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Calcium Phosphate Composites: From Synthesis to Biomedical Application
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Calcium Phosphate Composites: From Synthesis to Biomedical Application

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 2324

Special Issue Editor

Dr. Maja Dutour Sikirić

E-Mail Website
Guest Editor
Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia
Interests: crystallization of biologically relevant minerals; bioimplants for hard tissue regeneration; surfactants selfassembly; dynamic light scattering characterization of (bio)nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The need for advanced biomaterials produced in an environmentally friendly and economical way is constantly growing. In this sense, special attention is paid to multifunctional materials that can not only perform their basic task, i.e., tissue replacement or regeneration, but also serve as a carrier system for bioactive components.

Among different biomaterials, calcium phosphate (CaPs) composites occupy a special place in hard tissue regeneration. Although the main motivation for the development of CaPs composites was originally to improve the mechanical properties of CaPs, the biological activity of some of the components used allowed the development of multifunctional biomaterials. Moreover, the wide variety of (nano)materials that can be used in the fabrication of CaPs-based composites allows us to tailor of the properties of the composites to specific applications.

This Special Issue aims to bring together recent advances in the design, synthesis, and characterization of calcium phosphate-based composites for biomedical applications. In this way, we hope to deepen the fundamental understanding of these materials and contribute to the rationalization of their design and synthesis.

I am pleased to invite you to submit a manuscript for publication in this Special Issue. Full papers, communications, and reviews are welcome.

Dr. Maja Dutour Sikirić
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • calcium phosphates
  • hydroxyapatite
  • composites
  • nanostructired materials
  • characterization
  • tissue regeneration
  • biomedical application
  • multifunctional biomaterials
  • synthesis

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Published Papers (1 paper)

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Research

15 pages, 3575 KiB  
Article
Safety and Osteointegration of Titanium Screws Coated with a Fibroblast Growth Factor-2–Calcium Phosphate Composite Layer in Non-Human Primates: A Pilot Study
by Yukei Matsumoto, Hirotaka Mutsuzaki, Yuki Hara, Katsuya Nagashima, Eriko Okano, Yohei Yanagisawa, Hiroshi Noguchi, Tadashi Sankai and Masashi Yamazaki
J. Funct. Biomater. 2023, 14(5), 261; https://doi.org/10.3390/jfb14050261 - 8 May 2023
Cited by 3 | Viewed by 1778
Abstract
Spinal instrumentation surgery for older patients with osteoporosis is increasing. Implant loosening may occur due to inappropriate fixation in osteoporotic bone. Developing implants that achieve stable surgical results, even in osteoporotic bone, can reduce re-operation, lower medical costs, and maintain the physical status [...] Read more.
Spinal instrumentation surgery for older patients with osteoporosis is increasing. Implant loosening may occur due to inappropriate fixation in osteoporotic bone. Developing implants that achieve stable surgical results, even in osteoporotic bone, can reduce re-operation, lower medical costs, and maintain the physical status of older patients. Fibroblast growth factor-2 (FGF-2) promotes bone formation; thus, coating pedicle screws with an FGF-2–calcium phosphate (FGF-CP) composite layer is hypothesized to enhance osteointegration in spinal implants. We designed a long-term implantation pilot study that estimated the safety and bone-forming efficacy of pedicle screws coated with an FGF-CP composite layer in cynomolgus monkeys. Titanium alloy screws, either uncoated (controls) or aseptically coated with an FGF-CP composite layer, were implanted in the vertebral bodies of six female adult cynomolgus monkeys (three monkeys per group) for 85 days. Physiological, histological, and radiographic investigations were performed. There were no serious adverse events, and no radiolucent areas were observed around the screws in either group. The bone apposition rate in the intraosseous region was significantly higher in the FGF-CP group than in the controls. Moreover, as analyzed by Weibull plots, the bone formation rate of the FGF-CP group exhibited a significantly higher regression line slope than the control group. These results demonstrated that there was significantly less risk of impaired osteointegration in the FGF-CP group. Our pilot study suggests that FGF-CP-coated implants could promote osteointegration, be safe, and reduce the probability of screw loosening. Full article
(This article belongs to the Special Issue Calcium Phosphate Composites: From Synthesis to Biomedical Application)
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