocompounds based on TKI Midostaurin-loaded gold nanoparticles that have the potential to be used as theranostic agents for the targeting of the FMS-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia. We optimized the nanocompounds’ formulation with loading efficiency in the 84–94% range and studied the drug release behavior in the presence of stimuli-responsive polymers. The therapeutic activity of MDS-loaded particles, superior to that of the free drug, was confirmed with toxicities depending on specific dosage ranges. No effect was observed on FLT3-negative cells or for the unloaded particles. Beyond druggability, we can track this type of nanocarrier inside biological structures as demonstrated via dark field microscopy. These properties might contribute to the facilitation of personalized drug dosage administration, critical for attaining a maximal therapeutic effect. Full article
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